公开(公告)号：US5378475A

公开(公告)日：1995-01-03

申请号：US658695

申请日：1991-02-21

申请人： Thomas J. Smith ,  Paul Ashton ,  Paul A. Pearson

发明人： Thomas J. Smith ,  Paul Ashton ,  Paul A. Pearson

IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50 ,  A61K31/513 ,  A61K31/52 ,  A61K31/522 ,  A61K47/14 ,  A61K47/32 ,  A61P27/02 ,  A61P31/12

CPC分类号： A61F9/0017 ,  A61K9/0051 ,  A61K9/5073 ,  A61K9/284 ,  A61K9/5026 ,  Y10S514/912 ,  Y10S514/914

摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir comprising the effective agent; a first coating layer, which is essentially impermeable to the passage of the effective agent; and a second coating layer, which is permeable to the passage of the effective agent. The first coating layer covers at least a portion of the inner core; however, at least a small portion of the inner core is not coated with the first coating layer. The second coating layer essentially completely covers the first coating layer and the uncoated portion of the inner core.

摘要翻译： 提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。 该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。 该装置包括一个包含有效试剂的内核或储存器; 第一涂层，其对于有效试剂的通过基本上是不可渗透的; 以及第二涂层，其对于有效剂的通过是可渗透的。 第一涂层覆盖内芯的至少一部分; 然而，内芯的至少一小部分没有涂覆第一涂层。 第二涂层基本上完全覆盖内芯的第一涂层和未涂覆部分。

公开(公告)号：US6001386A

公开(公告)日：1999-12-14

申请号：US59448

申请日：1998-04-14

申请人： Paul Ashton ,  Paul A. Pearson

发明人： Paul Ashton ,  Paul A. Pearson

IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/30 ,  A61K31/00 ,  A61K31/192 ,  A61K31/20 ,  A61K31/202 ,  A61K31/23 ,  A61K31/232 ,  A61K38/00 ,  A61K47/30 ,  A61K47/32 ,  A61M31/00 ,  A61P27/00 ,  A61P27/02 ,  A61F2/02 ,  A61F2/14

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61M31/002

摘要： A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed.

摘要翻译： 公开了一种简单且可植入的持续释放药物递送装置，其具有含有有效量的低溶解度剂的内芯，所述有效量的低溶解度试剂被可渗透低溶解度剂的非生物可腐蚀聚合物涂层覆盖。 还公开了一种通过将需要治疗的哺乳动物手术植入这种缓释药物递送装置来治疗哺乳动物以获得期望的局部或全身生理或药理作用的方法。

公开(公告)号：US5773019A

公开(公告)日：1998-06-30

申请号：US534854

申请日：1995-09-27

申请人： Paul Ashton ,  Paul A. Pearson

发明人： Paul Ashton ,  Paul A. Pearson

IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/30 ,  A61K31/00 ,  A61K31/192 ,  A61K31/20 ,  A61K31/202 ,  A61K31/23 ,  A61K31/232 ,  A61K38/00 ,  A61K47/30 ,  A61K47/32 ,  A61M31/00 ,  A61P27/00 ,  A61P27/02 ,  A61F2/02 ,  A61F2/14

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61M31/002

摘要： A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed.

公开(公告)号：US06936270B2

公开(公告)日：2005-08-30

申请号：US10139143

申请日：2002-05-02

申请人： David A. Watson ,  Thomas J. Smith ,  Richard Laporte ,  Jianbing Chen ,  Paul Ashton

发明人： David A. Watson ,  Thomas J. Smith ,  Richard Laporte ,  Jianbing Chen ,  Paul Ashton

IPC分类号： A61B17/56 ,  A61B17/00 ,  A61B17/064 ,  A61B17/16 ,  A61B17/80 ,  A61B17/82 ,  A61B17/86 ,  A61B17/88 ,  A61F2/30 ,  A61K9/00 ,  A61K31/58 ,  A61K38/00 ,  A61L31/16 ,  A61M31/00 ,  A61P19/02 ,  A61K2/02

CPC分类号： A61K9/0024 ,  A61B17/0642 ,  A61B17/1615 ,  A61B17/80 ,  A61B17/82 ,  A61B17/8615 ,  A61B17/8877 ,  A61B17/8886 ,  A61B2017/00004 ,  A61B2017/00429 ,  A61B2017/00955 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61F2/30744 ,  A61F2002/30673 ,  A61F2002/30677 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/416 ,  A61L2300/602 ,  A61M31/002 ,  A61M2210/02

摘要： A therapeutically effective compound is locally administered by associating the compound with a piece of orthopedic hardware that is implanted at an appropriate site within a body. The compound is adapted, such as through a sustained release device, to administer an effective dosage continuously over an extended period of time. The compound may be administered, for example, to a joint of a mammal by intraarticularly implanting a sustained release device to deliver the therapeutically effective compound within a synovial capsule of the joint, such that synovial fluid concentration of the compound is greater than plasma concentration of the compound. A wide range of orthopedic hardware, such as bone screws and staples, may be adapted to use in the systems described herein to provide treatment for a variety of medical conditions.

