公开(公告)号：US20140336571A1

公开(公告)日：2014-11-13

申请号：US14280170

申请日：2014-05-16

Applicant: SurModics, Inc.

Inventor： Joram Slager ,  Dale G. Swan ,  Darin DuMez ,  Joseph Ventura ,  Shannon Wadman ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

IPC: A61K47/32 ,  A61K31/436 ,  A61L29/04 ,  A61M25/10 ,  A61L29/08 ,  A61L29/16 ,  A61K31/337 ,  A61K9/14

CPC classification number: A61L29/041 ,  A61K9/0019 ,  A61K31/337 ,  A61K31/436 ,  A61K47/34 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/62 ,  A61L2300/63 ,  A61L2400/06 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  C08L79/02

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.

Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在一个实施方案中，本发明包括药物递送装置，其包括基底; 以及设置在基材上的被覆治疗剂颗粒，所述涂敷的治疗剂颗粒包含颗粒状疏水性治疗剂; 和乙烯基胺聚合物。 制备递送组合物的方法以及试剂盒和使用方法也包括在本文中。

公开(公告)号：US09375519B2

公开(公告)日：2016-06-28

申请号：US13926357

申请日：2013-06-25

Applicant: SurModics, Inc.

Inventor： Kyle Eastenson ,  Aleksey V. Kurdyumov ,  Darin DuMez ,  Klaus Wormuth ,  Nathan A. Lockwood

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61K47/48 ,  C08G69/40 ,  C08G69/44 ,  C08L77/06 ,  C08L77/12 ,  A61L27/18 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06

CPC classification number: A61L31/10 ,  A61K47/6957 ,  A61L27/18 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  C08G69/40 ,  C08G69/44 ,  C08L77/06 ,  C08L77/12

Abstract: Bioerodable poly(etheresteramides) and matrices formed therefrom, such as medical device coatings, are described. The matrices show desirable erosion properties desirable for therapeutic use. The matrices can include a bioactive agent which can be used to treat medical conditions.

Abstract translation: 描述了由生物可侵蚀的聚（醚醚酰胺）和由其形成的基质，例如医疗器械涂层。 基质显示理想的治疗用途所需的侵蚀性质。 基质可包括可用于治疗医疗状况的生物活性剂。

公开(公告)号：US11246963B2

公开(公告)日：2022-02-15

申请号：US14280170

申请日：2014-05-16

Applicant: SurModics, Inc.

Inventor： Joram Slager ,  Dale G. Swan ,  Darin DuMez ,  Joseph Ventura ,  Shannon Wadman ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

IPC: A61K47/32 ,  A61L29/04 ,  A61L29/08 ,  A61K31/337 ,  A61K31/436 ,  A61M25/10 ,  A61L29/16 ,  A61K47/34 ,  A61K9/00

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.

公开(公告)号：US20130344126A1

公开(公告)日：2013-12-26

申请号：US13926357

申请日：2013-06-25

Applicant: SurModics, Inc.

Inventor： Kyle Eastenson ,  Aleksey V. Kurdyumov ,  Darin DuMez ,  Klaus Wormuth

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61K47/6957 ,  A61L27/18 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  C08G69/40 ,  C08G69/44 ,  C08L77/06 ,  C08L77/12

Abstract: Bioerodable poly(etheresteramides) and matrices formed therefrom, such as medical device coatings, are described. The matrices show desirable erosion properties desirable for therapeutic use. The matrices can include a bioactive agent which can be used to treat medical conditions.

Abstract translation: 描述了由生物可侵蚀的聚（醚醚酰胺）和由其形成的基质，例如医疗器械涂层。 基质显示理想的治疗用途所需的侵蚀性质。 基质可包括可用于治疗医疗状况的生物活性剂。