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1.发明申请公开(公告)号：US20080311102A1
公开(公告)日：2008-12-18
申请号：US10573500
申请日：2004-09-16
IPC分类号： A61K38/43 , C12N15/11 , C12N9/10 , C12N15/00 , C12N5/06 , C12P21/04 , A61P43/00 , C12Q1/68 , C12Q1/02 , G01N33/53 , A61K31/7088
CPC分类号： C07K16/40 , C12N9/1029
摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。
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2.发明申请Diagnostics and therapeutics for diseases associated with neuropeptide ff receptor 1 (npff1) 审中-公开与神经肽ff受体1（npff1）相关疾病的诊断和治疗公开(公告)号：US20060014218A1
公开(公告)日：2006-01-19
申请号：US10508892
申请日：2003-03-14
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/74 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human NPFF1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NPFF1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD和哮喘以及泌尿系统疾病有关的人NPFF1。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD和哮喘以及泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NPFF1的活性的化合物以及包含这些化合物的药物组合物。
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3.发明申请Diagnostics and Therapeutics for Diseases Associated With Glycogen Synthase Kinase 3 Beta (Gsk3b) 审中-公开与糖原合酶激酶3β（Gsk3b）相关的疾病诊断与治疗公开(公告)号：US20080050314A1
公开(公告)日：2008-02-28
申请号：US10590304
申请日：2005-02-12
IPC分类号： A61K48/00 , A61K31/7088 , A61K31/7105 , A61P17/00 , A61P29/00 , A61P5/00 , A61P9/00 , G01N33/00 , G01N33/68 , C12Q1/68 , A61P7/00 , A61P3/00 , A61P25/00 , A61P11/00 , A61K39/395
CPC分类号： G01N33/573 , G01N2333/9121
摘要： The invention provides a human GSK3B which is associated with cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GSK3B as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与心血管疾病，癌症，代谢疾病，血液疾病，炎症，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人类GSK3B。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，代谢疾病，血液疾病，炎症，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制GSK3B活性的化合物以及包含这些化合物的药物组合物。
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4.发明申请Diagnostics and therapeutics for diseases associated with neuropeptide ff receptor 2 (npff2) 审中-公开与神经肽ff受体2（npff2）相关的疾病的诊断和治疗公开(公告)号：US20050244896A1
公开(公告)日：2005-11-03
申请号：US10510018
申请日：2003-03-21
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P25/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68 , G01N33/74 , G01N33/567
CPC分类号： G01N33/74 , C12Q1/6883 , C12Q2600/158 , G01N2500/04
摘要： The invention provides a human NPFF2 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma, and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma, and genito-urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NPFF2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD和哮喘以及泌尿系统疾病有关的人NPFF2。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD和哮喘以及泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NPFF2的活性的化合物以及包含这些化合物的药物组合物。
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5.发明申请Diagnostics and Therapeutics for Diseases Associated with Puromycin Sensitive Aminopeptidase Npepps (Npepps) 审中-公开与嘌呤霉素敏感性氨肽酶Npepps（Npepps）相关的疾病诊断和治疗公开(公告)号：US20070258974A1
公开(公告)日：2007-11-08
申请号：US10588104
申请日：2005-01-22
申请人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts , Ralf Thiele
发明人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts , Ralf Thiele
IPC分类号： A61K31/7052 , A61K31/7105 , A61K38/00 , A61K39/395 , A61P1/00 , A61P11/00 , A61P19/00 , A61P21/00 , A61P29/00 , A61P3/00 , A61P35/00 , A61P5/00 , A61P9/00 , C12Q1/37 , C12Q1/68 , G01N33/573
CPC分类号： C12Q1/37 , G01N33/573
摘要： The invention provides a human NPEPPS which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NPEPPS as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，肌肉骨骼疾病，神经系统疾病，呼吸系统疾病，炎症和泌尿系疾病相关的人NPEPPS。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，肌肉骨骼疾病，神经系统疾病，呼吸系统疾病，炎症和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NPEPPS的活性的化合物以及包含这些化合物的药物组合物。
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6.发明申请Diagnostics and therapeutics for diseases associated with dopamine receptor d4 (drd4) 审中-公开与多巴胺受体d4（drd4）相关疾病的诊断和治疗公开(公告)号：US20060263359A1
公开(公告)日：2006-11-23
申请号：US10548425
申请日：2004-03-06
申请人： Stefan Golz , Ulf Bruggemeier , Holger Summer
发明人： Stefan Golz , Ulf Bruggemeier , Holger Summer
IPC分类号： A61K48/00 , A61K38/54 , G01N33/53 , A61K39/395
