公开(公告)号：US20050192547A1

公开(公告)日：2005-09-01

申请号：US10633204

申请日：2003-07-30

Applicant: Shanta Modak ,  Suhas Tambe ,  Lester Sampath

Inventor： Shanta Modak ,  Suhas Tambe ,  Lester Sampath

IPC: A01N47/44 ,  A61L29/16 ,  A61M25/00

CPC classification number: A61L29/16 ,  A01N47/44 ,  A61L2300/102 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/45 ,  A01N59/16 ,  A01N37/44 ,  A01N25/34 ,  A01N25/10 ,  A01N2300/00

Abstract: The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

Abstract translation: 本发明涉及包含一种或多种防腐剂与抗生素组合的组合物。 至少部分地基于这样的发现，即这种组合倾向于阻止抗生素抗性生物的形成。 在本发明的非限制性实施方案中，抗生素是二甲胺四环素，并且所述防腐剂是氯己定化合物，三氯生或苯扎氯铵，并且在具体实施方案中，加入银盐或铋盐。 本发明的具体的非限制性实施方案的实例包括（i）米诺环素，三氯生和铋盐的组合; （ii）米诺环素，氯己定化合物和铋盐; 和（iii）米诺环素，苯扎氯铵和铋盐。 本发明还提供了已经用抗菌素和抗生素组合处理或以其他方式组合的制品，例如但不限于医疗制品。

公开(公告)号：US06224579B1

公开(公告)日：2001-05-01

申请号：US09281872

申请日：1999-03-31

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A61M532

CPC classification number: A61L31/16 ,  A01N59/16 ,  A61L2/18 ,  A61L15/44 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/21 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/45 ,  D06M11/83 ,  D06M13/432 ,  D06M16/00 ,  Y10T428/1352 ,  A01N31/16 ,  A01N31/12 ,  A01N31/08 ,  A01N25/34 ,  A01N2300/00

Abstract: The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

Abstract translation: 本发明涉及包含三氯生和含银化合物的组合的聚合物医疗制品。 至少部分地是基于发现这些试剂协同作用，从而允许使用相对较低水平的两种试剂。 虽然以前已经发现三氯生与氯己定联合使用时可能特别有用，但是已经进一步发现，根据本发明，可以制备具有合适的抗微生物性质的医药制品，其含有不含氯己定的三氯生。 这样的医疗制品具有预防或抑制感染的优点，同时避免对氯己定具有敏感性的个体对氯己定的不良不良反应。

公开(公告)号：US5985918A

公开(公告)日：1999-11-16

申请号：US760054

申请日：1996-12-04

Applicant: Shanta Modak ,  Lester Sampath ,  Lauserpina Caraos

Inventor： Shanta Modak ,  Lester Sampath ,  Lauserpina Caraos

IPC: A61K31/60 ,  A61K31/625 ,  A61K31/315 ,  A61K31/19 ,  A61K31/20

CPC classification number: A61K31/60 ,  A61K31/625 ,  Y10S514/886 ,  Y10S514/887

Abstract: The present invention relates to the use of organic salts of zinc in topical formulations. Such organic salts tend to be less water soluble and therefore less likely to result in systemic toxicity, even with chronic use. In preferred embodiments, the composition of the invention comprise zinc salicylate, which provides the antiinflammatory effect of salicylate, but wherein the zinc moiety counteracts toxic effects associated with salicylate.

Abstract translation: 本发明涉及在局部制剂中使用锌的有机盐。 这种有机盐倾向于较少的水溶性，因此即使在慢性使用时也不太可能导致全身毒性。 在优选实施方案中，本发明的组合物包含水杨酸锌，其提供水杨酸盐的抗炎作用，但其中锌部分抵消与水杨酸盐相关的毒性作用。

公开(公告)号：US5487896A

公开(公告)日：1996-01-30

申请号：US241474

申请日：1994-05-12

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A01N25/34 ,  A01N47/44 ,  A41D19/00 ,  A61B19/04 ,  A61K7/043

CPC classification number: A41D19/0062 ,  A01N25/34 ,  A01N47/44 ,  A61B42/00

Abstract: The present invention relates to an antimicrobial glove which exhibits rapid release of the antiinfective agent chlorhexidine. It is based, at least in part, on the discovery that when a slurry having a high ratio of chlorhexidine to starch lubricant, where the percentage of starch lubricant is between 7 and 10 percent, is used to coat the inner surface of a latex glove, the resulting antimicrobial activity is available surprisingly quickly, within about 30 seconds to one minute of exposure to liquid. This rapid release of antiinfective agent may be explained by the presence, in gloves according to the invention, of two matrix layers, one comprising the starch lubricant, the other comprising latex in the body of the glove in immediate apposition to the lubricant, both of which are supersaturated with chlorhexidine.

