公开(公告)号：US08254939B2

公开(公告)日：2012-08-28

申请号：US12043105

申请日：2008-03-05

申请人： Qing Xia ,  Xingchen Lu ,  Jun Yuan

发明人： Qing Xia ,  Xingchen Lu ,  Jun Yuan

IPC分类号： H04W40/00 ,  H04W4/00 ,  H04M11/00 ,  H04L12/56 ,  H04J3/16

CPC分类号： H04L12/14 ,  H04L12/1428 ,  H04M15/00 ,  H04M15/41 ,  H04M15/53 ,  H04M15/62 ,  H04M15/63 ,  H04M15/8292 ,  H04M2215/0164 ,  H04M2215/0172 ,  H04M2215/204 ,  H04W4/24

摘要： System and method for combining call records for different protocols into a single combined call record during a call. An embodiment comprises correlating messages having multiple protocol formats, comprising correlating messages complying with a first protocol into a first call record using a first correlation key, correlating messages complying with a second protocol into a second call record using a second correlation key, detecting a key message complying with the first protocol, the key message having a fetch key parameter associated with messages complying with the second protocol, combining data from the second call record into the first call record to create a combined call record, and creating a pointer linking the second call record to the first call record.

摘要翻译： 在呼叫期间将用于不同协议的呼叫记录组合成单个组合呼叫记录的系统和方法。 实施例包括将具有多个协议格式的消息相关联，包括使用第一相关密钥将符合第一协议的消息与第一呼叫记录相关联，使用第二相关密钥将符合第二协议的消息与第二呼叫记录相关联，检测密钥 所述密钥消息具有与符合所述第二协议的消息相关联的获取密钥参数，将来自所述第二呼叫记录的数据组合到所述第一呼叫记录中以创建组合呼叫记录，以及创建指向所述第二协议 呼叫记录到第一个呼叫记录。

公开(公告)号：US09683019B2

公开(公告)日：2017-06-20

申请号：US14963391

申请日：2015-12-09

申请人： Frederic Zecri ,  Philipp Grosche ,  Kayo Yasoshima ,  Hongjuan Zhao ,  Jun Yuan ,  Aimee Richardson Usera ,  Changgang Lou ,  Aaron Kanter ,  Alexandra Marshall Bruce ,  Carla Guimaraes

发明人： Frederic Zecri ,  Philipp Grosche ,  Kayo Yasoshima ,  Hongjuan Zhao ,  Jun Yuan ,  Aimee Richardson Usera ,  Changgang Lou ,  Aaron Kanter ,  Alexandra Marshall Bruce ,  Carla Guimaraes

IPC分类号： A61K38/12 ,  C07K7/64 ,  C07K16/46 ,  A61K45/06 ,  C07K14/47 ,  A61K47/48 ,  C07K14/765

CPC分类号： C07K14/47 ,  A61K38/12 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/542 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6811 ,  C07K7/64 ,  C07K14/765 ,  C07K16/461 ,  C07K2319/30 ,  C07K2319/31

摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13  I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09340582B2

公开(公告)日：2016-05-17

申请号：US14336290

申请日：2014-07-21

申请人： Jun Yuan ,  Frederic Zecri ,  Philipp Grosche ,  Hongjuan Zhao ,  Eric Peters ,  Shari Lynn Caplan ,  Changgang Lou

发明人： Jun Yuan ,  Frederic Zecri ,  Philipp Grosche ,  Hongjuan Zhao ,  Eric Peters ,  Shari Lynn Caplan ,  Changgang Lou

IPC分类号： C07K14/47 ,  C07K7/08 ,  A61K47/48 ,  A61K45/06 ,  A61K38/10 ,  C07K16/00 ,  A61K39/395

CPC分类号： A61K38/10 ,  A61K38/00 ,  A61K45/06 ,  A61K47/542 ,  A61K47/643 ,  A61K47/68 ,  A61K47/6811 ,  C07K14/47 ,  C07K14/765 ,  C07K2319/30 ,  C07K2319/31