CPC分类号： G01N33/9413 , A61K48/00 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The invention provides a human DRD4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DRD4 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与心血管疾病，胃肠和肝脏疾病，血液病症，神经障碍和呼吸系统疾病有关的人类DRD4。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，血液病症，神经障碍和呼吸系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制DRD4的活性的化合物以及包含这些化合物的药物组合物。
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7.发明申请Diagnostics and therapeutics for diseases associated with aryl hydrocarbon receptor (ahr) 审中-公开与芳烃受体相关疾病的诊断和治疗（ahr）公开(公告)号：US20060257405A1
公开(公告)日：2006-11-16
申请号：US10545454
申请日：2004-02-13
申请人： Stefan Golz , Ulf Bruggemeier , Holger Summer
发明人： Stefan Golz , Ulf Bruggemeier , Holger Summer
IPC分类号： A61K48/00 , A61K38/54 , G01N33/567 , A61K39/395
CPC分类号： G01N33/5308
摘要： The invention provides a human AHR which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, respiratory diseases, urological diseases and gastroenterological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, respiratory diseases, urological diseases and gastroenterological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AHR as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与外周和中枢神经系统疾病，心血管疾病，血液病，癌症，炎症，呼吸系统疾病，泌尿科疾病和肠胃疾病相关的人类AHR。 本发明还提供了用于鉴定可用于治疗或预防外周和中枢神经系统疾病，心血管疾病，血液病，癌症，炎症，呼吸系统疾病，泌尿科疾病和胃肠疾病的化合物的化合物。 本发明还涉及结合和/或活化或抑制AHR活性的化合物以及包含这些化合物的药物组合物。
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8.发明申请Diagnostics and therapeutics for diseases associated with vasoactive intestinal peptide receptor 2 (vpac2) 审中-公开与血管活性肠肽受体2（vpac2）相关的疾病的诊断和治疗公开(公告)号：US20060165679A1
公开(公告)日：2006-07-27
申请号：US10513867
申请日：2003-04-25
申请人： Stefan Golz , Ulf Bruggemeier , Holger Summer
发明人： Stefan Golz , Ulf Bruggemeier , Holger Summer
IPC分类号： G01N33/567 , A61K39/395 , A61K48/00 , A61K38/17
CPC分类号： C07K14/723 , A61K38/00 , G01N33/74 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human VPAC2 which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, genitourinary diseases, inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardio-vascular diseases, hematological diseases, genitourinary diseases, inflammation. The invention also features compounds which bind to and/or activate or inhibit the activity of VPAC2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与外周和中枢神经系统疾病，心血管疾病，血液疾病，泌尿生殖疾病，炎症相关的人类VPAC2。 本发明还提供了用于鉴定可用于治疗或预防周围和中枢神经系统疾病，心血管疾病，血液疾病，泌尿生殖疾病，炎症的化合物的测定。 本发明还涉及结合和/或活化或抑制VPAC2的活性的化合物以及包含这些化合物的药物组合物。
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9.发明申请Diagnositics and therapeutics for diseases associated with human g-protein couple receptor 14 (gpr14) 审中-公开与g-蛋白偶联受体14（gpr14）相关疾病的诊断和治疗公开(公告)号：US20060160083A1
公开(公告)日：2006-07-20
申请号：US10531655
申请日：2003-10-15
申请人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts
发明人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/53
CPC分类号： G01N33/74 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human GPR14 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, urological diseases, endocrinological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, urological diseases, endocrinological diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR14 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，泌尿系统疾病，内分泌疾病和癌症有关的人GPR14。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，泌尿系统疾病，内分泌疾病和癌症的化合物的测定。 本发明还涉及结合和/或活化或抑制GPR14活性的化合物以及包含这些化合物的药物组合物。
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10.发明申请Diagnostics and therapeutics for diseases associated with chemokine receptor 11 (ccr11) 审中-公开与趋化因子受体11（ccr11）相关疾病的诊断和治疗公开(公告)号：US20060057143A1
公开(公告)日：2006-03-16
申请号：US10515604
申请日：2003-05-12
申请人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts
发明人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/567 , A61K39/395
CPC分类号： A61K38/195 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6863 , G01N2500/04
摘要： The invention provides a human CCR11 which is associated with the disorders of the peripheral and central nervous system, cardio-vascular diseases, genitourinary diseases, metabolic diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardio-vascular diseases, genitourinary diseases, metabolic diseases and hematological diseases. he invention also features compounds which bind to and/or activate or inhibit the activity of CCR11 as well as pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供了与周围和中枢神经系统疾病，心血管疾病，泌尿生殖疾病，代谢疾病和血液疾病相关的人类CCR11。 本发明还提供了用于鉴定可用于治疗或预防外周和中枢神经系统疾病，心血管疾病，泌尿生殖疾病，代谢疾病和血液疾病的化合物的测定。 他的发明还具有结合和/或活化或抑制CCR11活性的化合物以及包含这些化合物的药物组合物。
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