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1.发明申请Reagent for Lacrimation Examination and Method of Lacrimation Examination 审中-公开Lacrimation考试和Lacrimation考试方法试剂公开(公告)号：US20070282012A1
公开(公告)日：2007-12-06
申请号：US10586326
申请日：2005-01-11
申请人： Shigeru Kinoshita , Norihiko Yokoi , Hisayo Higashihara , Nobuo Shiomi , Shinsuke Imai , Nobuaki Tsuge , Kentaro Horie
发明人： Shigeru Kinoshita , Norihiko Yokoi , Hisayo Higashihara , Nobuo Shiomi , Shinsuke Imai , Nobuaki Tsuge , Kentaro Horie
IPC分类号： A61K31/095 , A61P27/02 , G01N33/487
CPC分类号： A61K31/095 , A61B3/101
摘要： A new application of the dacryogenic component of onions and analogues of the component in the medicinal field. It is a reagent for lacrimation examination which contains as an active ingredient a compound represented by the following chemical formula: wherein R represents a C1-5 alkyl chain.
摘要翻译： 在药用领域中组分的洋葱和类似物的致冷组分的新应用。 作为流体检查用试剂，其含有作为活性成分的化合物，由以下化学式表示：其中R表示C 1-5烷基链。
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公开(公告)号：US08996097B2
公开(公告)日：2015-03-31
申请号：US11434657
申请日：2006-05-15
CPC分类号： A61B3/101 , A61B3/10 , A61B3/14 , A61B5/0071 , A61B2576/02 , A61M2210/0612 , G06T7/0014 , G06T2207/30041
摘要： In an ophthalmic measuring method, a traceable marker in particulate form is administered to the lachrymal fluid of a subject's eye, and the lachrymal fluid is irradiated with illuminating light. Images of the illuminated lachrymal fluid are electronically captured respectively at different times. Two images from among the captured images are selected, with each of the two selected images displaying the traceable marker. A characteristic point of each of the two selected images is specified. A movement speed of the traceable marker is measured based on positions thereof in the two selected images and on a time difference from specifying the characteristic point of one of the two selected images to specifying the characteristic point of the other of the two selected images. The measured movement speed of the traceable marker is outputted as the movement speed of the lachrymal fluid of the subject's eye.
摘要翻译： 在眼科测定方法中，向受试者眼睛的泪液施用颗粒状的可追踪标记物，并用照射光照射泪液。 照射的泪液的图像分别在不同时间被电子捕获。 选择拍摄图像中的两个图像，其中两个所选图像中的每一个显示可追踪标记。 指定两个所选图像中的每一个的特征点。 可追踪标记的运动速度是根据两个所选图像中的位置以及与指定两个所选图像之一的特征点的指定时间差来确定两个所选图像中的另一个的特征点来测量的。 可追踪标记的测量移动速度作为受试者眼睛的泪液的移动速度输出。
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公开(公告)号：US08231908B2
公开(公告)日：2012-07-31
申请号：US11989296
申请日：2006-07-19
IPC分类号： A61K35/54
CPC分类号： A61L27/3604 , A01N1/0226 , A61L27/3683 , A61L27/3813 , A61L27/50
摘要： A sheet-shaped composition is provided which has an improved preservability and handling readiness, as well as a high flexibility in use. Amnion with trehalose added thereto is utilized. Addition of trehalose improves the flexibility of the amnion, and prevents basal membrane and stratum compactum from being damaged during lyophilization process.
摘要翻译： 提供了具有改进的保存性和处理准备性以及使用高度灵活性的片状组合物。 利用添加了海藻糖的羊膜。 加入海藻糖可以改善羊膜的柔韧性，并防止在冻干过程中基底膜和地层受到损伤。
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公开(公告)号：US09028065B2
公开(公告)日：2015-05-12
申请号：US13575635
申请日：2011-01-21
IPC分类号： A61B3/10
CPC分类号： A61B3/101
摘要： A ophthalmologic method and apparatus for processing a captured image of a tear film lipid layer on a cornea of a patient's eye to be examined and for classifying types of dry eye of the patient's eye. The captured image of the tear film lipid layer is processed to measure a movement speed of the tear film lipid layer at the time of opening of the patient's eyelid. The captured image of the tear film lipid layer is further processed to measure a time until the tear film lipid layer is broken up after the patient's eyelid has been opened and a break up region is detected. The type of dry eye of the patient's eye is classified based on the two measurement results.
摘要翻译： 一种眼科方法和装置，用于处理待检查的患者眼睛的角膜上的泪膜脂质层的捕获图像，以及用于分类患者眼睛的干眼的类型。 处理泪膜脂质层的捕获图像以测量打开患者眼睑时泪液脂质层的移动速度。 进一步处理泪膜脂质层的拍摄图像，以测量在患者的眼皮已经打开并且检测到分离区域之后眼泪膜脂质层破裂的时间。 根据两个测量结果对患者眼睛的干眼症状进行分类。
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公开(公告)号：US20060263297A1
公开(公告)日：2006-11-23
申请号：US11434657
申请日：2006-05-15
CPC分类号： A61B3/101 , A61B3/10 , A61B3/14 , A61B5/0071 , A61B2576/02 , A61M2210/0612 , G06T7/0014 , G06T2207/30041
摘要： A CCD camera captures an image of the lachrymal fluid layer in a prescribed position of a subject's eye to which a target substance is administered. Images are selected from a plurality of images captured, and the positions of the target substance in the selected images and the capturing times thereof are used to compute the movement speed of the target substance. The computed movement speed of the target substance is then outputted as the movement speed of the lachrymal fluid of the subject's eye. This arrangement allows the movement speed of lachrymal fluid to be reliably measured, assuring quantitative diagnosis even of severe dry eye.
