公开(公告)号：US20180259475A1

公开(公告)日：2018-09-13

申请号：US15886723

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： ShuaiGang XIAO ,  David S. KUO ,  Xiaomin YANG ,  Kim Yang LEE ,  Yautzong HSU ,  Michael R. FELDBAUM

IPC: G01N27/327 ,  C12Q1/6869 ,  G01N33/487 ,  B82Y5/00

CPC classification number: G01N27/3278 ,  B82Y5/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/607 ,  C12Q2565/631

Abstract: A DNA sequencing device, and related method, which include a nanopore having a maximum width dimension of no greater than about 50 nm, and a pair of electrodes having a spacing of no greater than about 2 nm, the electrodes being exposed within the nanopore to measure a DNA strand passing through the nanopore.

公开(公告)号：US20180223354A1

公开(公告)日：2018-08-09

申请号：US15886483

申请日：2018-02-01

Applicant: Seagate Technology LLC

Inventor： Thomas Young CHANG ,  Kim Yang LEE ,  David S. KUO ,  Erik J. HUTCHINSON

IPC: C12Q1/6869 ,  G01N33/487 ,  B01L3/00 ,  G01N27/447

CPC classification number: C12Q1/6869 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0896 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Apparatus and methods to a DNA sequencing device and related methods that includes a substrate, a nanochannel formed in the substrate, a first electrode, a second electrode arranged opposite the first electrode, a distance between the first and second electrodes defining an electrode gap that is exposed within the nanochannel, and at least one actuator operable to move at least one of the first and second electrodes to adjust a size of the electrode gap.

公开(公告)号：US20180246057A1

公开(公告)日：2018-08-30

申请号：US15886608

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Thomas Young CHANG ,  David S. KUO ,  Kim Yang LEE ,  Koichi WAGO

IPC: G01N27/447 ,  C12Q1/6874 ,  G01N33/487 ,  B01L3/00

Abstract: A DNA sequencing device, and related method, which include an electrode and a plurality of spaced apart alignment structures. The electrode defines an electrode gap, the electrode being operable to detect a change in tunneling current as a DNA strand passes through the electrode gap. The plurality of spaced apart alignment structures are arranged to position nucleotides of the DNA strand in a predetermined orientation as the DNA strand passes through the electrode gap.

公开(公告)号：US20180216179A1

公开(公告)日：2018-08-02

申请号：US15886533

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Xiaomin YANG ,  ShuaiGang XIAO ,  David S. KUO ,  Koichi WAGO ,  Thomas Young CHANG

IPC: C12Q1/6869 ,  C12M1/34

CPC classification number: C12Q1/6869 ,  B82Y15/00 ,  C12M1/34 ,  C12Q2563/159 ,  C12Q2565/607 ,  C12Q2565/629

Abstract: Apparatus and methods relating to DNA sequencing are provided. In one embodiment, a DNA sequencing device includes a nanochannel having a width that is approximately 0.3 nm to approximately 20 nm. A pair of electrodes having portions exposed to the nanochannel may form a tunneling current electrode (TCE) with an electrode gap of approximately 0.1 nm to approximately 2 nm, and more particularly about 0.3 nm to about 1 nm. In one embodiment, at least one of the pair of electrodes is formed as a suspended electrode. An actuator may be associated with the suspended electrode to displace it relative to the other electrode. In various embodiments, the nanochannel and/or the electrodes may be formed using thermal reflow processes to reduce the size of such features.

公开(公告)号：US20170307976A1

公开(公告)日：2017-10-26

申请号：US15517505

申请日：2014-11-18

Applicant: Seagate Technology LLC

Inventor： XiaoMin YANG ,  Shuaigang XIAO ,  Kim Y. LEE ,  David S. KUO

IPC: G03F7/11 ,  G03F7/20 ,  G03F7/09

CPC classification number: G03F7/11 ,  B81C1/00031 ,  B81C2201/0149 ,  C08L53/00 ,  G03F7/0002 ,  G03F7/094 ,  G03F7/165 ,  G03F7/168 ,  G03F7/40 ,  G03F7/70 ,  H01L21/0274

Abstract: Provided herein is a method, including creating a first layer over a substrate, wherein the first layer is configured for directed self-assembly of a block copolymer thereover; creating a continuous second layer over the first layer by directed self-assembly of a block copolymer, wherein the second layer is also configured for directed self-assembly of a block copolymer thereover; and creating a third layer over the continuous second layer by directed self-assembly of a block copolymer. Also provided is an apparatus, comprising a continuous first layer comprising a thin film of a first, phase-separated block copolymer, wherein the first layer comprises a first chemoepitaxial template configured for directed self-assembly of a block copolymer thereon; and a second layer on the first layer, wherein the second layer comprises a thin film of a second, phase-separated block copolymer.

