公开(公告)号：US08383385B2

公开(公告)日：2013-02-26

申请号：US13009524

申请日：2011-01-19

申请人： Sarah Teter ,  Connie Ward ,  Joel Cherry ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

发明人： Sarah Teter ,  Connie Ward ,  Joel Cherry ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

IPC分类号： C12N9/42 ,  C12S3/00 ,  C12S3/02 ,  C12P19/14 ,  C11D3/386

CPC分类号： C12N9/2437 ,  C11D3/38645 ,  C12N9/2434 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021 ,  C12Y302/01091 ,  C12Y302/01176

摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。

公开(公告)号：US20050048619A1

公开(公告)日：2005-03-03

申请号：US10926223

申请日：2004-08-25

申请人： Sarah Teter ,  Joel Cherry ,  Connie Ward ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

发明人： Sarah Teter ,  Joel Cherry ,  Connie Ward ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

IPC分类号： C12N9/42 ,  C07H21/04 ,  C12N9/24 ,  C12P21/04

CPC分类号： C12N9/2437 ,  C11D3/38645 ,  C12N9/2434 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021 ,  C12Y302/01091 ,  C12Y302/01176 ,  Y02E50/16

摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。

公开(公告)号：US07932073B2

公开(公告)日：2011-04-26

申请号：US11891249

申请日：2007-08-08

申请人： Sarah Teter ,  Connie Ward ,  Joel Cherry ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

发明人： Sarah Teter ,  Connie Ward ,  Joel Cherry ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

IPC分类号： C12N9/42 ,  C12S3/00 ,  C11D3/00

CPC分类号： C12N9/2437 ,  C11D3/38645 ,  C12N9/2434 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021 ,  C12Y302/01091 ,  C12Y302/01176

摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。

公开(公告)号：US20110136167A1

公开(公告)日：2011-06-09

申请号：US13009524

申请日：2011-01-19

申请人： Sarah Teter ,  Joel Cherry ,  Connie Ward ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

发明人： Sarah Teter ,  Joel Cherry ,  Connie Ward ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

IPC分类号： C12P1/00 ,  C12N9/24 ,  C11D3/386

CPC分类号： C12N9/2437 ,  C11D3/38645 ,  C12N9/2434 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021 ,  C12Y302/01091 ,  C12Y302/01176

摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

公开(公告)号：US20080167214A1

公开(公告)日：2008-07-10

申请号：US11891249

申请日：2007-08-08

申请人： Sarah Teter ,  Joel Cherry ,  Connie Ward ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

发明人： Sarah Teter ,  Joel Cherry ,  Connie Ward ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

IPC分类号： C11D3/386 ,  C12N9/24 ,  C07H21/04 ,  C12N15/63 ,  C12N5/06 ,  C12P21/02 ,  B09C1/10

CPC分类号： C12N9/2437 ,  C11D3/38645 ,  C12N9/2434 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021 ,  C12Y302/01091 ,  C12Y302/01176

摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。

公开(公告)号：US20060068235A1

公开(公告)日：2006-03-30

申请号：US10950714

申请日：2004-09-27

申请人： Gennady Resnick ,  Jung Yi ,  Tadahiko Taniguchi ,  Akira Maekawa

发明人： Gennady Resnick ,  Jung Yi ,  Tadahiko Taniguchi ,  Akira Maekawa

IPC分类号： H01M8/00

CPC分类号： H01M8/04253 ,  H01M8/04007 ,  H01M8/249

摘要： A plurality of fuel cell stacks (8, 8a, 9, 9a) have their cathode ends (11, 12) contiguous with either a common current collector (15a-15d) or respective current collectors (15a, 15b) which may be separated by electrical isolation (27a, 27b). The cathode-to-cathode relationship protects the cathode of each of the stacks from cold ambient environments, thereby permitting improved cold starts and mitigation of performance loss as a result of cold starts as well as freeze/thaw cycles. Heaters (30, 30a-30d) may be provided in current collectors, or in or between electrical isolation. Four stacks may share one current collector, or each may have its own current collector.

