公开(公告)号：US20240279479A1

公开(公告)日：2024-08-22

申请号：US18621997

申请日：2024-03-29

申请人： Singular Genomics Systems, Inc.

发明人： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC分类号： C09B62/36 ,  C09K11/06 ,  G01N33/58

CPC分类号： C09B62/365 ,  C09K11/06 ,  G01N33/582 ,  C09K2211/1018

摘要： Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US20240174709A1

公开(公告)日：2024-05-30

申请号：US18522886

申请日：2023-11-29

申请人： Singular Genomics Systems, Inc.

发明人： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US11958877B2

公开(公告)日：2024-04-16

申请号：US18178802

申请日：2023-03-06

申请人： Singular Genomics Systems, Inc.

发明人： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

摘要： Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230295437A1

公开(公告)日：2023-09-21

申请号：US18130212

申请日：2023-04-03

申请人： Singular Genomics Systems, Inc.

发明人： Ronald Graham ,  Rodrigo Rodriguez

IPC分类号： C09B11/24 ,  C09B69/00 ,  C07F7/08

CPC分类号： C09B11/24 ,  C09B69/008 ,  C07F7/0803 ,  C07F7/083 ,  C07F7/0825 ,  C07H23/00

摘要： Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

公开(公告)号：US20230002436A1

公开(公告)日：2023-01-05

申请号：US17365361

申请日：2021-07-01

申请人： Singular Genomics Systems, Inc.

发明人： Ronald Graham ,  Surya Adhikari ,  Rodrigo Rodriguez ,  Zachary Terranova

IPC分类号： C07H19/10 ,  C07H19/14 ,  C12Q1/6869 ,  C12N9/12

摘要： Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.

公开(公告)号：US20220267603A1

公开(公告)日：2022-08-25

申请号：US17737899

申请日：2022-05-05

申请人： Singular Genomics Systems, Inc.

发明人： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC分类号： C09B62/36 ,  C09K11/06 ,  G01N33/58

摘要： Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US20190352508A1

公开(公告)日：2019-11-21

申请号：US16415700

申请日：2019-05-17

申请人： SINGULAR GENOMICS SYSTEMS, INC.

发明人： Ronald Graham ,  Rodrigo Rodriguez

IPC分类号： C09B11/24 ,  C09B69/00

摘要： Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

公开(公告)号：US11878993B2

公开(公告)日：2024-01-23

申请号：US18295770

申请日：2023-04-04

申请人： Singular Genomics Systems, Inc

发明人： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

摘要： Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US11697736B2

公开(公告)日：2023-07-11

申请号：US16415700

申请日：2019-05-17

申请人： SINGULAR GENOMICS SYSTEMS, INC.

发明人： Ronald Graham ,  Rodrigo Rodriguez

IPC分类号： C09B11/24 ,  C09B69/00 ,  C07F7/08 ,  C07H23/00

CPC分类号： C09B11/24 ,  C07F7/083 ,  C07F7/0803 ,  C07F7/0825 ,  C09B69/008 ,  C07F7/0816 ,  C07H23/00

摘要： Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

公开(公告)号：US20230101281A1

公开(公告)日：2023-03-30

申请号：US17882448

申请日：2022-08-05

申请人： Singular Genomics Systems, Inc.

发明人： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC分类号： C09B62/36 ,  C09K11/06 ,  G01N33/58

摘要： Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).