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    Method and system for desorption atmospheric pressure chemical ionization
    1.
    发明授权
    Method and system for desorption atmospheric pressure chemical ionization 有权

    公开(公告)号：US07544933B2

    公开(公告)日：2009-06-09

    申请号：US11653569

    申请日：2007-01-16

    申请人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltán Takáts ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    发明人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltán Takáts ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    IPC分类号： H01J49/00

    CPC分类号： H01J49/14

    摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

    Method and system for desorption atmospheric pressure chemical ionization
    2.
    发明授权
    Method and system for desorption atmospheric pressure chemical ionization 有权
    解吸大气压化学电离方法与系统

    公开(公告)号：US08076639B2

    公开(公告)日：2011-12-13

    申请号：US12481501

    申请日：2009-06-09

    申请人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltan Takáts ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    发明人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltan Takáts ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    IPC分类号： H01J49/26

    CPC分类号： H01J49/14

    摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

    摘要翻译： 解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。 具有锥形尖端的电极连接到高压电源。 锥形尖端从携带高速气体流的毛细管向外突出。 将溶剂的蒸气混合到围绕针的环形气流中。 通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。 从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。 溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它 能够研究分析物的仪器。

    Method and system for desorption atmospheric pressure chemical ionization
    3.
    发明申请
    Method and system for desorption atmospheric pressure chemical ionization 有权
    解吸大气压化学电离方法与系统

    公开(公告)号：US20090309020A1

    公开(公告)日：2009-12-17

    申请号：US12481501

    申请日：2009-06-09

    申请人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    发明人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    IPC分类号： H01J49/26 ,  H01J27/00 ,  H01J49/04

    CPC分类号： H01J49/14

    摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

    摘要翻译： 解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。 具有锥形尖端的电极连接到高压电源。 锥形尖端从携带高速气体流的毛细管向外突出。 将溶剂的蒸气混合到围绕针的环形气流中。 通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。 从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。 溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它 能够研究分析物的仪器。

    Electrosonic spray ionization method and device for the atmospheric ionization of molecules
    4.
    发明授权
    Electrosonic spray ionization method and device for the atmospheric ionization of molecules 有权
    电喷雾电离法和分子大气电离装置

    公开(公告)号：US07015466B2

    公开(公告)日：2006-03-21

    申请号：US10888869

    申请日：2004-07-09

    申请人： Zoltán Takáts ,  Robert G. Cooks

    发明人： Zoltán Takáts ,  Robert G. Cooks

    IPC分类号： B01D59/44 ,  H01J49/00

    CPC分类号： H01J49/167 ,  B05B5/03

    摘要： There is described a device and method for generating gaseous ions of a sample material such as molecules in solution at atmospheric pressure. The device includes a conduit for receiving a solution containing the material to be ionized and form a stream. A jet of gas at supersonic velocity is directed at the stream and interacts therewith. Droplets are formed and by the adiabatic expansion of the gas and vigorous evaporation of the solution gaseous ions are generated. In the method a stream of the sample solution is delivered from a conduit with an electric potential. A gas jet at supersonic velocity interacts with the delivered solution and through the action of adiabatic expansion of the gas and evaporation of the solution gaseous ions are formed.

    摘要翻译： 描述了用于产生样品材料的气体离子的装置和方法，例如在大气压下溶液中的分子。 该装置包括用于接收含有待离子化材料并形成流的溶液的导管。 超声速度的气体射流指向流并与其相互作用。 形成液滴，并且通过气体的绝热膨胀和溶液的剧烈蒸发产生气态离子。 在该方法中，样品溶液的流从具有电位的导管输送。 超音速的气体射流与输送的溶液相互作用，并且通过气体的绝热膨胀的作用和溶液的蒸发形成气态离子。

    Rectilinear ion trap and mass analyzer system and method
    7.
    发明授权
    Rectilinear ion trap and mass analyzer system and method 有权
    直线离子阱和质量分析仪系统及方法