公开(公告)号：US20210115508A1

公开(公告)日：2021-04-22

申请号：US17137837

申请日：2020-12-30

Applicant: Seagate Technology LLC

Inventor： Xiaomin YANG ,  ShuaiGang XIAO ,  David S. KUO ,  Koichi WAGO ,  Thomas Young CHANG

IPC: C12Q1/6869 ,  C12M1/34

Abstract: Apparatus and methods relating to DNA sequencing are provided. In one embodiment, a DNA sequencing device includes a nanochannel having a width that is approximately 0.3 nm to approximately 20 nm. A pair of electrodes having portions exposed to the nanochannel may form a tunneling current electrode (TCE) with an electrode gap of approximately 0.1 nm to approximately 2 nm, and more particularly about 0.3 nm to about 1 nm. In one embodiment, at least one of the pair of electrodes is formed as a suspended electrode. An actuator may be associated with the suspended electrode to displace it relative to the other electrode. In various embodiments, the nanochannel and/or the electrodes may be formed using thermal reflow processes to reduce the size of such features.

公开(公告)号：US20200371064A1

公开(公告)日：2020-11-26

申请号：US16940486

申请日：2020-07-28

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Thomas Young CHANG ,  David S. KUO ,  Kim Yang LEE ,  Koichi WAGO

IPC: G01N27/447 ,  B01L3/00 ,  G01N33/487 ,  C12Q1/6869 ,  B82Y15/00

Abstract: A DNA sequencing device, and related method, which include an electrode and a plurality of spaced apart alignment structures. The electrode defines an electrode gap, the electrode being operable to detect a change in tunneling current as a DNA strand passes through the electrode gap. The plurality of spaced apart alignment structures are arranged to position nucleotides of the DNA strand in a predetermined orientation as the DNA strand passes through the electrode gap.

公开(公告)号：US20200240947A1

公开(公告)日：2020-07-30

申请号：US16845565

申请日：2020-04-10

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： ShuaiGang XIAO ,  David S. KUO ,  Xiaomin YANG ,  Kim Yang LEE ,  Yautzong HSU ,  Michael R. FELDBAUM

IPC: G01N27/327 ,  C12Q1/6869 ,  G01N33/487

Abstract: A DNA sequencing device and methods of making. The device includes a pair of electrodes having a spacing of no greater than about 2 nm, the electrodes being exposed within a nanopore to measure a DNA strand passing through the nanopore. The device can be made by depositing a conductive layer over a sacrificial channel and then removing the sacrificial channel to form the electrode gap.

公开(公告)号：US20200249195A1

公开(公告)日：2020-08-06

申请号：US16854607

申请日：2020-04-21

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： David S. KUO ,  Xiaomin YANG ,  ShuaiGang XIAO ,  Kim Yang LEE ,  Koichi R. WAGO ,  Thomas Young CHANG

IPC: G01N27/327 ,  C12Q1/6869 ,  G01N33/487 ,  B01L3/00 ,  B81C1/00

Abstract: A DNA sequencing device, and related methods, include a nanopore or nanochannel structure, and a nanoelectrode. The nanoelectrode includes electrode members having free ends exposed within the nanopore or nanochannel structure, an electrode gap defined between of the free ends, and plated portions formed on the free ends to provide a reduced sized for the electrode gap.

公开(公告)号：US20180258480A1

公开(公告)日：2018-09-13

申请号：US15886736

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Thomas Young CHANG ,  Philip L. STEINER ,  Kim Yang LEE ,  David S. KUO

IPC: C12Q1/6869 ,  C40B40/06

Abstract: Apparatus and methods to identify nucleotides of a DNA strand. The method includes exposing the DNA strand to a first dye or peptide, attaching the first dye or peptide to a first type of nucleotide (A,T,C,G) of the DNA strand, the first dye or peptide changing a conductance of the first type of nucleotide to which the first dye or peptide is attached, and measuring a tunneling current signal for all nucleotides of the DNA strand, the changed conductance of the first type of nucleotide providing amplified tunneling current discrimination of the nucleotides of the DNA strand.