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15 条记录 (耗时 0.023 秒)

    Rectilinear ion trap and mass analyzer system and method
    3.
    发明授权
    Rectilinear ion trap and mass analyzer system and method 有权
    直线离子阱和质量分析仪系统及方法

    公开(公告)号：US06838666B2

    公开(公告)日：2005-01-04

    申请号：US10656667

    申请日：2003-09-04

    申请人： Zheng Ouyang ,  Robert G. Cooks

    发明人： Zheng Ouyang ,  Robert G. Cooks

    IPC分类号： G01N20060101 ,  H01J49/42

    CPC分类号： H01J49/422

    摘要： A new geometry ion trap and its use as a mass spectrometer is described. The ion traps can be combined linearly and in parallel to form systems for mass storage, analysis, fragmentation, separation, etc. of ions. The ion trap has a simple rectilinear geometry with a high trapping capacity. It can be operated to provide mass analysis in the mass-selective instability mode as well as the mass-selective stability mode. Arrays of multiple ion traps allow combinations of multiple gas-phase processes to be applied to the trapped ions to achieve high sensitivity, high selectivity and/or higher throughput in the analysis of ions.

    System and method for preparative mass spectrometry
    4.
    发明授权
    System and method for preparative mass spectrometry 有权
    制备质谱的系统和方法

    公开(公告)号：US07381373B2

    公开(公告)日：2008-06-03

    申请号：US11228826

    申请日：2005-09-16

    申请人： Thomas Blake ,  Zheng Ouyang ,  Robert G. Cooks

    发明人： Thomas Blake ,  Zheng Ouyang ,  Robert G. Cooks

    IPC分类号： B01L3/02 ,  B01L11/00 ,  B01D59/44 ,  H01J49/00 ,  G01N1/00 ,  G01N1/18 ,  G01N1/22

    CPC分类号： H01J49/02 ,  B82Y30/00 ,  H01J49/04 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25875

    摘要： A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion trap mass analyzer that accumulates the ions based on their mass to charge ratio. A surface is in cooperative relationship with the separator so that the separated molecules are soft landed onto the surface at different locations such that the collected molecules can be stored or further processed/analyzed.

    摘要翻译： 制备型质谱仪系统包括将混合物转化为混合物中分子的气相离子的离子发生器，以及根据其质荷比或迁移率分离离子的分离器。 分离器是一种线性离子阱质量分析仪，其基于其质荷比积聚离子。 表面与分离器具有协同关系，使得分离的分子在不同位置软着陆到表面上，使得收集的分子可以被储存或进一步加工/分析。

    System and method for the preparation of arrays of biological or other molecules
    5.
    发明授权
    System and method for the preparation of arrays of biological or other molecules 有权
    用于制备生物或其他分子阵列的系统和方法

    公开(公告)号：US07361311B2

    公开(公告)日：2008-04-22

    申请号：US10335007

    申请日：2002-12-31

    申请人： Robert G. Cooks ,  Zheng Ouyang

    发明人： Robert G. Cooks ,  Zheng Ouyang

    IPC分类号： B01L3/02 ,  B01L11/00 ,  B01D59/44 ,  H01J49/00 ,  G01N1/00 ,  G01N1/18 ,  G01N1/22

    CPC分类号： H01J49/04 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25875

    摘要： A method of separating species in a mixture of molecules, particles or atoms and collecting the separated species is described. The method comprises the steps of converting by ionization the species in the mixture to gas phase ions, separating the gas phase ions according to their mass charge ratio and/or mobility and collecting the separated ions. The system includes ionizing means such as electrospray to form the gas phase ions. The gas phase ions are separated by filtering, or in time or in space and soft-landed for collection such as on a surface.

    摘要翻译： 描述了在分子，颗粒或原子的混合物中分离物质并收集分离的物质的方法。 该方法包括以下步骤：通过电离将混合物中的物质转化为气相离子，根据其质荷比和/或迁移率分离气相离子并收集分离的离子。 该系统包括电离装置，例如电喷雾以形成气相离子。 气相离子通过过滤，或在时间上或在空间中分离，并且软着陆以用于收集，例如在表面上。

    Ion trap array mass spectrometer
    6.
    发明授权
    Ion trap array mass spectrometer 有权
    离子阱阵列质谱仪

    公开(公告)号：US06762406B2

    公开(公告)日：2004-07-13

    申请号：US09578673

    申请日：2000-05-25

    申请人： Robert G. Cooks ,  Ethan R. Badman ,  Zheng Ouyang ,  James M. Wells

    发明人： Robert G. Cooks ,  Ethan R. Badman ,  Zheng Ouyang ,  James M. Wells

    IPC分类号： H01J4942

    CPC分类号： H01J49/424 ,  H01J49/0013 ,  H01J49/009

    摘要： A mass spectrometer having an array of parallel and/or tandem ion traps. The ion traps are preferably formed by providing a body of conductive material with a plurality of holes forming ring electrodes and electrodes on opposite faces of said body, opposite the ends of said ring electrodes, to define with the ring electrodes a plurality of parallel ion traps.

    摘要翻译： 具有并联和/或串联离子阱的阵列的质谱仪。 离子阱优选通过在导电材料体上形成多个孔，所述多个孔在所述主体的与所述环形电极的端部相对的相对面上形成环形电极和电极，以与所述环形电极限定多个平行的离子阱 。

    Multiplexed mass spectrometer
    7.
    发明授权
    Multiplexed mass spectrometer 失效
    复用质谱仪

    公开(公告)号：US07157699B2

    公开(公告)日：2007-01-02

    申请号：US11092106

    申请日：2005-03-29

    申请人： Zheng Ouyang ,  Robert G. Cooks

    发明人： Zheng Ouyang ,  Robert G. Cooks

    IPC分类号： H01J49/26

    CPC分类号： H01J49/009 ,  H01J49/4205

    摘要： A multiplexed mass spectrometer system includes an array of mass analyzers and a data acquisition system. Each mass analyzer is associated with one or more data channels, and the data acquisition system selectively reduces the number of data channels through combinations of particular channels to define data acquisition modes for the molecular characterization of the samples. The selective reduction in channels can be achieved, for example by software manipulation of the acquired data or by combining the detected signals.

    摘要翻译： 复用质谱仪系统包括质量分析器阵列和数据采集系统。 每个质量分析器与一个或多个数据通道相关联，并且数据采集系统通过特定通道的组合选择性地减少数据通道的数量，以定义样品的分子表征的数据采集模式。 可以例如通过对获取的数据的软件操纵或通过组合检测到的信号来实现信道的选择性减少。

    Method and system for desorption atmospheric pressure chemical ionization
    9.
    发明申请
    Method and system for desorption atmospheric pressure chemical ionization 有权
    解吸大气压化学电离方法与系统

    公开(公告)号：US20090309020A1

    公开(公告)日：2009-12-17

    申请号：US12481501

    申请日：2009-06-09

    申请人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    发明人： Robert G. Cooks ,  Bogdan Gologan ,  Zoltan Takats ,  Justin M. Wiseman ,  Ismael Cotte-Rodriguez

    IPC分类号： H01J49/26 ,  H01J27/00 ,  H01J49/04

    CPC分类号： H01J49/14

    摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

    摘要翻译： 解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。 具有锥形尖端的电极连接到高压电源。 锥形尖端从携带高速气体流的毛细管向外突出。 将溶剂的蒸气混合到围绕针的环形气流中。 通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。 从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。 溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它 能够研究分析物的仪器。