摘要： The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供包含式I'（SEQ ID NO：1）的合成多肽的生物缀合物或其酰胺，其酯或其盐，其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，X 8，X 9 ，X10，X11，X12和X13在本文中定义并且半衰期延长部分，其中肽和半衰期延长部分任选地经由连接体共价连接或融合。 多肽是APJ受体的激动剂。 本发明还涉及本发明的生物缀合物的制备方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，布鲁加达综合征，室性心动过速，动脉粥样硬化 ，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（ 包括晒伤）和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US09036570B2

公开(公告)日：2015-05-19

申请号：US13264936

申请日：2010-04-16

申请人： Sophie Vrzic ,  Mo-Han Fong ,  DongSheng Yu ,  Robert Novak ,  Jun Yuan

发明人： Sophie Vrzic ,  Mo-Han Fong ,  DongSheng Yu ,  Robert Novak ,  Jun Yuan

IPC分类号： H04W4/00 ,  H04W72/00 ,  H04W36/38 ,  H04W72/04 ,  H04J13/16

CPC分类号： H04W36/385 ,  H04J13/16 ,  H04L5/0007 ,  H04L5/0037 ,  H04L5/0092 ,  H04W72/042 ,  H04W72/0453

摘要： A method and system are provided to perform channelization in a wireless communication network, wherein the wireless communication network including at least one base station that is communicatively coupled to at least one mobile terminal. A bandwidth of the wireless communication network is divided into a plurality of zones at the base station. Resource blocks are provided at the base station to receive data symbols transmitted in the wireless communication network. A plurality of resource blocks are combined at the base station to form a physical basic channel unit which are allocated to one of the plurality of zones at the base station. A permutation is performed on the physical basic channel unit to form a logical basic channel unit. A channel is provided to communicatively couple the base station and the mobile terminal so that the mobile terminal may send an access grant message and a user identification to the base station to transmit data in the logical basic channel unit.

摘要翻译： 提供了一种在无线通信网络中执行信道化的方法和系统，其中所述无线通信网络包括通信地耦合到至少一个移动终端的至少一个基站。 无线通信网络的带宽在基站被分成多个区域。 在基站处提供资源块以接收在无线通信网络中发送的数据符号。 在基站处组合多个资源块，以形成分配给基站的多个区域之一的物理基本信道单元。 在物理基本信道单元上执行置换以形成逻辑基本信道单元。 提供了一种通信来通信地耦合基站和移动终端，使得移动终端可以向基站发送接入许可消息和用户标识以在逻辑基本信道单元中发送数据。

公开(公告)号：US20150031604A1

公开(公告)日：2015-01-29

申请号：US14336262

申请日：2014-07-21

申请人： Frederic ZECRI ,  Philipp GROSCHE ,  Kayo YASOSHIMA ,  Hongjuan ZHAO ,  Jun Yuan ,  Aimee Richardson USERA ,  Changgang LOU ,  Aaron KANTER ,  Alexandra Marshall BRUCE ,  Carla Giumaraes

发明人： Frederic ZECRI ,  Philipp GROSCHE ,  Kayo YASOSHIMA ,  Hongjuan ZHAO ,  Jun Yuan ,  Aimee Richardson USERA ,  Changgang LOU ,  Aaron KANTER ,  Alexandra Marshall BRUCE ,  Carla Giumaraes

IPC分类号： C07K7/64 ,  A61K38/12 ,  A61K45/06 ,  C07K16/46

CPC分类号： C07K14/47 ,  A61K38/12 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/542 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6811 ,  C07K7/64 ,  C07K14/765 ,  C07K16/461 ,  C07K2319/30 ,  C07K2319/31

摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13  I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式I（SEQ ID NO：1）的环状多肽：X1-R-X3-X4-LS-X7-X8-X9-X10-X11-X12-X13I或酰胺，酯或盐 或其生物缀合物，其中X1，X3，X4，X7，X8，X9，X10，X11，X12和X13在本文中定义。 多肽是APJ受体的激动剂。 本发明还涉及制备本发明多肽或其生物缀合物的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，心室 心动过速，动脉粥样硬化，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，潴留，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化， 烧伤（包括晒伤）和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US08671395B1

公开(公告)日：2014-03-11

申请号：US12879458

申请日：2010-09-10

申请人： Jun Yuan ,  Akok Jain ,  Manpreet Singh Reehal ,  Vinaya Kumar Singh

发明人： Jun Yuan ,  Akok Jain ,  Manpreet Singh Reehal ,  Vinaya Kumar Singh

IPC分类号： G06F9/44 ,  G06F9/455

CPC分类号： G06F17/5009 ,  G06F2217/06

摘要： The present disclosure relates to a method for avoiding deadends in a constrained simulation. The method may include analyzing a first deadend during a simulation and a first constraint of the simulation. The method may further include determining if the first constraint causes the first deadend. If the first constraint causes the first deadend, the method may also include defining a first lookahead constraint corresponding to the first constraint. The method may additionally include rerunning a first previous cycle in the simulation while adding the first lookahead constraint to the simulation.

摘要翻译： 本公开涉及一种用于在受限模拟中避免死角的方法。 该方法可以包括在模拟期间分析第一死区和模拟的第一约束。 所述方法还可以包括确定所述第一约束是否引起所述第一死锁。 如果第一约束导致第一个停止，则该方法还可以包括定义与第一约束相对应的第一前瞻约束。 该方法可以另外包括在模拟中重新运行第一先前循环，同时将第一前视约束添加到模拟中。

公开(公告)号：US08649468B2

公开(公告)日：2014-02-11

申请号：US13609245

申请日：2012-09-10

申请人： Rui Wang ,  Song Pan ,  Jian Cui ,  Jun Yuan ,  Yajun Hu

发明人： Rui Wang ,  Song Pan ,  Jian Cui ,  Jun Yuan ,  Yajun Hu

IPC分类号： H04L27/06

CPC分类号： H04B3/542

摘要： The present invention provides a micro-controller, a processing method and device for power line carrier signal reception, where the method includes: an analog mixer mixes received power line carrier signals, an analog filter filters the mixed power line carrier signals, an analog-to-digital converter converts the filtered signals, a digital mixer mixes converted signals, a digital filter filters the mixed signals and a digital demodulator demodulates the filtered signals to obtain base band data. The present invention also provides a corresponding device and a micro-controller including the device. The technical solution of the present invention can modulate the carrier signals of any frequency to a fixed frequency through two-stage frequency mixing, so that demodulation of power line carrier signals with any frequency is possible.

摘要翻译： 本发明提供了一种用于电力线载波信号接收的微控制器，处理方法和装置，其中所述方法包括：模拟混频器混合接收到的电力线载波信号，模拟滤波器对混合电力线载波信号进行滤波， 数字转换器转换滤波后的信号，数字混频器混合转换的信号，数字滤波器对混合信号进行滤波，并且数字解调器解调滤波后的信号以获得基带数据。 本发明还提供了包括该装置的相应装置和微控制器。 本发明的技术方案可以通过两级混频将任何频率的载波信号调制到固定频率，从而可以对具有任何频率的电力线载波信号进行解调。

公开(公告)号：US08633193B2

公开(公告)日：2014-01-21

申请号：US13014066

申请日：2011-01-26

申请人： Jun Yuan ,  Peter Hrnciar ,  Qin Guo ,  George D. Maynard

发明人： Jun Yuan ,  Peter Hrnciar ,  Qin Guo ,  George D. Maynard

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P37/00 ,  A61P37/06 ,  A61P11/06 ,  A61P17/06

CPC分类号： C07D471/04

摘要： Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: wherein R, R2, R5, E, Z1, Z3, Z4, and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds of the invention bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds, which are useful as probes for the localization of C5a receptors.

