公开(公告)号：US4275300A

公开(公告)日：1981-06-23

申请号：US953380

申请日：1978-10-23

Applicant: Seth R. Abbott

Inventor： Seth R. Abbott

IPC: C09K11/02 ,  G01T1/00 ,  G01T1/203 ,  G01T1/10 ,  C09K11/06 ,  C09K11/20 ,  G01N23/00 ,  G01N23/22 ,  G01N31/08 ,  G01T1/20

CPC classification number: C09K11/025 ,  G01T1/003 ,  G01T1/203

Abstract: A fluorescent composition useful in thin-layer chromatography comprises an inert porous particle having a fluorescent material fixedly attached by covalent chemical bonding to the surface thereof. A process for synthesizing this fluorescent composition is disclosed. A method for detecting the radioactivity of a radioactive species using a cell packed with such a fluorescent composition is also disclosed.

Abstract translation: 用于薄层色谱的荧光组合物包括具有荧光材料的惰性多孔颗粒，其通过共价键合固定在其表面上。 公开了一种合成该荧光组合物的方法。 还公开了使用填充有这种荧光组合物的电池来检测放射性物质的放射性的方法。

公开(公告)号：US4290892A

公开(公告)日：1981-09-22

申请号：US16847

申请日：1979-03-02

Applicant: Seth R. Abbott

Inventor： Seth R. Abbott

IPC: B01J41/20 ,  G01N30/96 ,  G01T1/00 ,  G01T1/203 ,  B01D15/08

CPC classification number: G01N30/482 ,  B01J41/20 ,  G01N30/96 ,  G01T1/003 ,  G01T1/203 ,  B01J2220/54

Abstract: A weak anion exchange composition useful in polyfunctional compound chromatographic separations comprises an inert porous particle having a tetra-substituted silane material fixedly attached by covalent bonding to the surface thereof. A process for synthesizing the weak anion exchange composition is disclosed together with methods for separation of polyfunctional compounds and their isomers using a column packed with such weak anion exchange composition.

Abstract translation: 用于多官能化合物色谱分离的弱阴离子交换组合物包括具有四取代的硅烷材料的惰性多孔颗粒，其通过共价键与其表面固定连接。 公开了一种用于合成弱阴离子交换组合物的方法以及使用填充有这种弱阴离子交换组合物的柱分离多官能化合物及其异构体的方法。

公开(公告)号：US4378500A

公开(公告)日：1983-03-29

申请号：US242194

申请日：1981-03-10

Applicant: Seth R. Abbott ,  Robert Cunico

Inventor： Seth R. Abbott ,  Robert Cunico

IPC: B01J20/281 ,  G01N21/64 ,  G01N21/34

CPC classification number: G01N30/48 ,  B01J20/281 ,  G01N21/64 ,  B01J2220/54

Abstract: A method for fluorescence enhancement of dansyl derivatives of active hydrogen compounds which are easily separated in a liquid chromatography column using a polar solvent system but whose fluorescence efficiency is diminished in such polar solvents, by changing the environment of the dansyl derivative without changing the solvent.

Abstract translation: 荧光增强活性氢化合物的丹磺酰衍生物的方法，其通过在不改变溶剂的情况下改变丹酰基衍生物的环境，在液相色谱柱中使用极性溶剂体系容易地分离，但在这些极性溶剂中荧光效率降低。

公开(公告)号：US4298500A

公开(公告)日：1981-11-03

申请号：US146711

申请日：1980-05-05

Applicant: Seth R. Abbott

Inventor： Seth R. Abbott

IPC: B01J20/286 ,  B01D15/08 ,  B01J20/10 ,  B01J20/281 ,  B01J20/287 ,  B01J20/32 ,  B01J39/26 ,  B01J41/20 ,  C12N15/10 ,  G01N30/88

CPC classification number: B01J20/287 ,  B01J20/28004 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3227 ,  B01J20/3257 ,  B01J20/3259 ,  B01J20/3263 ,  B01J20/3285 ,  B01J39/26 ,  B01J41/20 ,  C12N15/101 ,  B01J2220/54 ,  B01J2220/58

Abstract: The mixed phase packing material of this invention, enables rapid separation of multi-sited biopolymers. This separation is achieved by "tailoring" the distance between organo-silyl groups covalently bonded to the rigid support at the Angstrom distance needed for reversible separation of the biopolymers of interest and "capping" other sterically available active sites on the support with a relatively inert compound.

