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    CORNEAL ENDOTHELIAL CELL PROLIFERATION PROMOTER
    2.
    发明申请
    CORNEAL ENDOTHELIAL CELL PROLIFERATION PROMOTER 有权
    角膜内皮细胞增殖促进剂

    公开(公告)号：US20120190621A1

    公开(公告)日：2012-07-26

    申请号：US13386844

    申请日：2009-07-24

    申请人： Yasuhiko Tabata ,  Shigeru Kinoshita ,  Noriko Koizumi ,  Yuji Sakamoto ,  Naoki Okumura ,  Hiroaki Takahashi

    发明人： Yasuhiko Tabata ,  Shigeru Kinoshita ,  Noriko Koizumi ,  Yuji Sakamoto ,  Naoki Okumura ,  Hiroaki Takahashi

    IPC分类号： A61K38/18 ,  A61P27/02

    CPC分类号： A61K38/1825 ,  A61K9/0048 ,  A61K9/06 ,  A61K47/42

    摘要： The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.

    摘要翻译： 本发明的目的在于提供角膜内皮细胞增殖促进剂和与角膜内皮损伤相关的疾病的治疗剂，其被施用于前房。 通过形成bFGF缓释明胶水凝胶颗粒，其中bFGF携带在明胶水凝胶上，以持续的方式释放bFGF。 因此，可以通过将含有bFGF缓释明胶水凝胶颗粒的制剂给予前房来持续加速角膜内皮细胞的增殖，并且可以治疗与角膜内皮损伤有关的疾病。

    CORNEAL ENDOTHELIAL PREPARATION WHICH ENABLES CELLS TO GROW IN VIVO
    4.
    发明申请
    CORNEAL ENDOTHELIAL PREPARATION WHICH ENABLES CELLS TO GROW IN VIVO 审中-公开
    角膜内皮细胞在体内生长的脊髓内皮制剂

    公开(公告)号：US20100233240A1

    公开(公告)日：2010-09-16

    申请号：US12161433

    申请日：2007-01-18

    申请人： Noriko Koizumi ,  Shigeru Kinoshita ,  Yuji Sakamoto

    发明人： Noriko Koizumi ,  Shigeru Kinoshita ,  Yuji Sakamoto

    IPC分类号： A61F2/14 ,  A61K35/44 ,  A61P27/02

    CPC分类号： A61L27/3839 ,  A61L27/24 ,  A61L27/3808 ,  A61L2430/16

    摘要： The present invention provides a graft more suitable for the transplantation of corneal endothelial cells and an application method thereof. Specifically, the present invention provides a corneal endothelial preparation capable of cell proliferation in vivo, which contains a substrate and a corneal endothelial cell layer cultured on the substrate, and a treatment method of a disease selected from the group consisting of bullous keratopathy, corneal edema, corneal leukoma and corneal endothelial inflammation, which includes a step of transplanting the preparation to patients. As the substrate, collagen is used.

    摘要翻译： 本发明提供了更适合于角膜内皮细胞移植的移植物及其应用方法。 具体地说，本发明提供能够在体内进行细胞增殖的角膜内皮制剂，该角膜内皮制剂含有在底物上培养的底物和角膜内皮细胞层，以及选自下组的疾病的治疗方法：大疱性角膜病，角膜水肿 ，角膜白血病和角膜内皮炎症，其中包括将制剂移植到患者中的步骤。 作为底物，使用胶原。

    Ophthalmic measuring method and apparatus
    7.
    发明授权
    Ophthalmic measuring method and apparatus 有权
    眼科测量方法及仪器

    公开(公告)号：US08996097B2

    公开(公告)日：2015-03-31

    申请号：US11434657

    申请日：2006-05-15

    申请人： Norihiko Yokoi ,  Shigeru Kinoshita ,  Takayoshi Suzuki ,  Yutaka Mizukusa ,  Osamu Yamamoto

    发明人： Norihiko Yokoi ,  Shigeru Kinoshita ,  Takayoshi Suzuki ,  Yutaka Mizukusa ,  Osamu Yamamoto

    IPC分类号： A61B6/00 ,  A61B3/14 ,  A61B1/04 ,  A61B3/10 ,  A61B5/00 ,  G06T7/00

    CPC分类号： A61B3/101 ,  A61B3/10 ,  A61B3/14 ,  A61B5/0071 ,  A61B2576/02 ,  A61M2210/0612 ,  G06T7/0014 ,  G06T2207/30041

    摘要： In an ophthalmic measuring method, a traceable marker in particulate form is administered to the lachrymal fluid of a subject's eye, and the lachrymal fluid is irradiated with illuminating light. Images of the illuminated lachrymal fluid are electronically captured respectively at different times. Two images from among the captured images are selected, with each of the two selected images displaying the traceable marker. A characteristic point of each of the two selected images is specified. A movement speed of the traceable marker is measured based on positions thereof in the two selected images and on a time difference from specifying the characteristic point of one of the two selected images to specifying the characteristic point of the other of the two selected images. The measured movement speed of the traceable marker is outputted as the movement speed of the lachrymal fluid of the subject's eye.