Abstract translation: 本发明涉及抗感染剂氯己定的快速释放的抗微生物手套。 至少部分地基于以下发现：当使用具有高比例的洗必太与淀粉润滑剂（其中淀粉润滑剂的百分比为7至10％）的浆料涂覆在乳胶手套的内表面 ，在暴露于液体的约30秒至1分钟内，所得到的抗微生物活性可以惊人地快速地获得。 这种抗感染剂的快速释放可以通过在根据本发明的手套中存在两个基质层来解释，所述两个基质层包括淀粉润滑剂，另一个包括与润滑剂紧密结合的手套体内的胶乳， 其用氯己定过饱和。

公开(公告)号：US08436050B2

公开(公告)日：2013-05-07

申请号：US10785207

申请日：2004-02-24

Applicant: Shanta Modak ,  Trupti A. Gaonkar ,  Lauser Caraos ,  Lester Sampath

Inventor： Shanta Modak ,  Trupti A. Gaonkar ,  Lauser Caraos ,  Lester Sampath

IPC: A01N33/12 ,  A61K31/08 ,  A61K31/047

CPC classification number: A61K8/042 ,  A61K8/347 ,  A61K8/416 ,  A61K8/43 ,  A61K31/79 ,  A61K2800/75 ,  A61Q17/005

Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.

Abstract translation: 在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。 在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。 优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。 不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。 含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合， 润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

公开(公告)号：US08293802B2

公开(公告)日：2012-10-23

申请号：US12853977

申请日：2010-08-10

Applicant: Shanta Modak ,  Trupti A. Gaonkar ,  Lauserpina Algenio Caraos ,  Lester Sampath

Inventor： Shanta Modak ,  Trupti A. Gaonkar ,  Lauserpina Algenio Caraos ,  Lester Sampath

IPC: A61K31/08

CPC classification number: A61K8/042 ,  A61K8/347 ,  A61K8/416 ,  A61K8/43 ,  A61K31/79 ,  A61K2800/75 ,  A61Q17/005

Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.

Abstract translation: 在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。 在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。 优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。 不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。 含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合， 润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

公开(公告)号：US20050124725A1

公开(公告)日：2005-06-09

申请号：US11031607

申请日：2005-01-06

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A01N59/16 ,  A61L2/18 ,  A61L15/44 ,  A61L17/00 ,  A61L27/54 ,  A61L29/00 ,  A61L29/16 ,  A61L31/16 ,  C08K3/00

CPC classification number: A61L31/16 ,  A01N59/16 ,  A61L2/18 ,  A61L15/44 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/21 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/45 ,  D06M11/83 ,  D06M13/432 ,  D06M16/00 ,  Y10T428/1352 ,  A01N31/16 ,  A01N31/12 ,  A01N31/08 ,  A01N25/34 ,  A01N2300/00

Abstract: The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

公开(公告)号：US06846846B2

公开(公告)日：2005-01-25

申请号：US10047631

申请日：2001-10-23

Applicant: Shanta Modak ,  Trupti A. Gaonkar ,  Lester Sampath

Inventor： Shanta Modak ,  Trupti A. Gaonkar ,  Lester Sampath

IPC: A61K8/04 ,  A61K8/34 ,  A61K8/41 ,  A61K8/43 ,  A61K31/79 ,  A61Q17/00 ,  A61Q19/00 ,  A61K31/08 ,  A61K7/32 ,  A61K31/14 ,  A61K31/27

CPC classification number: A61K8/042 ,  A61K8/347 ,  A61K8/416 ,  A61K8/43 ,  A61K31/79 ,  A61K2800/75 ,  A61Q17/005

Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.

Abstract translation: 在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。 在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。 优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。 不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。

公开(公告)号：US06626873B1

公开(公告)日：2003-09-30

申请号：US09618432

申请日：2000-07-18

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A61M532

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1331 ,  Y10T428/1352 ,  A61L29/06 ,  C08L83/04 ,  C08L75/04 ,  A61L27/507

Abstract: The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.

Abstract translation: 本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。 至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性 疏水聚合物。 也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。 根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

公开(公告)号：US6106505A

公开(公告)日：2000-08-22

申请号：US101129

申请日：1998-06-30

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A61L15/44 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M5/32

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1331 ,  Y10T428/1352

Abstract: The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.

Abstract translation: PCT No.PCT / US96 / 20932 Sec。 371日期1998年6月30日第 102（e）日期1998年6月30日PCT 1996年12月23日PCT PCT。 公开号WO97 / 25085 日期1997年7月17日本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。 至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性 疏水聚合物。 也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。 根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。