-
1.发明申请METHODS, NUCLEIC ACID CONSTRUCTS AND CELLS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开方法，用于治疗神经损伤性疾病的核酸结构和细胞公开(公告)号：US20130236964A1
公开(公告)日：2013-09-12
申请号：US13783607
申请日：2013-03-04
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Eldad MELAMED , Daniel Offen , Yosef Levy , Pnina Green
IPC: C12N5/0793
CPC classification number: C12N5/0619 , A01K67/027 , A01K2227/105 , A01K2267/0306 , A61K48/0058 , C12N15/635 , C12N15/85 , C12N2830/008 , C12N2830/205 , C12N2840/203
Abstract: A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.
Abstract translation: 提供治疗神经变性疾病的方法。 该方法通过向有需要的个体施用能够外源可调节的神经递质合成的细胞来实现，从而治疗神经变性疾病。
-
公开(公告)号：US20190201452A1
公开(公告)日：2019-07-04
申请号：US16353680
申请日：2019-03-14
Inventor： Daniel OFFEN , Michal DADON-NACHUM , Tali BEN-ZUR , Eldad MELAMED , David YAFFE
Abstract: An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
-
Patent Agency Ranking
公开(公告)号：US20140140968A1
公开(公告)日：2014-05-22
申请号：US14164286
申请日：2014-01-27
Inventor： Avinoam KADOURI , Avihay BAR-ILAN , Eldad MELAMED , Daniel OFFEN , Ofer SADAN , Merav BAHAT-STROMZA
IPC: C12N5/0775 , A61K38/18
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其使用方法。
-
公开(公告)号：US20160375098A1
公开(公告)日：2016-12-29
申请号：US15261959
申请日：2016-09-11
Inventor： Avinoam KADOURI , Avihay BAR-ILAN , Eldad MELAMED , Daniel OFFEN , Ofer SADAN , Merav BAHAT-STROMZA
IPC: A61K38/18
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
-
公开(公告)号：US20160279169A1
公开(公告)日：2016-09-29
申请号：US15180152
申请日：2016-06-13
Inventor： Daniel OFFEN , Michal DADON-NACHUM , Tali BEN-ZUR , Eldad MELAMED , David YAFFE
CPC classification number: A61K35/34 , A61K35/12 , A61K38/00 , A61K38/185 , A61K38/1866 , A61K38/30 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/13 , C12N2501/165 , C12N2510/00
Abstract: An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
-
公开(公告)号：US20180333458A1
公开(公告)日：2018-11-22
申请号：US16047129
申请日：2018-07-27
Inventor： Avinoam KADOURI , Avihay BAR-ILAN , Eldad MELAMED , Daniel OFFEN , Ofer SADAN , Merav BAHAT-STROMZA
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
-
公开(公告)号：US20180112185A1
公开(公告)日：2018-04-26
申请号：US15820521
申请日：2017-11-22
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Daniel OFFEN , Merav BAHAT-STROMZA , Eldad MELAMED
CPC classification number: A61K35/28 , A61K35/30 , C12N5/0622 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/40 , C12N2506/1353
Abstract: An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.
-
-
-
-
-
-
Search Results
7
records
(took 0.016 seconds)
