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    FLUORESCENT PROBE
    6.
    发明申请
    FLUORESCENT PROBE 有权
    荧光探针

    公开(公告)号：US20150212073A1

    公开(公告)日：2015-07-30

    申请号：US14378022

    申请日：2013-02-15

    Applicant: THE UNIVERSITY OF TOKYO

    Inventor： Tetsuo Nagano ,  Kenjiro Hanaoka ,  Kazuhisa Hirabayashi ,  Yuko Toki

    IPC: G01N33/52 ,  C07F7/08 ,  C07H17/04

    CPC classification number: G01N33/52 ,  C07F7/0816 ,  C07H17/04 ,  C07H23/00 ,  C12Q1/00

    Abstract: A compound represented by the formula (I) [R1 represents hydrogen atom or a substituent; R2, R3, R6, and R7 represent hydrogen atom, an alkyl group, a halogen atom, or a hydrophilic substituent; R4 and R5 represent an alkyl group or an aryl group; R8 and R9 represent a group cleaved by contact with an object substance for measurement; and X represents silicon atom, germanium atom, or tin atom] or a salt thereof, which is useful as a fluorescent probe that emits red fluorescence by contact with an object substance for measurement.

    Abstract translation: 由式（I）表示的化合物[R 1表示氢原子或取代基; R2，R3，R6和R7表示氢原子，烷基，卤素原子或亲水取代基; R4和R5代表烷基或芳基; R8和R9表示与用于测量的物质接触而断裂的基团; X表示硅原子，锗原子或锡原子）或其盐，其可用作通过与测量对象物质接触而发出红色荧光的荧光探针。

    Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof
    8.
    发明授权
    Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof 有权

    公开(公告)号：US10689394B2

    公开(公告)日：2020-06-23

    申请号：US16306696

    申请日：2017-06-14

    Applicant: The University of Tokyo

    Inventor： Hidenori Ichijo ,  Kengo Homma ,  Naomi Tsuburaya ,  Tetsuo Nagano ,  Takayoshi Okabe ,  Hirotatsu Kojima ,  Manabu Shimonishi ,  Takao Fujisawa ,  Norio Shiibata ,  Tsunehiko Higuchi ,  Seiichi Nakamura ,  Hidehiko Nakagawa ,  Shin-Ichi Ikeda

    IPC: C07D495/04 ,  C07D401/04 ,  A61P21/02 ,  A61K31/4365 ,  A61P21/00

    Abstract: A compound represented by the following formula (1) is provided: wherein X represents a sulfur atom or —CH═CH—; A1 to A4 each independently represent a carbon atom or a nitrogen atom, and at least one of A1 to A4 is a nitrogen atom; R1 represents any one of a 1,2,3,4-tetrahydroquinolyl group (or a 3,4-dihydro-1(2H)-quinolyl group), a 3,4-dihydro-4,4-dimethyl-1(2H)-quinolyl group, a 2,3,4,5-tetrahydro-1H-1-benzazepinyl group, or a substituent represented by the following formula (2): wherein R4 represents a 2,3,4-trifluorophenyl group, a 4-iodophenyl group, a 2,3-difluorophenyl group, a 3,5-difluorophenyl group, a 5-fluoro-2-methylphenyl group, a 3-pentafluorosulfanylphenyl group, a 2,6-dimethylphenyl group, a 4-benzyloxyphenyl group, a 3,5-bis(trifluoromethyl)biphenyl group, a 4-tert-butylphenyl group, a 3-methoxyphenyl group, an unsubstituted or substituted pyridyl group, or an unsubstituted or substituted naphthyl group; R5 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group optionally containing an oxygen atom and/or a double bond, or an unsubstituted or substituted aromatic lower alkyl group; R2 represents a hydrogen atom, a lower alkyl group, a lower acyl group, or an unsubstituted or substituted aromatic lower alkyl group; and R3 represents a hydrogen atom, or R2 and R3 may bind to each other to form a ring.

    THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF
    9.
    发明申请
    THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF 审中-公开

    公开(公告)号：US20190177336A1

    公开(公告)日：2019-06-13

    申请号：US16306696

    申请日：2017-06-14

    Applicant: The University of Tokyo

    Inventor： Hidenori Ichijo ,  Kengo Homma ,  Naomi Tsuburaya ,  Tetsuo Nagano ,  Takayoshi Okabe ,  Hirotatsu Kojima ,  Manabu Shimonishi ,  Takao Fujisawa ,  Norio Shiibata ,  Tsunehiko Higuchi ,  Seiichi Nakamura ,  Hidehiko Nakagawa ,  Shin-Ichi Ikeda

    IPC: C07D495/04 ,  C07D401/04 ,  A61P21/00

    Abstract: It is an object of the present invention to provide a compound inhibiting the binding between ALS-related mutant SOD1 and Derlin-1, a medicament comprising the compound, and a method for treating ALS by administering the medicament to a patient. More specifically, the aforementioned compound is represented by the following formula (1): wherein X represents a sulfur atom or —CH═CH—; A1 to A4 each independently represent a carbon atom or a nitrogen atom, and at least one of A1 to A4 is a nitrogen atom; R1 represents a 1,2,3,4-tetrahydroquinolyl group (or a 3,4-dihydro-1(2H)-quinolyl group), a 3,4-dihydro-4,4-dimethyl-1(2H)-quinolyl group, a 2,3,4,5-tetrahydro-1H-1-benzazepinyl group, or a substituent represented by the following formula (2): wherein R4 represents an unsubstituted or optionally substituted phenyl group, an unsubstituted or optionally substituted pyridyl group, or an unsubstituted or optionally substituted naphthyl group, and R5 represents any one of a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group (optionally containing an oxygen atom and/or a double bond), or an unsubstituted or optionally substituted aromatic lower alkyl group; R2 represents a hydrogen atom, a lower alkyl group, a lower acyl group, or an unsubstituted or optionally substituted aromatic lower alkyl group; and R3 represents a hydrogen atom, or R2 and R3 may bind to each other to form a ring.

    Fluorescent probe
    10.
    发明授权
    Fluorescent probe 有权
    荧光探针

    公开(公告)号：US09250232B2

    公开(公告)日：2016-02-02

    申请号：US14378022

    申请日：2013-02-15

    Applicant: THE UNIVERSITY OF TOKYO

    Inventor： Tetsuo Nagano ,  Kenjiro Hanaoka ,  Kazuhisa Hirabayashi ,  Yuko Toki

    IPC: C07H17/04 ,  G01N33/52 ,  C07F7/08

    CPC classification number: G01N33/52 ,  C07F7/0816 ,  C07H17/04 ,  C07H23/00 ,  C12Q1/00

    Abstract: A compound represented by the formula (I) [R1 represents hydrogen atom or a substituent; R2, R3, R6, and R7 represent hydrogen atom, an alkyl group, a halogen atom, or a hydrophilic substituent; R4 and R5 represent an alkyl group or an aryl group; R8 and R9 represent a group cleaved by contact with an object substance for measurement; and X represents silicon atom, germanium atom, or tin atom] or a salt thereof, which is useful as a fluorescent probe that emits red fluorescence by contact with an object substance for measurement.

    Abstract translation: 由式（I）表示的化合物[R 1表示氢原子或取代基; R2，R3，R6和R7表示氢原子，烷基，卤素原子或亲水取代基; R4和R5代表烷基或芳基; R8和R9表示与用于测量的物质接触而断裂的基团; X表示硅原子，锗原子或锡原子）或其盐，其可用作通过与测量对象物质接触而发出红色荧光的荧光探针。

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