摘要翻译： CCD照相机在目标物质被施用的对象的眼睛的规定位置拍摄泪液层的图像。 从所拍摄的多个图像中选择图像，并且使用所选择的图像中的目标物质的位置及其捕获时间来计算目标物质的移动速度。 然后将目标物质的计算的移动速度作为被检者眼睛的泪液的移动速度输出。 这种安排可以可靠地测量泪液的移动速度，即使严重干眼也能确定定量诊断。
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公开(公告)号：US20090175954A1
公开(公告)日：2009-07-09
申请号：US11989296
申请日：2006-07-19
IPC分类号： A61K35/48
CPC分类号： A61L27/3604 , A01N1/0226 , A61L27/3683 , A61L27/3813 , A61L27/50
摘要： A sheet-shaped composition is provided which has an improved preservability and handling readiness, as well as a high flexibility in use. Amnion with trehalose added thereto is utilized. Addition of trehalose improves the flexibility of the amnion, and prevents basal membrane and stratum compactum from being damaged during lyophilization process.
摘要翻译： 提供了具有改进的保存性和处理准备性以及使用高度灵活性的片状组合物。 利用添加了海藻糖的羊膜。 加入海藻糖可以改善羊膜的柔韧性，并防止在冻干过程中基底膜和地层受到损伤。
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公开(公告)号：US20120300174A1
公开(公告)日：2012-11-29
申请号：US13575635
申请日：2011-01-21
CPC分类号： A61B3/101
摘要： An illumination light is projected onto a tear film lipid layer on a cornea of an eye to be examined, and the reflected light is received and the tear film lipid layer is imaged. The image of the tear film lipid layer that has been captured is processed, and the initial spread speed H′ of the tear film lipid layer at the time the eyelid has been opened is measured. The image of the tear film lipid layer that has been captured is processed, and the time until the tear film lipid layer is broken up after the eyelid has been opened and a dark area T appears is measured. The appearance time of the dark area is plotted on the Y-axis and the initial spread speed H′(0) of the tear film lipid layer is plotted on the X-axis, and the type of dry eye is classified. In such a configuration, since the type of dry eye can be classified and determined, diagnosis and treatment in accordance with the type of dry eye are made possible.
摘要翻译： 将照明光投射到要检查的眼睛的角膜上的泪膜脂质层上，并且接收反射的光，并对泪膜脂质层进行成像。 对已经被捕获的泪膜脂质层的图像进行处理，并且测量在眼睑打开时泪液脂质层的初始铺展速度H'。 处理已经捕获的泪膜脂质层的图像，并且测量在眼睑已经打开并且出现暗区域T之后眼泪膜脂质层破裂的时间。 将暗区的出现时间绘制在Y轴上，将泪膜脂质层的初始铺展速度H'（0）绘制在X轴上，并将干眼的类型分类。 在这样的结构中，由于能够分类确定干眼的种类，因此可以根据干眼的类型进行诊断和处理。
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公开(公告)号：US20120276080A1
公开(公告)日：2012-11-01
申请号：US13544518
申请日：2012-07-09
CPC分类号： A61L27/3604 , A01N1/0226 , A61L27/3683 , A61L27/3813 , A61L27/50
摘要： A sheet-shaped composition is provided which has an improved preservability and handling readiness, as well as a high flexibility in use. Amnion with trehalose added thereto is utilized. Addition of trehalose improves the flexibility of the amnion, and prevents basal membrane and stratum compactum from being damaged during lyophilization process.
摘要翻译： 提供了具有改进的保存性和处理准备性以及使用高度灵活性的片状组合物。 利用添加了海藻糖的羊膜。 加入海藻糖可以改善羊膜的柔韧性，并防止在冻干过程中基底膜和地层受到损伤。
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9.发明授权Methods for corneal endothelial proliferation using bFGF sustained-release gelatin hydrogel particles 有权使用bFGF缓释明胶水凝胶颗粒进行角膜内皮增殖的方法公开(公告)号：US08895508B2
公开(公告)日：2014-11-25
申请号：US13386844
申请日：2009-07-24
申请人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
发明人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
CPC分类号： A61K38/1825 , A61K9/0048 , A61K9/06 , A61K47/42
摘要： The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.
摘要翻译： 本发明的目的在于提供角膜内皮细胞增殖促进剂和与角膜内皮损伤相关的疾病的治疗剂，其被施用于前房。 通过形成bFGF缓释明胶水凝胶颗粒，其中bFGF携带在明胶水凝胶上，以持续的方式释放bFGF。 因此，可以通过将含有bFGF缓释明胶水凝胶颗粒的制剂给予前房来持续加速角膜内皮细胞的增殖，并且可以治疗与角膜内皮损伤有关的疾病。
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公开(公告)号：US20140220102A1
公开(公告)日：2014-08-07
申请号：US14175369
申请日：2014-02-07
IPC分类号： A61L27/36
CPC分类号： A61L27/3604 , A61L27/3641 , A61L27/3666 , A61L27/3683 , A61L27/3813 , A61L27/3839 , A61L2430/16
摘要： It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial cells is formed, the outermost layer is brought into contact with air, thereby inducing differentiation. Thus, an ectocornea-like sheet having an oral mucosal epithelial cell layer on the amnion is obtained.
摘要翻译： 旨在提供适用于需要外耳道移植的眼表疾病的移植材料（即外胚层样片材）。 将口腔粘膜上皮细胞接种到羊膜上，然后在支持细胞共存下培养。 当形成口腔粘膜上皮细胞的分层结构时，最外层与空气接触，从而诱导分化。 因此，获得了在羊膜上具有口腔粘膜上皮细胞层的异齿角膜状片。
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