公开(公告)号：US12247961B2

公开(公告)日：2025-03-11

申请号：US17799741

申请日：2020-02-27

Applicant: SHIMADZU CORPORATION

Inventor： Shotaro Ando ,  Takashi Inoue ,  Tsutomu Watanabe ,  Hiroyuki Minato ,  Nobumitsu Fukushima

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/16 ,  G01N30/32 ,  G01N30/02

Abstract: A column accommodation device (1) includes a housing in which a column accommodation space (4) is provided, and a chip column (6) having a plate-shape and having an internal flow path (40) filled with a separation medium (41) is accommodated in the column accommodation space (4). An outer surface of the chip column (6) is provided with openings (42) respectively communicating with both ends of the internal flow path. Inside of the column accommodation space (4) is provided with a guide (18) for guiding the chip column (6) to a predetermined position. The column accommodation device (1) includes a seal device (32) for connecting and releasing pipes (44) to and from the openings (42) of the chip column (6), and a controller (46) configured to perform operation control of the seal device (32), and the controller (46) is configured to fluidly connect the pipes (44) with respect to the openings (42) of the chip column (6) when it is determined that the chip column (6) is arranged at the predetermined position.

公开(公告)号：US11821878B2

公开(公告)日：2023-11-21

申请号：US17285532

申请日：2018-10-23

Applicant: SHIMADZU CORPORATION

Inventor： Shotaro Ando ,  Takashi Inoue

IPC: G01N30/24 ,  G01N35/10 ,  G01N30/02

CPC classification number: G01N30/24 ,  G01N35/1004 ,  G01N35/1079 ,  G01N2030/027

Abstract: An autosampler includes an injection port for supplying a sample to an analysis device, a needle that collects the sample stored in a vial and injects the sample into the injection port, a cleaning unit that cleans the needle and a gas exhaust fan. The cleaning unit includes a cleaning container which stores a cleaning liquid and into which the needle is inserted, and a unit main body that has a space for storing the cleaning container and receiving the cleaning liquid overflowing from the cleaning container, and a unit gas exhaust passage for exhausting gas in the space outwardly of the cleaning unit. The unit main body has a unit opening through which the needle passes when accessing the cleaning container. The autosampler includes a boundary portion that separates a first region in which the injection port, the needle and the unit opening are arranged from a second region in which the gas exhaust fan is arranged, and a gas exhaust region which is connected to the unit gas exhaust passage via a gas exhaust opening provided at the boundary portion and into which gas exhausted from the space flows due to a negative pressure generated by the gas exhaust fan.

公开(公告)号：US11573212B2

公开(公告)日：2023-02-07

申请号：US16010966

申请日：2018-06-18

Applicant: Shimadzu Corporation

Inventor： Takashi Inoue

IPC: G01N30/46 ,  G01N30/34 ,  G01N30/02 ,  G01N30/20 ,  G01N30/30 ,  G01N30/32

Abstract: A first mixer mixes solvents therein. A second mixer has a capacity different from that of the first mixer, and mixes solvents therein. A first separation column is associated with the first mixer. A second separation column is associated with the second mixer. A first valve enables switchover between a first communication state in which the first mixer and the first separation column communicate with a detector, and a second communication state in which the second mixer and the second separation column communicate with the detector. Only by switching the first valve, it is possible to switch between the first communication state and the second communication state. The internal capacity of a flow channel in the first communication state differs from that in the second communication state. Therefore, it is easy to perform analysis with different internal capacities.

公开(公告)号：US11366133B2

公开(公告)日：2022-06-21

申请号：US16649099

申请日：2018-06-20

Applicant: Shimadzu Corporation

Inventor： Hiroyuki Minato ,  Takashi Inoue

IPC: G01N35/10 ,  B01L3/00 ,  G01N30/24 ,  G01N35/02

Abstract: The sample plate has a principal plane in which a plurality of wells is arranged. The sample plate has a plurality of through-holes each allowing a sampling needle to pass through in a region of the principal plane where the wells are not provided, and positions of the wells and positions of the through-holes are designed such that when two pieces of the sample plates are arranged up and down with a predetermined positional relationship in a state in which respective principal planes are arranged in parallel each other, the through-holes of the sample plate arranged on an upper side is arranged at positions directly above respective wells of the sample plate arranged on a lower side.

公开(公告)号：US12025631B2

公开(公告)日：2024-07-02

申请号：US17059859

申请日：2018-05-28

Applicant: SHIMADZU CORPORATION

Inventor： Takashi Inoue ,  Makoto Ogaito

IPC: G01N35/10 ,  B01D15/14 ,  B01F33/30 ,  B01F101/23 ,  G01N30/06 ,  G01N30/18 ,  G01N30/24

CPC classification number: G01N35/1095 ,  B01D15/14 ,  B01F33/30 ,  G01N30/06 ,  G01N30/18 ,  G01N30/24 ,  B01F2101/23 ,  G01N2030/067

Abstract: An automatic sample introduction device includes a needle, a sample loop, a mixer and a suction injection switch mechanism. The mixer is provided between the needle and the sample loop. The suction injection switch mechanism sequentially sucks first and second fluids into the sample loop through the needle and the mixer and injects the first and second fluids held in the sample loop into a predetermined injection port. A chromatograph includes the automatic sample introduction device having the above-mentioned configuration, an analysis column and a detector. The analysis column is connected to the injection port of the automatic sample introduction device, and the detector is connected to the analysis column.