摘要翻译： 多个燃料电池堆（8,8a，9,9a）的阴极端（11,12）与公共集电器（15a-15d）或相应的集电器（15a，15b）相连接 ），其可以通过电隔离（27a，27b）分离。 阴极到阴极的关系保护了每个堆叠的阴极与冷的环境环境，从而允许由于冷启动以及冷冻/融化循环而导致的冷启动和降低性能损失。 加热器（30,30a-30d）可以设置在集电器中，或在电隔离之间或之间。 四个堆叠可以共享一个集电器，或者每个可以具有其自己的集电器。

公开(公告)号：US20070254909A1

公开(公告)日：2007-11-01

申请号：US10585029

申请日：2004-12-30

申请人： Hyung Kim ,  Nam Lee ,  Joo Kim ,  Hae Rhee ,  Yong-Baik Cho ,  Je Ryu ,  Nam Kim ,  Keun Ryu ,  Jung Yi ,  Jae Jung

发明人： Hyung Kim ,  Nam Lee ,  Joo Kim ,  Hae Rhee ,  Yong-Baik Cho ,  Je Ryu ,  Nam Kim ,  Keun Ryu ,  Jung Yi ,  Jae Jung

IPC分类号： A61K31/4375 ,  A61K31/436 ,  A61P29/00 ,  A61P37/00 ,  C07D471/04 ,  C07D491/052

CPC分类号： C07D471/04 ,  C07D491/052

摘要： The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

摘要翻译： 本发明涉及具有抑制细胞因子产生抑制作用的新型吡啶衍生物，其涉及炎性反应，因此表明其用作治疗与炎症，免疫，慢性炎症有关的疾病的治疗剂以及具有抗炎作用的药物， 炎症和镇痛作用。 此外，本发明涉及其制造方法和含有该组合物的药物组合物。

公开(公告)号：US20080064687A1

公开(公告)日：2008-03-13

申请号：US11727413

申请日：2007-03-26

申请人： Young Suh ,  Uh Oh ,  Hee Kim ,  Jee Lee ,  Hyeung Park ,  Ok Park ,  Yong Lee ,  Young Park ,  Yung Joo ,  Jin Choi ,  Kyung Lim ,  Sun Kim ,  Jin Kim ,  Hyun Koh ,  Joo Moh ,  Yeon Jeong ,  Jung Yi ,  Young Oh

发明人： Young Suh ,  Uh Oh ,  Hee Kim ,  Jee Lee ,  Hyeung Park ,  Ok Park ,  Yong Lee ,  Young Park ,  Yung Joo ,  Jin Choi ,  Kyung Lim ,  Sun Kim ,  Jin Kim ,  Hyun Koh ,  Joo Moh ,  Yeon Jeong ,  Jung Yi ,  Young Oh

IPC分类号： C07C335/02 ,  A61K31/155 ,  A61K31/17 ,  A61K31/215 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/5375 ,  A61K31/54 ,  A61P1/00 ,  A61P11/00 ,  A61P25/00 ,  C07D403/02 ,  C07D333/22 ,  C07D307/02 ,  C07D279/12 ,  C07D279/06 ,  C07D277/30 ,  C07D265/30 ,  C07D241/04 ,  C07D231/56 ,  C07D211/70 ,  C07D209/18 ,  C07D207/30 ,  A61P9/00 ,  C07C257/00 ,  C07C275/18

CPC分类号： C07D333/42 ,  C07C311/08 ,  C07C311/47 ,  C07C333/20 ,  C07C335/12 ,  C07C335/14 ,  C07C335/20 ,  C07C335/26 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/323 ,  C07D207/416 ,  C07D207/42 ,  C07D209/08 ,  C07D209/14 ,  C07D213/40 ,  C07D213/61 ,  C07D213/76 ,  C07D217/06 ,  C07D231/14 ,  C07D231/56 ,  C07D233/64 ,  C07D235/14 ,  C07D239/42 ,  C07D241/12 ,  C07D241/24 ,  C07D277/28 ,  C07D295/13 ,  C07D295/215 ,  C07D295/32 ,  C07D307/52 ,  C07D311/58 ,  C07D317/58 ,  C07D333/20

摘要： The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

摘要翻译： 本发明涉及作为香草素受体（VR）的调节剂的新型硫脲衍生物以及含有它们的药物组合物。 作为与香草素受体活动有关的疾病，疼痛急性疼痛，慢性疼痛，神经性疼痛，手术后疼痛，偏头痛，关节痛，神经病变，神经损伤，糖尿病性神经病变，神经变性，神经性皮肤病，中风，膀胱过敏反应，易怒 肠综合征，哮喘或慢性阻塞性肺疾病等呼吸系统疾病，皮肤，眼睛或粘膜的刺激​​，发热，胃十二指肠溃疡，炎性肠病和炎症性疾病。 本发明提供了用于预防或治疗这些疾病的药物组合物。