摘要翻译： 吡咯并 - 吡啶，吡咯并 - 嘧啶和相关的杂环化合物，其分子式如下：其中R，R 2，R 5，E，Z 1，Z 3，Z 4和Ar如本文所定义。 这些化合物是C5a受体的配体。 本发明优选的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物以高亲和力结合C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗各种炎性，心血管和免疫系统疾病中的用途。 此外，本发明提供了标记的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物，其可用作C5a受体定位的探针。

公开(公告)号：US08629022B2

公开(公告)日：2014-01-14

申请号：US13420730

申请日：2012-03-15

申请人： Dureseti Chidambarrao ,  Sunfei Fang ,  Yue Liang ,  Xiaojun Yu ,  Jun Yuan

发明人： Dureseti Chidambarrao ,  Sunfei Fang ,  Yue Liang ,  Xiaojun Yu ,  Jun Yuan

IPC分类号： H01L21/8234

CPC分类号： H01L27/092 ,  H01L21/823857 ,  H01L29/42368 ,  H01L29/513 ,  H01L29/517 ,  H01L29/66545 ,  H01L29/66583 ,  H01L29/78

摘要： A method of forming a semiconductor structure is provided. The method includes providing a structure including at least one dummy gate region located on a surface of a semiconductor substrate and a dielectric material layer located on sidewalls of the at least one dummy gate region. Next, a portion of the dummy gate region is removed exposing an underlying high k gate dielectric. A sloped threshold voltage adjusting material layer is then formed on an upper surface of the high k gate dielectric, and thereafter a gate conductor is formed atop the sloped threshold voltage adjusting material layer.

摘要翻译： 提供一种形成半导体结构的方法。 该方法包括提供包括位于半导体衬底的表面上的至少一个伪栅极区域和位于至少一个虚拟栅极区域的侧壁上的介电材料层的结构。 接下来，去除暴露下面的高k栅极电介质的虚拟栅极区域的一部分。 然后在高k栅极电介质的上表面上形成倾斜的阈值电压调节材料层，然后在倾斜的阈值电压调节材料层的顶部形成栅极导体。

公开(公告)号：US08527829B2

公开(公告)日：2013-09-03

申请号：US12988717

申请日：2009-04-21

申请人： Mo-Han Fong ,  Sophie Vrzic ,  Robert Novak ,  Jun Yuan ,  Dong-Sheng Yu

发明人： Mo-Han Fong ,  Sophie Vrzic ,  Robert Novak ,  Jun Yuan ,  Dong-Sheng Yu

IPC分类号： H04L1/18 ,  H04W4/00

CPC分类号： H04L1/1812 ,  H04L1/0003 ,  H04L1/0009 ,  H04L1/1816 ,  H04L1/1861 ,  H04L1/1887 ,  H04L1/1896 ,  H04L5/0055 ,  H04L5/14 ,  H04L27/2659 ,  H04L27/2666 ,  H04W28/04 ,  H04W72/005 ,  H04W72/042 ,  H04W72/044 ,  H04W72/0446 ,  H04W72/0453 ,  H04W72/1257 ,  H04W72/1268 ,  H04W88/04 ,  H04W88/06

摘要： Methods described herein are for wireless communication systems. One aspect of the invention is directed to a method for a HARQ process, in which the HARQ process includes a first transmission of an encoder packet and at least one retransmission. The method involves allocating a transmission resource for each respective transmission. The method involves transmitting control information from a base station to a mobile station for each respective transmission. The control information includes information to uniquely identify the HARQ process and an identification of one of a time resource, a frequency resource and a time and frequency resource that is allocated for the transmission. In some embodiments of the invention, specific control information is signalled from a base station to a mobile station to enable RAS-HARQ operation. In some embodiments of the invention, retransmission signaling in included as part of regular unicast signaling used for both first transmission and retransmissions. In some embodiments of the invention, a 3-state acknowledgement channel and associated error recovery operation enables the base station and mobile station to recover from control signaling error and reduce packet loss.