公开(公告)号：US11913917B2

公开(公告)日：2024-02-27

申请号：US17125050

申请日：2020-12-17

Applicant: SHIMADZU CORPORATION

Inventor： Satoru Watanabe ,  Takashi Inoue

IPC: G01N30/24 ,  G01N30/36 ,  G01N30/02 ,  G01N30/38

CPC classification number: G01N30/24 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/385

Abstract: An autosampler includes a retention path for injecting a sample into a mobile phase that flows through an analysis path to a column, the retention path including a needle at a downstream end and holding the sample, an injection path including a port at an upstream end for injecting into the analysis path, the sample injected from the needle into the port, a low-pressure path having an upstream end connected to a pump, and a valve that can switch between a first state in which an upstream analysis path and a downstream analysis path are connected and a downstream end of the low-pressure path and an upstream end of the retention path are connected and a second state in which the upstream analysis path and the upstream end of the retention path are connected and the downstream end of the injection path and the downstream analysis path are connected.

公开(公告)号：US12105063B2

公开(公告)日：2024-10-01

申请号：US17295985

申请日：2018-12-12

Applicant: SHIMADZU CORPORATION

Inventor： Shotaro Ando ,  Takashi Inoue ,  Kenichi Yasunaga

IPC: G01N30/24 ,  G01N30/18 ,  G01N30/20

CPC classification number: G01N30/24 ,  G01N30/18 ,  G01N30/20 ,  G01N2030/185 ,  G01N2030/207

Abstract: The auto-sampler for chromatographs includes a needle for sampling configured to move while a tip end thereof faces vertically downward; a switching valve having a plurality of ports to which channels constituting a chromatograph are connected, the switching valve switching between port connecting conditions to switch between channel configurations; and an injection port including an opening at an upper surface thereof through which a tip end of the needle is inserted to make the needle fluidically communicate with a pipe connected to one port of the switching valve, and a needle seal configured to get into contact with an outer circumferential surface of the tip end portion to make the needle fluidically communicate with the pipe in a liquid-tight manner when the tip end of the needle is inserted through the opening.

公开(公告)号：US09851282B2

公开(公告)日：2017-12-26

申请号：US14759118

申请日：2013-03-29

Applicant: SHIMADZU CORPORATION

Inventor： Takashi Inoue

IPC: G01N1/42 ,  G01N30/24 ,  G01N30/16 ,  G01N30/06 ,  G01N30/18 ,  G01N35/00

CPC classification number: G01N1/42 ,  G01N30/06 ,  G01N30/16 ,  G01N30/18 ,  G01N30/24 ,  G01N2035/00445

Abstract: There are provided a sample cooling device capable of preventing air containing moisture from flowing into an accommodating chamber from outside the accommodating chamber, and of desirably dehumidifying air inside the accommodating chamber, and an autosampler provided with the same. Air is sent into an accommodating chamber 11 by a blower section 100 from outside the accommodating chamber 11 and the air is cooled by a dehumidifier section 13 to thereby cause dehumidified air to be supplied into the accommodating chamber 11. With the air sent into the accommodating chamber 11 by the blower section 100 from outside the accommodating chamber 11, the inside of the accommodating chamber 11 may be placed in a pressurized state. Since dehumidified air is supplied into the accommodating chamber 11 by air sent into the accommodating chamber 11 by the blower section 100 from outside the accommodating chamber 11 being cooled by the dehumidifier section 13, the humidity inside the accommodating chamber 11 may be prevented from rising due to the air that is sent from the blower section 100.

公开(公告)号：US12099072B2

公开(公告)日：2024-09-24

申请号：US17628029

申请日：2019-07-26

Applicant: SHIMADZU CORPORATION

Inventor： Mika Okada ,  Akari Takeda ,  Yamato Maeda ,  Yoshitake Yamamoto ,  Potsun Chiang ,  Yoshitaka Noda ,  Takashi Inoue

IPC: G01N35/10 ,  B01L3/02 ,  B25J9/16 ,  C12M1/00 ,  C12M1/26 ,  G01N35/00

CPC classification number: G01N35/1072 ,  B01L3/0237 ,  B25J9/1679 ,  B25J9/1682 ,  B25J9/1697 ,  C12M1/26 ,  C12M33/00 ,  C12M47/04 ,  G01N35/00732 ,  G01N35/1009 ,  G01N2035/0091

Abstract: A cell picking device includes a stage, a sucker, a driver, a work content receiver, a registrar and a device controller. A sample container is placed on the stage. The driver is provided to execute sample scraping work and sample sucking work using a pipette tip attached to the sucker. In a case in which selection of work contents of the driver is received by the work content receiver, a work procedure including the received work contents of the driver is registered by the registrar. The work of the driver is controlled by the device controller in accordance with the registered work procedure.

公开(公告)号：US11519886B2

公开(公告)日：2022-12-06

申请号：US17047022

申请日：2019-01-16

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke Yokoi ,  Takaaki Fujita ,  Takashi Inoue ,  Kenichi Yasunaga

IPC: G01N30/24 ,  G01N30/32 ,  G01N30/02

Abstract: An autosampler is switched selectively between an injecting mode where a sampling flow path is incorporated into an analysis flow path of a liquid chromatograph and a loading mode where the sampling flow path is not incorporated into the analysis flow path and injects a sample into the analysis flow path at a position farther upstream than a separation column by being switched to the injecting mode with the sample held in the sampling flow path, and includes a clog determiner configured to acquire a sending liquid pressure of a liquid sending pump that sends a mobile phase in the analysis flow path, obtain a variation value of the liquid sending pressure when the injecting mode and the loading mode are switched and determine presence or absence of a clog in a system incorporated into the analysis flow path in the injecting mode based on the obtained variation value.