公开(公告)号：US20160310412A1

公开(公告)日：2016-10-27

申请号：US15104642

申请日：2014-12-15

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yutaka TANOUE ,  Yumiko ISHII ,  Yoshihiro OMACHI ,  Tomoyuki MANOSHIRO

IPC: A61K9/00 ,  A61K39/12 ,  A61K47/40 ,  A61K47/26 ,  A61K47/36 ,  A61K39/08 ,  C12N7/00

CPC classification number: A61K9/0021 ,  A61K39/08 ,  A61K39/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61K2039/5258 ,  A61K2039/54 ,  C12N7/00 ,  C12N2770/16023 ,  C12N2770/16034 ,  Y02A50/386

Abstract: In order to configure a microneedle to be more suitable for administering a vaccine antigen, the present invention is a formulation having a dissolving-type microspike which is used as a microneedle in which a vaccine antigen is stabilized, and which includes a vaccine antigen, an ionic polymer base material, and at least one species selected from the group consisting of a non-reducing sugar, a sugar alcohol, cyclodextrin, and a surfactant.

Abstract translation: 为了将微针配置为更适合于施用疫苗抗原，本发明是具有溶解型小珠的制剂，其用作疫苗抗原稳定化的微针，其包含疫苗抗原， 离子聚合物基材，以及选自非还原糖，糖醇，环糊精和表面活性剂中的至少一种。

公开(公告)号：US20220409734A1

公开(公告)日：2022-12-29

申请号：US17610391

申请日：2020-05-08

Applicant: Yutaka NISHIMOTO ,  Yumiko ISHII ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Dylan Bradley ENGLAND ,  Steve P. LANGSTON ,  Hong Myung LEE ,  Liting MA ,  Zhan SHI ,  Stepan VYSKOCIL ,  Jianing WANG ,  He XU ,  Yutaka NISHIMOTO ,  Yumiko ISHII

IPC: A61K47/68 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00

Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof. Formula (I):

公开(公告)号：US20170014347A1

公开(公告)日：2017-01-19

申请号：US15226612

申请日：2016-08-02

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tetsuya KAWANO ,  Yasushi MIMA ,  Yumiko ISHII

IPC: A61K9/24 ,  A61K9/28 ,  A61K9/20 ,  A61K31/616 ,  A61K31/4439

CPC classification number: A61K9/209 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/5026 ,  A61K9/5078 ,  A61K31/4439 ,  A61K31/616 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly expresses the pharmacological effect of the active ingredient after administration. A dry coated tablet having an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains enteric micro granules containing a proton pump inhibitor.

Abstract translation: 本发明提供了稳定且快速地表达给药后的活性成分的药理作用的活性成分（质子泵抑制剂，乙酰水杨酸）的高稳定性的干燥包衣片剂。 一种具有内芯和外层的干燥包衣片，其中，所述内芯是含有乙酰水杨酸的肠溶片，外层含有含有质子泵抑制剂的肠溶微粒。

公开(公告)号：US20160089338A1

公开(公告)日：2016-03-31

申请号：US14891930

申请日：2014-05-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tetsuya KAWANO ,  Yumiko ISHII

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/616

CPC classification number: A61K9/2081 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/5026 ,  A61K9/5078 ,  A61K9/5084 ,  A61K31/4439 ,  A61K31/616 ,  A61K2300/00

Abstract: Provided is an orally disintegrating tablet which shows high stability of the active ingredients (acetylsalicylic acid and PPI), and expresses the pharmacological effects of the active ingredients stably and rapidly after administration.A multiple-unit type orally disintegrating tablet containing enteric-coated micro granules containing acetylsalicylic acid, enteric-coated micro granules containing a proton pump inhibitor, and an additive, wherein an enteric coating layer of the enteric-coated micro granules containing acetylsalicylic acid contains an aqueous enteric polymer base and a sustained-release base.

Abstract translation: 本发明提供一种表现出高活性成分（乙酰水杨酸和PPI）稳定性的口腔崩解片剂，并且在施用后稳定且快速地表达活性成分的药理作用。 一种含有含有乙酰水杨酸的肠溶包衣微粒，含有质子泵抑制剂的肠溶包衣微粒和添加剂的多单位型口腔崩解片，其中含有乙酰水杨酸的肠溶包衣微粒的肠溶衣层含有 水性肠溶性聚合物基质和缓释碱。