公开(公告)号：US20130335772A1

公开(公告)日：2013-12-19

申请号：US13525651

申请日：2012-06-18

申请人： Marquis Waller ,  Jung Yi ,  Daria Tolmacheva ,  Norris Xu

发明人： Marquis Waller ,  Jung Yi ,  Daria Tolmacheva ,  Norris Xu

IPC分类号： G06K15/02

CPC分类号： G06F3/1292 ,  G06F3/1204 ,  G06F3/1229 ,  G06F3/1253 ,  G06F3/1259 ,  G06F3/1288 ,  H04N1/00233 ,  H04N1/00244 ,  H04N1/00307 ,  H04N1/00344 ,  H04N1/00477 ,  H04N1/32106 ,  H04N1/32523 ,  H04N2201/0082 ,  H04N2201/3204 ,  H04N2201/3205 ,  H04N2201/3219 ,  H04N2201/3273 ,  H04N2201/3278

摘要： Systems and methods are provided for interactions between print servers and mobile phones. One embodiment is a mobile phone comprising a memory, a transceiver, and a control unit. The memory is operable to store rules for interacting with printers, and the transceiver is operable to communicate with a wireless telecommunication network via radio frequency transmissions. The control unit is operable to receive a notification from a print server via the transceiver that indicates status information for a printer controlled by the print server, to determine actions available for the printer based on the stored rules and the status information, and to generate a Graphical User Interface (GUI) that displays interactive graphical elements selectable by a user to initiate the available actions for the printer.

摘要翻译： 为打印服务器和手机之间的交互提供了系统和方法。 一个实施例是包括存储器，收发器和控制单元的移动电话。 存储器可操作地存储与打印机交互的规则，并且收发器可操作以经由无线电频率传输与无线电信网络进行通信。 控制单元可操作以经由收发器接收来自打印服务器的通知，该收发器指示由打印服务器控制的打印机的状态信息，以基于所存储的规则和状态信息确定可用于打印机的动作，并且生成 图形用户界面（GUI），显示用户可选择的交互式图形元素，以启动打印机的可用操作。

公开(公告)号：US20070298290A1

公开(公告)日：2007-12-27

申请号：US11888709

申请日：2007-08-02

申请人： Timothy Bekkedahl ,  Lawrence Bregoli ,  Ned Cipollini ,  Timothy Patterson ,  Marianne Pemberton ,  Jonathan Puhalski ,  Carl Reiser ,  Richard Sawyer ,  Margaret Steinbugler ,  Jung Yi

发明人： Timothy Bekkedahl ,  Lawrence Bregoli ,  Ned Cipollini ,  Timothy Patterson ,  Marianne Pemberton ,  Jonathan Puhalski ,  Carl Reiser ,  Richard Sawyer ,  Margaret Steinbugler ,  Jung Yi

IPC分类号： H01M8/04 ,  H01M8/00

CPC分类号： H01M8/04029 ,  H01M8/0243 ,  H01M8/0245 ,  H01M8/0258 ,  H01M8/0267 ,  H01M8/0271 ,  H01M8/04089 ,  H01M8/04097 ,  H01M8/04119 ,  H01M8/04156 ,  H01M8/04291 ,  H01M8/1007 ,  H01M2008/1095 ,  H01M2250/10 ,  Y02B90/14

摘要： A fuel cell power plant (10) includes a fuel cell (12) having a membrane electrode assembly (MEA) (16), disposed between an anode support plate (14) and a cathode support plate (18), the anode and/or cathode support plates include a hydrophilic substrate layer (80, 82) having a predetermined pore size. The pressure of the reactant gas streams (22, 24) is greater than the pressure of the coolant stream (26), such that a greater percentage of the pores within the hydrophilic substrate layer contain reactant gas rather than water. Any water that forms on the cathode side of the MEA will migrate through the cathode support plate and away from the MEA. Controlling the pressure also ensures that the coolant water will continually migrate from the coolant stream toward the anode side of the MEA, thereby preventing the membrane from becoming dry. Proper pore size and a pressure differential between coolant and reactants improves the electrical efficiency of the fuel cell.

摘要翻译： 燃料电池发电厂（10）包括具有设置在阳极支撑板（14）和阴极支撑板（18）之间的膜电极组件（MEA）（16））的燃料电池（12），阳极和/或 阴极支撑板包括具有预定孔径的亲水基底层（80,82）。 反应物气体流（22,24）的压力大于冷却剂流（26）的压力，使得亲水基底层内的较大百分比的孔含有反应物气体而不是水。 在MEA的阴极侧形成的任何水将通过阴极支撑板迁移并远离MEA。 控制压力还可确保冷却水从冷却剂流向MEA的阳极侧连续迁移，从而防止膜变干。 冷却剂和反应物之间适当的孔径和压力差提高了燃料电池的电效率。