公开(公告)号：US11829357B2

公开(公告)日：2023-11-28

申请号：US17230698

申请日：2021-04-14

Applicant: SHIMADZU CORPORATION

Inventor： Satoru Watanabe

IPC: G06F16/00 ,  G06F16/245 ,  G06F16/248

CPC classification number: G06F16/245 ,  G06F16/248

Abstract: An analysis assistance device includes an estimator that estimates distribution of measurement quality index data using a plurality of analysis condition data to be provided to an analysis device and a plurality of measurement data obtained in the analysis device based on the plurality of analysis condition data, a calculator that calculates the measurement quality index data from the measurement data obtained from the analysis device, and a comparison outputter that compares and outputs for display the measurement quality index data estimated by the estimator and the measurement quality index data calculated by the calculator.

公开(公告)号：US11543392B2

公开(公告)日：2023-01-03

申请号：US17535774

申请日：2021-11-26

Applicant: SHIMADZU CORPORATION

Inventor： Taichi Tomono ,  Takayuki Iriki ,  Tomohiro Shagawa ,  Satoru Watanabe

IPC: G01N30/24 ,  G01N35/10 ,  G01N35/00 ,  G01N13/00 ,  G01N30/02

Abstract: An online HPLC dissolution test system includes a dissolution tester and a liquid chromatograph. An autosampler of the liquid chromatograph includes at least one flow vial, a sampling needle and an injection port. the flow vial is connected to the dissolution tester via a pipe and is for storing a sample solution supplied from the dissolution tester therein. The sampling needle is for collecting the sample solution by sucking from the flow vial. The injection port is for injecting the sample solution from the sampling needle into the analysis channel. The controller of the liquid chromatograph includes an immediate analyzing execution part configured to cause the autosampler to execute immediate analyzing operation for sucking the sample solution in the flow vial with the sampling needle and directly injecting the sample solution into the injection port when the sample solution is supplied from the dissolution tester to the flow vial.

公开(公告)号：US12085580B2

公开(公告)日：2024-09-10

申请号：US17277784

申请日：2018-09-27

Applicant: SHIMADZU CORPORATION

Inventor： Satoru Watanabe ,  Takeshi Yoshida ,  Fuyuki Okamoto ,  Yuma Okabe ,  Chihiro Yasui

IPC: G01N35/00 ,  G05B23/02 ,  G07C3/00

CPC classification number: G01N35/00712 ,  G07C3/00 ,  G05B23/02

Abstract: The automatic suitability determination system includes a check document storing part, a check document retrieving part, a determination test execution part, and a suitability determination part. The check document storing part stores suitability check documents. The check document retrieving part is configured to read out the suitability check document related to a determining target component of operational suitability from the check document storing part. The determination test execution part is configured to read information contained in the suitability check document read out by the check document retrieving part and to execute tests of suitability determination items specified in the suitability check document by making the determining target component of the operational suitability operate based on the information. The suitability determination part is configured to determine, based on results of the tests executed by the determination test execution part, suitability for the suitability determination items corresponding to the tests.

公开(公告)号：US12085543B2

公开(公告)日：2024-09-10

申请号：US17282764

申请日：2018-10-15

Applicant: SHIMADZU CORPORATION

Inventor： Satoru Watanabe

IPC: G01N30/02 ,  G01N30/32 ,  G01N30/82

CPC classification number: G01N30/32 ,  G01N30/82 ,  G01N2030/027 ,  G01N2030/324

Abstract: In a chromatograph, a mobile phase is supplied to any of a plurality of columns by a mobile phase supplier, and a sample is supplied to the column by a sample supplier. The sample that has passed through the column is detected by a detector. In a chromatographic control device, a flow rate of the mobile phase for the analysis with use of the column is registered by a flow rate registrar in association with column specifying information for specifying each column. The flow rate of the mobile phase registered in association with a selected column is acquired from registered content of the flow rate registrar. The chromatograph is controlled such that the analysis is performed by an analysis controller while the mobile phase is supplied to the selected column with use of the selected column and the flow rate of the mobile phase acquired by a flow rate acquirer.

