公开(公告)号：US20180008749A1

公开(公告)日：2018-01-11

申请号：US15710507

申请日：2017-09-20

Applicant: The University of Tokyo

Inventor： Atsushi MIYAJIMA ,  Natsuko Inagaki ,  Fuyuki Inagaki ,  Norihiro Kokudo

IPC: A61L31/00 ,  A61L27/36 ,  A61K35/407 ,  A61L27/50 ,  A61L31/14

CPC classification number: A61L31/005 ,  A61K35/407 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/50 ,  A61L31/14 ,  A61L2430/28

Abstract: An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing mesothelial cells; an adhesion preventing method and organ regeneration promoting method each using the cell sheet containing mesothelial cells.

公开(公告)号：US11464597B2

公开(公告)日：2022-10-11

申请号：US16316097

申请日：2017-07-13

Applicant: Mochida Pharmaceutical Co., Ltd. ,  The University of Tokyo

Inventor： Taichi Ito ,  Seiichi Ohta ,  Norihiro Kokudo ,  Mitsuko Isaji ,  Satoshi Shimizu

IPC: A61B90/00 ,  A61L31/14 ,  A61L31/12 ,  A61L31/04

Abstract: [Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded.
[Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.

公开(公告)号：US09506102B2

公开(公告)日：2016-11-29

申请号：US14398202

申请日：2013-05-29

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Yasuteru Urano ,  Masayo Sakabe ,  Tetsuo Nagano ,  Takeaki Ishizawa ,  Suguru Yamashita ,  Norihiro Kokudo ,  Mako Kamiya

IPC: C12Q1/37 ,  C12Q1/48 ,  C09B11/24 ,  C07D493/10 ,  C09K11/06

CPC classification number: C12Q1/37 ,  A61K49/0041 ,  A61K49/006 ,  C07D493/10 ,  C09B11/24 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1088 ,  C12Q1/48

Abstract: A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R2, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group).

公开(公告)号：US20150152469A1

公开(公告)日：2015-06-04

申请号：US14398202

申请日：2013-05-29

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Yasuteru Urano ,  Masayo Sakabe ,  Tetsuo Nagano ,  Takeaki Ishizawa ,  Suguru Yamashita ,  Norihiro Kokudo ,  Mako Kamiya

IPC: C12Q1/37 ,  C12Q1/48

CPC classification number: C12Q1/37 ,  A61K49/0041 ,  A61K49/006 ,  C07D493/10 ,  C09B11/24 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1088 ,  C12Q1/48

Abstract: [Problem]To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe.[Solution]A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R2, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group.)

Abstract translation: [问题]提供能够以高灵敏度快速检测和成像能够在手术期间或手术后存在胰液泄漏的荧光探针，并且还提供使用荧光探针的检测方法和检测试剂盒。 [解决方案]一种用于检测含有下式（I）表示的化合物或其盐的胰液的荧光探针。 （式中，A表示氨基酸残基或N-取代氨基酸残基，A与式中相邻的NH形成酰胺键; R1表示氢原子或1〜4个相同或不同的与 苯环; R2，R3，R4，R5，R6和R7各自独立地表示氢原子，羟基，烷基或卤素原子; R8和R9各自独立地表示氢原子或烷基; X表示C1-C3亚烷基。）

公开(公告)号：US11890145B2

公开(公告)日：2024-02-06

申请号：US17896474

申请日：2022-08-26

Applicant: Mochida Pharmaceutical Co., Ltd. ,  The University of Tokyo

Inventor： Taichi Ito ,  Seiichi Ohta ,  Norihiro Kokudo ,  Mitsuko Isaji ,  Satoshi Shimizu

IPC: A61B90/00 ,  A61L31/14 ,  A61L31/12 ,  A61L31/04

CPC classification number: A61B90/08 ,  A61L31/04 ,  A61L31/12 ,  A61L31/128 ,  A61L31/14 ,  A61L31/146 ,  A61B2090/0816 ,  A61L2420/08

Abstract: An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.