    摘要翻译： 在眼科测定方法中，向受试者眼睛的泪液施用颗粒状的可追踪标记物，并用照射光照射泪液。 照射的泪液的图像分别在不同时间被电子捕获。 选择拍摄图像中的两个图像，其中两个所选图像中的每一个显示可追踪标记。 指定两个所选图像中的每一个的特征点。 可追踪标记的运动速度是根据两个所选图像中的位置以及与指定两个所选图像之一的特征点的指定时间差来确定两个所选图像中的另一个的特征点来测量的。 可追踪标记的测量移动速度作为受试者眼睛的泪液的移动速度输出。

    ECTOCORNEA-LIKE SHEET AND METHOD OF CONSTRUCTING THE SAME
    8.
    发明申请
    ECTOCORNEA-LIKE SHEET AND METHOD OF CONSTRUCTING THE SAME 审中-公开
    ECTOCORNEA类似的表格及其构造方法

    公开(公告)号：US20140220102A1

    公开(公告)日：2014-08-07

    申请号：US14175369

    申请日：2014-02-07

    申请人： Takahiro Nakamura ,  Shigeru Kinoshita

    发明人： Takahiro Nakamura ,  Shigeru Kinoshita

    IPC分类号： A61L27/36

    CPC分类号： A61L27/3604 ,  A61L27/3641 ,  A61L27/3666 ,  A61L27/3683 ,  A61L27/3813 ,  A61L27/3839 ,  A61L2430/16

    摘要： It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial cells is formed, the outermost layer is brought into contact with air, thereby inducing differentiation. Thus, an ectocornea-like sheet having an oral mucosal epithelial cell layer on the amnion is obtained.

    摘要翻译： 旨在提供适用于需要外耳道移植的眼表疾病的移植材料（即外胚层样片材）。 将口腔粘膜上皮细胞接种到羊膜上，然后在支持细胞共存下培养。 当形成口腔粘膜上皮细胞的分层结构时，最外层与空气接触，从而诱导分化。 因此，获得了在羊膜上具有口腔粘膜上皮细胞层的异齿角膜状片。

    Nonvolatile semiconductor memory device and method for manufacturing the same
    9.
    发明授权
    Nonvolatile semiconductor memory device and method for manufacturing the same 有权
    非易失性半导体存储器件及其制造方法

    公开(公告)号：US08592885B2

    公开(公告)日：2013-11-26

    申请号：US13365470

    申请日：2012-02-03

    申请人： Shigeru Kinoshita ,  Hisataka Meguro ,  Minori Kajimoto

    发明人： Shigeru Kinoshita ,  Hisataka Meguro ,  Minori Kajimoto

    IPC分类号： H01L29/78 ,  H01L21/336

    CPC分类号： H01L21/28273 ,  H01L29/42336 ,  H01L29/66825

    摘要： According to one embodiment, a nonvolatile semiconductor memory device includes a substrate, a tunneling insulating film, a floating gate, a leak suppression unit, an inter-gate insulating film, and a control gate. The substrate includes silicon. The tunneling insulating film is provided on the substrate. The floating gate is provided on the tunneling insulating film. The leak suppression unit is provided on the floating gate. The inter-gate insulating film is provided on the leak suppression unit. The control gate is provided on the inter-gate insulating film. The dielectric constant of the leak suppression unit is higher than a dielectric constant of the inter-gate insulating film.

    摘要翻译： 根据一个实施例，非易失性半导体存储器件包括衬底，隧道绝缘膜，浮动栅极，泄漏抑制单元，栅极间绝缘膜和控制栅极。 衬底包括硅。 隧道绝缘膜设置在基板上。 浮动栅极设置在隧道绝缘膜上。 泄漏抑制单元设置在浮动栅极上。 栅极间绝缘膜设置在泄漏抑制单元上。 控制栅极设置在栅极间绝缘膜上。 泄漏抑制单元的介电常数高于栅极间绝缘膜的介电常数。