公开(公告)号：US11913917B2

公开(公告)日：2024-02-27

申请号：US17125050

申请日：2020-12-17

Applicant: SHIMADZU CORPORATION

Inventor： Satoru Watanabe ,  Takashi Inoue

IPC: G01N30/24 ,  G01N30/36 ,  G01N30/02 ,  G01N30/38

CPC classification number: G01N30/24 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/385

Abstract: An autosampler includes a retention path for injecting a sample into a mobile phase that flows through an analysis path to a column, the retention path including a needle at a downstream end and holding the sample, an injection path including a port at an upstream end for injecting into the analysis path, the sample injected from the needle into the port, a low-pressure path having an upstream end connected to a pump, and a valve that can switch between a first state in which an upstream analysis path and a downstream analysis path are connected and a downstream end of the low-pressure path and an upstream end of the retention path are connected and a second state in which the upstream analysis path and the upstream end of the retention path are connected and the downstream end of the injection path and the downstream analysis path are connected.

公开(公告)号：US11486863B2

公开(公告)日：2022-11-01

申请号：US15734639

申请日：2018-12-19

Applicant: SHIMADZU CORPORATION

Inventor： Satoru Watanabe

IPC: G01N30/34 ,  G01N30/86 ,  G01N30/02

Abstract: An organic solvent containing liquid that does not include a component to be detected by a detector is used as a first solvent, and an organic solvent containing liquid that includes the component to be detected and is adjusted to have a concentration of an organic solvent that prevents a separation column from actually holding the component to be detected is used a second solvent. Further, a mobile phase is sent while a setting value of a concentration of the second solvent in the mobile phase is changed over time with the separation column provided on an analysis flow path, and an actual concentration of the second solvent in the mobile phase is found based on a detection signal of the detector when the mobile phase is sent at each setting value.

公开(公告)号：US11243191B2

公开(公告)日：2022-02-08

申请号：US16631508

申请日：2017-08-25

Applicant: SHIMADZU CORPORATION

Inventor： Taichi Tomono ,  Takayuki Iriki ,  Tomohiro Shagawa ,  Satoru Watanabe

IPC: G01N30/24 ,  G01N35/10 ,  G01N30/02 ,  G01N35/00

Abstract: An online HPLC dissolution test system includes a dissolution tester and a liquid chromatograph. An autosampler of the liquid chromatograph includes at least one flow vial, a sampling needle and an injection port. The flow vial is connected to the dissolution tester via a pipe and is for storing a sample solution supplied from the dissolution tester therein. The sampling needle is for collecting the sample solution by sucking from the flow vial. The injection port is for injecting the sample solution from the sampling needle into the analysis channel. The controller of the liquid chromatograph includes an immediate analyzing execution part configured to cause the autosampler to execute immediate analyzing operation for sucking the sample solution in the flow vial with the sampling needle and directly injecting the sample solution into the injection port when the sample solution is supplied from the dissolution tester to the flow vial.

公开(公告)号：US20220260536A1

公开(公告)日：2022-08-18

申请号：US17561196

申请日：2021-12-23

Applicant: SHIMADZU CORPORATION

Inventor： Satoru Watanabe

IPC: G01N30/86 ,  G01N30/32

Abstract: A liquid delivery pump (4), an analysis channel (2), an injector (6), a separation column (8), a detector (10), and a controller (12) are provided. Then, the controller (12) includes a setting value storage memory (14) that stores a setting value set by the user for the number of peaks in a chromatogram obtained during analysis started by injection of a sample into the mobile phase by the injector (6), a peak counter (18) configured to count the number of peaks in the chromatogram from start of the analysis, and an end trigger detector (20) configured to detect that the number of peaks from start of the analysis counted by the peak counter (18) reaches the setting value as an end trigger of the analysis being executed, and the controller (12) is configured to end the analysis being executed based on that the end trigger detector (20) detects the end trigger.