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    Liquid chromatography—stream equivalence by single stream calibration
    1.
    发明授权
    Liquid chromatography—stream equivalence by single stream calibration 有权

    公开(公告)号：US11940427B2

    公开(公告)日：2024-03-26

    申请号：US17448063

    申请日：2021-09-20

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Benjamin Tiemann ,  Stefan Quint ,  Florian Schweinberger

    IPC: G01N30/72 ,  G01N30/02 ,  G01N30/88

    CPC classification number: G01N30/7266 ,  G01N30/88 ,  G01N2030/027

    Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current. The controller is further configured to carry out adjusting detection conditions of one or more of the multiple fluidic streams responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream to be detected by the mass spectrometer in the respective detection time window.

    TECHNIQUES FOR CHECKING STATE OF ANALYZERS
    5.
    发明申请
    TECHNIQUES FOR CHECKING STATE OF ANALYZERS 有权

    公开(公告)号：US20210116290A1

    公开(公告)日：2021-04-22

    申请号：US17066692

    申请日：2020-10-09

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Stefan Quint ,  Dieter Kempken

    IPC: G01F25/00 ,  G01F3/22

    Abstract: An automated method for detecting and/or monitoring a state of a degasser of an analyzer is provided, the degasser including a container configured to be evacuated. The method includes obtaining a time series of values indicative of pressures inside the container. The time series spans a period during which the container is evacuated or pressurized. The method further includes determining a liquid level state of the degasser which is determined by an amount of liquid present in the container based on the time series.

    Techniques for checking a validity of a mass axis calibration of a mass spectrometer of an analyzer system
    6.
    发明授权
    Techniques for checking a validity of a mass axis calibration of a mass spectrometer of an analyzer system 有权

    公开(公告)号：US12165859B2

    公开(公告)日：2024-12-10

    申请号：US17653539

    申请日：2022-03-04

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Stefan Quint ,  Florian Schweinberger

    IPC: H01J49/00

    Abstract: A method for checking a validity of a mass axis calibration of a mass spectrometer (MS) of an analyzer system, comprising obtaining a mass axis check sample spanning a predetermined m/z measurement range of the MS and automatically processing the sample, performing multiple full scan mode MS measurements of different types using the MS for the at least two mass axis points to obtain measurement data, wherein the different types include at least a first full scan MS measurement in a positive mode and a second measurement in a negative mode, or at least a first full scan measurement for a first mass filter and a second full scan measurement for a second mass filter; comparing the measurement data for each of the at least two mass axis points with respective reference data and determining if a condition is out of specification based on a result of the comparing steps.

    ANOMALY DETECTION OF GAS FLOW PARAMETERS IN MASS SPECTROMETRY
    8.
    发明申请
    ANOMALY DETECTION OF GAS FLOW PARAMETERS IN MASS SPECTROMETRY 有权

    公开(公告)号：US20220165557A1

    公开(公告)日：2022-05-26

    申请号：US17453683

    申请日：2021-11-05

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Robert Lang ,  Stefan Quint ,  Gabriele Punzmann

    IPC: H01J49/04 ,  H01J49/02 ,  H01J49/16 ,  G01N30/72

    Abstract: A mass spectrometry (MS) apparatus is provided. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer, and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.

    Method and device for multiple transition monitoring
    10.
    发明授权
    Method and device for multiple transition monitoring 有权

    公开(公告)号：US12255059B2

    公开(公告)日：2025-03-18

    申请号：US17805482

    申请日：2022-06-06

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Stefan Quint ,  Florian Schweinberger ,  Benjamin Tiemann

    IPC: H01J49/42

    Abstract: A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer is provided and comprises at least one voltage application step, wherein a direct current (DC) voltage and a radio frequency (AC) voltage are applied between two pairs of electrodes of at least one mass filter of the analyzer, wherein the AC voltage has an amplitude VAC and the DC voltage has an applicable voltage VDC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage, wherein an amplitude ΔVDC of the supplementary AC voltage is ≤ V DC , max 2 b + 1 , wherein VDC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board of the mass filter of the analyzer; and wherein at least one transition of the analyte is determined with at least one detector of the analyzer.

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