    公开(公告)号：US06838666B2

    公开(公告)日：2005-01-04

    申请号：US10656667

    申请日：2003-09-04

    申请人： Zheng Ouyang ,  Robert G. Cooks

    发明人： Zheng Ouyang ,  Robert G. Cooks

    IPC分类号： G01N20060101 ,  H01J49/42

    CPC分类号： H01J49/422

    摘要： A new geometry ion trap and its use as a mass spectrometer is described. The ion traps can be combined linearly and in parallel to form systems for mass storage, analysis, fragmentation, separation, etc. of ions. The ion trap has a simple rectilinear geometry with a high trapping capacity. It can be operated to provide mass analysis in the mass-selective instability mode as well as the mass-selective stability mode. Arrays of multiple ion traps allow combinations of multiple gas-phase processes to be applied to the trapped ions to achieve high sensitivity, high selectivity and/or higher throughput in the analysis of ions.

    System and method for preparative mass spectrometry
    8.
    发明授权
    System and method for preparative mass spectrometry 有权
    制备质谱的系统和方法

    公开(公告)号：US07381373B2

    公开(公告)日：2008-06-03

    申请号：US11228826

    申请日：2005-09-16

    申请人： Thomas Blake ,  Zheng Ouyang ,  Robert G. Cooks

    发明人： Thomas Blake ,  Zheng Ouyang ,  Robert G. Cooks

    IPC分类号： B01L3/02 ,  B01L11/00 ,  B01D59/44 ,  H01J49/00 ,  G01N1/00 ,  G01N1/18 ,  G01N1/22

    CPC分类号： H01J49/02 ,  B82Y30/00 ,  H01J49/04 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25875

    摘要： A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion trap mass analyzer that accumulates the ions based on their mass to charge ratio. A surface is in cooperative relationship with the separator so that the separated molecules are soft landed onto the surface at different locations such that the collected molecules can be stored or further processed/analyzed.

    摘要翻译： 制备型质谱仪系统包括将混合物转化为混合物中分子的气相离子的离子发生器，以及根据其质荷比或迁移率分离离子的分离器。 分离器是一种线性离子阱质量分析仪，其基于其质荷比积聚离子。 表面与分离器具有协同关系，使得分离的分子在不同位置软着陆到表面上，使得收集的分子可以被储存或进一步加工/分析。

    System and method for the preparation of arrays of biological or other molecules
    9.
    发明授权
    System and method for the preparation of arrays of biological or other molecules 有权
    用于制备生物或其他分子阵列的系统和方法

    公开(公告)号：US07361311B2

    公开(公告)日：2008-04-22

    申请号：US10335007

    申请日：2002-12-31

    申请人： Robert G. Cooks ,  Zheng Ouyang

    发明人： Robert G. Cooks ,  Zheng Ouyang

    IPC分类号： B01L3/02 ,  B01L11/00 ,  B01D59/44 ,  H01J49/00 ,  G01N1/00 ,  G01N1/18 ,  G01N1/22

    CPC分类号： H01J49/04 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25875

    摘要： A method of separating species in a mixture of molecules, particles or atoms and collecting the separated species is described. The method comprises the steps of converting by ionization the species in the mixture to gas phase ions, separating the gas phase ions according to their mass charge ratio and/or mobility and collecting the separated ions. The system includes ionizing means such as electrospray to form the gas phase ions. The gas phase ions are separated by filtering, or in time or in space and soft-landed for collection such as on a surface.

    摘要翻译： 描述了在分子，颗粒或原子的混合物中分离物质并收集分离的物质的方法。 该方法包括以下步骤：通过电离将混合物中的物质转化为气相离子，根据其质荷比和/或迁移率分离气相离子并收集分离的离子。 该系统包括电离装置，例如电喷雾以形成气相离子。 气相离子通过过滤，或在时间上或在空间中分离，并且软着陆以用于收集，例如在表面上。