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    Immobilized analytes
    1.
    发明授权
    Immobilized analytes 有权

    公开(公告)号：US11585811B2

    公开(公告)日：2023-02-21

    申请号：US16389066

    申请日：2019-04-19

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Uwe Kobold ,  Robert Lang ,  Andreas Leinenbach

    IPC: G01N33/53 ,  G01N33/566 ,  G01N33/68 ,  G01N33/543 ,  G01N33/573

    Abstract: A method for detecting an analyte involving a) contacting the analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within the analyte and/or within said capture agent in the capture complex and, thereby, releasing the analyte or a fragment thereof from the capture complex, and c) detecting at least one fragment of the analyte and, thereby, detecting the analyte is disclosed herein. A kit having i) a capture agent binding to an analyte; and ii) an agent cleaving at least one covalent bond within the analyte and/or within the capture agent; and to the use of a protease for releasing fragments of an analyte for detecting the analyte, wherein the analyte is bound to a solid surface via a capture agent is also disclosed herein.

    Copy protection for antibodies
    2.
    发明授权
    Copy protection for antibodies 有权

    公开(公告)号：US11491236B2

    公开(公告)日：2022-11-08

    申请号：US16852931

    申请日：2020-04-20

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Harmut Duefel ,  Uwe Kobold ,  Andreas Leinenbach

    IPC: A61K47/68 ,  G01N33/68 ,  G01N30/88

    Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.

    LC system and method with column backflushing
    5.
    发明授权
    LC system and method with column backflushing 有权

    公开(公告)号：US12123856B2

    公开(公告)日：2024-10-22

    申请号：US17659772

    申请日：2022-04-19

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Leinenbach ,  Aart Pieter van Doorn

    IPC: G01N30/02 ,  G01N30/36

    CPC classification number: G01N30/36 ,  G01N2030/027

    Abstract: A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.

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