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    SMART HEADPHONE DEVICE PERSONALIZATION SYSTEM AND METHOD FOR USING THE SAME
    1.
    发明申请
    SMART HEADPHONE DEVICE PERSONALIZATION SYSTEM AND METHOD FOR USING THE SAME 审中-公开

    公开(公告)号：US20180332391A1

    公开(公告)日：2018-11-15

    申请号：US15971259

    申请日：2018-05-04

    申请人： PING ZHAO ,  EI-EU CHANG

    发明人： PING ZHAO ,  EI-EU CHANG

    IPC分类号： H04R3/04 ,  H03G5/16 ,  H03G5/00 ,  H04R1/10

    CPC分类号： H04R5/033 ,  A61B5/123 ,  H04M1/24 ,  H04R5/04 ,  H04R29/00 ,  H04R2460/01 ,  H04R2460/07

    摘要： Disclosed are a smart headphone device personalization system and a method for using the system. A user downloads a headphone personalization application program unit from the server device for installation in a mobile device. The Mobile device and the smart headphone device are paired. The user enters corresponding data through the register module of the mobile device. The user wears the smart headphone device to allow a hearing inspection module of the mobile device to inspect hearing capabilities of left and right ears of the user and generate an inspection result. The automatic compensation unit of the smart headphone device may automatically carry out compensation according to the inspection result. Then, the manual compensation module of the mobile device further carries out compensation. Finally, the user adjusts the sound effect mode by using the preference setting module of the mobile device to complete personalization of the smart headphone device.

    Weighted request rate limiting for resources
    3.
    发明授权
    Weighted request rate limiting for resources 有权
    资源加权请求率限制

    公开(公告)号：US09058210B2

    公开(公告)日：2015-06-16

    申请号：US12948599

    申请日：2010-11-17

    申请人： Bhaven Avalani ,  Abhinav Kumar ,  Ronald Francis Murphy ,  Ping Zhao

    发明人： Bhaven Avalani ,  Abhinav Kumar ,  Ronald Francis Murphy ,  Ping Zhao

    IPC分类号： G06F15/173 ,  G06F9/50 ,  H04L12/54 ,  G06F17/30 ,  H04L29/08 ,  H04L29/06

    CPC分类号： H04L47/70 ,  G06F9/5011 ,  G06F9/505 ,  G06F17/30657 ,  G06F17/30864 ,  G06F2209/504 ,  H04L63/10 ,  H04L67/22 ,  Y02D10/22

    摘要： Methods and systems to automatically respond to consider the weight of a request when responding to requests associated with resources are described. In one embodiment, an interface module may be configured to receive a request associated with consumer identifier and a resource. A calculator module may be configured to determine a weight of the request and a usage module configured to calculate, using a processor, a usage level associated with the consumer identifier, the usage level based on a usage history associated with the consumer identifier. An enforcer module may also be configured to respond to the request based on the usage level and the weight of the request. In one embodiment, the usage module may also be configured to update the usage level associated with the consumer identifier based on the weight of the request.

    摘要翻译： 描述在响应与资源相关联的请求时自动响应的方法和系统来考虑请求的权重。 在一个实施例中，接口模块可以被配置为接收与消费者标识符和资源相关联的请求。 计算器模块可以被配置为确定请求的权重，并且使用模块被配置为基于与消费者标识符相关联的使用历史来使用处理器来计算与消费者标识符相关联的使用水平的使用水平。 执行者模块还可以被配置为基于请求的使用级别和权重来响应请求。 在一个实施例中，使用模块还可以被配置为基于请求的权重来更新与消费者标识符相关联的使用水平。

    Aminothiazolones as estrogen related receptor-alpha modulators
    6.
    发明授权
    Aminothiazolones as estrogen related receptor-alpha modulators 有权
    氨基噻唑酮作为雌激素相关受体α调节剂

    公开(公告)号：US08426604B2

    公开(公告)日：2013-04-23

    申请号：US13028266

    申请日：2011-02-16

    申请人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    发明人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    IPC分类号： C07D417/14 ,  C07D211/32 ,  C07D415/00 ,  C07D419/00 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/495 ,  A61K31/44 ,  A61K31/535 ,  A61K31/501 ,  A61K31/445 ,  A61K31/00

    CPC分类号： C07D417/06 ,  C07D417/14

    摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

    摘要翻译： 本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期 关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失， 软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性 骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨 骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

    Substituted aminothiazolone indazoles as estrogen related receptor-alpha modulators
    7.
    发明授权
    Substituted aminothiazolone indazoles as estrogen related receptor-alpha modulators 有权
    取代的氨基噻唑酮吲唑作为雌激素相关受体α调节剂

    公开(公告)号：US08399681B2

    公开(公告)日：2013-03-19

    申请号：US13566214

    申请日：2012-08-03

    申请人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    发明人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    IPC分类号： C07D277/14 ,  C07D211/32 ,  C07D513/00 ,  C07D413/14 ,  C07D223/02 ,  C07D243/08 ,  C07D295/04 ,  A61K31/397 ,  A61K31/55 ,  A61K31/535 ,  A61K31/50 ,  A61K31/497 ,  A61K31/445

    CPC分类号： C07D417/14 ,  C07D417/06 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D498/08

    摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

    摘要翻译： 本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期 关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失， 软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性 骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨 骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

    SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS
    9.
    发明申请
    SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS 有权
    作为雌激素相关受体 - 阿尔法调节剂的替代氨苄西泮

    公开(公告)号：US20120302544A1

    公开(公告)日：2012-11-29

    申请号：US13566214

    申请日：2012-08-03

    申请人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    发明人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    IPC分类号： A61K31/454 ,  A61K31/5377 ,  A61K31/427 ,  A61P19/00 ,  A61P19/04 ,  A61P19/06 ,  A61P19/10 ,  A61P35/04 ,  A61P35/00 ,  A61P19/08 ,  A61P19/02 ,  A61P1/02 ,  A61P11/00 ,  A61P11/08 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P3/10 ,  A61K31/4985 ,  A61K31/496

    CPC分类号： C07D417/14 ,  C07D417/06 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D498/08

    摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

    摘要翻译： 本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期 关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失， 软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性 骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨 骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

    Substituted aminothiazolone indazoles as estrogen related receptor-alpha modulators
    10.
    发明授权
    Substituted aminothiazolone indazoles as estrogen related receptor-alpha modulators 有权
    取代的氨基噻唑酮吲唑作为雌激素相关受体α调节剂

    公开(公告)号：US08263781B2

    公开(公告)日：2012-09-11

    申请号：US12969984

    申请日：2010-12-16

    申请人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    发明人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    IPC分类号： C07D277/14 ,  C07D211/32 ,  C07D513/00 ,  C07D413/14 ,  C07D223/02 ,  C07D243/08 ,  C07D295/04 ,  A61K31/397 ,  A61K31/55 ,  A61K31/535 ,  A61K31/50 ,  A61K31/497 ,  A61K31/445 ,  A61K31/425

    CPC分类号： C07D417/14 ,  C07D417/06 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D498/08

    摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

    摘要翻译： 本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期 关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失， 软骨变性和与软骨形成相关的软骨变性），软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性呕吐，脂质障碍，代谢综合征 骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨 骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。