公开(公告)号：US20160176872A1

公开(公告)日：2016-06-23

申请号：US15055108

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

Abstract translation: 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。 或其盐。

公开(公告)号：US20170015655A1

公开(公告)日：2017-01-19

申请号：US15210965

申请日：2016-07-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira KAIEDA ,  Masashi TOYOFUKU ,  Masaki DAINI ,  Hiroshi NARA ,  Masato YOSHIKAWA ,  Naoki ISHII ,  Kousuke HIDAKA

IPC: C07D413/14 ,  C07D417/14 ,  C07D491/08 ,  C07D491/107 ,  C07D413/04 ,  C07D471/04

CPC classification number: C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US20190008836A1

公开(公告)日：2019-01-10

申请号：US15745290

申请日：2016-07-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira KAIEDA ,  Masaki DAINI ,  Hiroshi NARA ,  Masato YOSHIKAWA ,  Naoki ISHII ,  Masashi TOYOFUKU ,  Kousuke HIDAKA

IPC: A61K31/437 ,  A61P25/28 ,  A61K31/4245 ,  A61K31/4035 ,  A61K31/4439

CPC classification number: A61K31/437 ,  A61K31/4035 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61P25/28 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20170144973A1

公开(公告)日：2017-05-25

申请号：US15321609

申请日：2015-06-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26 ,  C07D491/056 ,  C07D491/048 ,  C07F7/08 ,  C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20160176873A1

公开(公告)日：2016-06-23

申请号：US15055156

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

公开(公告)号：US20160176822A1

公开(公告)日：2016-06-23

申请号：US15055197

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

公开(公告)号：US20180263967A1

公开(公告)日：2018-09-20

申请号：US15754934

申请日：2016-08-24

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Akira KAIEDA ,  Naoki ISHII ,  Hiroshi NARA ,  Masato YOSHIKAWA ,  Masaki DAINI

IPC: A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61P29/00

CPC classification number: A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61P29/00 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of inflammatory disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20170253591A1

公开(公告)日：2017-09-07

申请号：US15510225

申请日：2015-09-10

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Takashi IMADA ,  Mitsunori KONO ,  Ayumu SATO ,  Yoshihide TOMATA ,  Atsuko OCHIDA ,  Naoki ISHII ,  Yusuke SASAKI ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D471/04 ,  C07D413/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D239/96 ,  C07D409/14 ,  C07D403/12 ,  C07D401/12 ,  C07D417/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D471/04 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P1/00 ,  A61P11/00 ,  C07D239/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.

公开(公告)号：US20160002169A1

公开(公告)日：2016-01-07

申请号：US14755439

申请日：2015-06-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26 ,  C07D491/056 ,  C07D491/048 ,  C07F7/08 ,  C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

公开(公告)号：US20150299188A1

公开(公告)日：2015-10-22

申请号：US14423310

申请日：2013-08-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masaki OGINO ,  Zenichi IKEDA ,  Jun FUJIMOTO ,  Yusuke OHBA ,  Naoki ISHII ,  Takuya FUJIMOTO ,  Tsuneo ODA ,  Naohiro TAYA ,  Toshiro YAMASHITA ,  Nobuyuki MATSUNAGA

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K9/2018 ,  A61K9/4858 ,  C07D239/80 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/04 ,  C07D417/12 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: Provided is a compound having a superior FLAP inhibitory action and useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, and a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present DESCRIPTION, or a salt thereof.

Abstract translation: 提供具有优异的FLAP抑制作用并可用作动脉硬化等的预防或治疗剂及其盐的化合物。 本发明涉及由下式表示的化合物，其中各符号如本说明书所定义，或其盐。