Abstract translation: 本发明的混合相包装材料能够快速分离多种生物聚合物。 这种分离是通过以相对惰性的方式可逆分离感兴趣的生物聚合物和“封盖”其它空间上的活性位点所需的距离处所需的距离“定制”共价键合到刚性载体上的有机甲硅烷基之间的距离来实现的 复合。

公开(公告)号：US4430496A

公开(公告)日：1984-02-07

申请号：US359173

申请日：1982-03-16

Applicant: Seth R. Abbott

Inventor： Seth R. Abbott

IPC: B01J20/32 ,  B01J41/10 ,  C07H17/00 ,  B01D15/08

CPC classification number: B01J41/10 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28083 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3257 ,  B01J41/043 ,  B01J41/085 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

Abstract: A strong anion exchange composition useful in monophosphate nucleotide isomer separations is comprised of an inert porous particle having a silyl alkyl ammonium compound fixedly attached by a covalent silicon-oxygen-silicon bond to the surface thereof. A process for synthesizing the strong anion exchange composition in an aqueous solvent is disclosed together with methods for separation of monophosphate nucleotide isomers, highly phophorylated nucleotides and aldopentose carbohydrates using a column packed with this strong anion exchange composition.

Abstract translation: 用于单磷酸核苷酸异构体分离的强阴离子交换组合物由具有通过共价硅 - 氧 - 硅键固定连接到其表面的甲硅烷基烷基铵化合物的惰性多孔颗粒组成。 公开了一种用于在水性溶剂中合成强阴离子交换组合物的方法以及使用填充有该强阴离子交换组合物的柱分离单磷酸核苷酸异构体，高度磷酸化核苷酸和戊糖醛糖碳水化合物的方法。

公开(公告)号：US4396528A

公开(公告)日：1983-08-02

申请号：US271861

申请日：1981-06-09

Applicant: Seth R. Abbott

Inventor： Seth R. Abbott

IPC: C09K11/02 ,  G01N30/93 ,  G01T1/00 ,  G01T1/20 ,  G01T1/203 ,  C09K11/06 ,  C09K11/20

CPC classification number: C09K11/025 ,  G01N30/93 ,  G01T1/003 ,  G01T1/20 ,  G01T1/203

Abstract: A fluorescent composition useful in thin-layer chromatography comprises an inert porous particle having a fluorescent material fixedly attached by covalent chemical bonding to the surface thereof. A process for synthesizing this fluorescent composition is disclosed. A method for detecting the radioactivity of a radioactive species using a cell packed with such a fluorescent composition is also disclosed.

Abstract translation: 用于薄层色谱的荧光组合物包括具有荧光材料的惰性多孔颗粒，其通过共价键合固定在其表面上。 公开了一种合成该荧光组合物的方法。 还公开了使用填充有这种荧光组合物的电池来检测放射性物质的放射性的方法。

公开(公告)号：US4340496A

公开(公告)日：1982-07-20

申请号：US271903

申请日：1981-06-09

Applicant: Seth R. Abbott

Inventor： Seth R. Abbott

IPC: B01J20/32 ,  B01J41/08 ,  B01J41/20 ,  C09K11/02 ,  G01T1/00 ,  G01T1/203 ,  B01D15/08 ,  B01J41/06

CPC classification number: G01T1/203 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3257 ,  B01J41/08 ,  B01J41/20 ,  C09K11/025 ,  G01T1/003

Abstract: A weak anion exchange composition useful in polyfunctional compound chromatographic separations comprises an inert porous particle having a tetra-substituted silane material fixedly attached by covalent bonding to the surface thereof. A process for synthesizing the weak anion exchange composition is disclosed together with methods for separation of polyfunctional compounds and their isomers using a column packed with such weak anion exchange composition.

Abstract translation: 用于多官能化合物色谱分离的弱阴离子交换组合物包括具有四取代的硅烷材料的惰性多孔颗粒，其通过共价结合固定在其表面上。 公开了一种用于合成弱阴离子交换组合物的方法以及使用填充有这种弱阴离子交换组合物的柱分离多官能化合物及其异构体的方法。

公开(公告)号：US4322542A

公开(公告)日：1982-03-30

申请号：US112964

申请日：1980-01-17

Applicant: Seth R. Abbott

Inventor： Seth R. Abbott

IPC: B01J20/281 ,  B01J20/32 ,  B01J41/08 ,  B01J41/10 ,  C07H19/10 ,  C07H19/20 ,  G01N30/88 ,  C07F7/10

CPC classification number: B01J41/20 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28083 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3257 ,  B01J2220/54 ,  B01J2220/58

Abstract: A strong anion exchange composition useful in monophosphate nucleotide isomer separations is comprised of an inert porous particle having a silyl alkyl ammonium compound fixedly attached by a covalent silicon-oxygen-silicon bond to the surface thereof. A process for synthesizing the strong anion exchange composition in an aqueous solvent is disclosed together with methods for separation of monophosphate nucleotide isomers, highly phosphorylated nucleotides and aldopentose carbohydrates using a column packed with this strong anion exchange composition.

Abstract translation: 用于单磷酸核苷酸异构体分离的强阴离子交换组合物由具有通过共价硅 - 氧 - 硅键固定连接到其表面的甲硅烷基烷基铵化合物的惰性多孔颗粒组成。 公开了一种在水性溶剂中合成强阴离子交换组合物的方法以及使用填充有该强阴离子交换组合物的柱分离单磷酸核苷酸异构体，高度磷酸化的核苷酸和戊糖醛糖的方法。