摘要翻译： 通过将化合物与植入体内适当部位的整形外科硬件相结合来局部施用治疗有效的化合物。 化合物例如通过持续释放装置适于在长时间内连续施用有效剂量。 该化合物可以例如通过关节内植入持续释放装置来将哺乳动物的关节施用于在关节的滑膜内递送治疗有效化合物，使得该化合物的滑液浓度大于 化合物。 诸如骨螺钉和钉钉的各种矫形硬件可适于在本文所述的系统中使用以提供针对各种医疗状况的治疗。

公开(公告)号：US5681964A

公开(公告)日：1997-10-28

申请号：US318160

申请日：1994-10-05

申请人： Paul Ashton ,  Thomas J. Smith ,  Peter G. Glavinos ,  John D. Conklin, Jr. ,  Peter A. Crooks ,  Robert M. Riggs ,  Tadeusz Cynkowski ,  Grazyna Cynkowska

发明人： Paul Ashton ,  Thomas J. Smith ,  Peter G. Glavinos ,  John D. Conklin, Jr. ,  Peter A. Crooks ,  Robert M. Riggs ,  Tadeusz Cynkowski ,  Grazyna Cynkowska

IPC分类号： C07D209/26 ,  C07J5/00 ,  C07J51/00 ,  C07J71/00 ,  C07D209/42

CPC分类号： C07J71/0031 ,  C07D209/26 ,  C07J5/0053 ,  C07J51/00

摘要： Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.

摘要翻译： 描述了含有与聚乙二醇基团连接的活性药物分子的前药及其使用方法。 示例性的可溶性酯前药包含与聚乙二醇（PEG）基团连接的萘普生，曲安奈德，甘哌昔洛韦，紫杉醇，环孢菌素，双脱氧肌苷，三羟基类固醇和氟比洛芬分子。 还描述了含有这些前药的药物组合物，以及使用这些酯治疗疾病状态或症状的方法。

公开(公告)号：US20120016467A1

公开(公告)日：2012-01-19

申请号：US13185664

申请日：2011-07-19

申请人： Jianbing Chen ,  Paul Ashton ,  Thomas J. Smith

发明人： Jianbing Chen ,  Paul Ashton ,  Thomas J. Smith

IPC分类号： A61F2/82 ,  A61K31/58 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/706 ,  A61K31/7076 ,  A61K31/52 ,  A61K9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P33/00 ,  A61P27/06 ,  A61P31/00 ,  A61P31/12 ,  A61K31/513

CPC分类号： A61K9/0024 ,  A61K9/7007 ,  A61K31/513 ,  A61K47/32 ,  A61K47/34 ,  A61K47/55 ,  A61K47/554 ,  A61L17/005 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602

摘要： Disclosed is a sustained release system that includes a polymer and a prodrug having a solubility less than about 1 mg/ml dispersed in the polymer. Advantageously, the polymer is permeable to the prodrug and may be non-release rate limiting with respect to the rate of release of the prodrug from the polymer. This permits improved drug delivery within a body in the vicinity of a surgery via sustained release rate kinetics over a prolonged period of time, while not requiring complicated manufacturing processes.

摘要翻译： 公开了一种持续释放系统，其包括聚合物和分散在聚合物中的溶解度小于约1mg / ml的前药。 有利的是，该聚合物对前药是可渗透的，并且对于前体药物从聚合物的释放速率而言可以是非释放速率的限制。 这允许在不需要复杂的制造过程的情况下通过持续释放速率动力学在延长的时间段内改善在手术附近的身体内的药物递送。

公开(公告)号：US20100080830A1

公开(公告)日：2010-04-01

申请号：US12630246

申请日：2009-12-03

申请人： Paul Ashton ,  Jianbing Chen ,  Thomas J. Smith

发明人： Paul Ashton ,  Jianbing Chen ,  Thomas J. Smith

IPC分类号： A61K9/00 ,  A61P31/12 ,  A61K31/551 ,  A61K31/538 ,  A61K31/496 ,  A61K31/52

CPC分类号： A61K9/0004 ,  A61K9/0024 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/2886 ,  Y02A50/385

摘要： The systems and methods disclosed herein provide sustained delivery of a therapeutic agent for treating a patient, e.g., human, to obtain a desired local or systemic physiological or pharmacological effect. Method includes positioning the sustained released drug delivery system at an area wherein release of the agent is desired and allowing the agent to pass through the device to the desired area of treatment. In some embodiments, the method is for treating or reducing the risk of retroviral or lentiviral infection. In certain embodiments, the method is for preventing or reducing the risk of mother-to-child transmission of HIV, wherein the therapeutic agent is an antiviral agent.

摘要翻译： 本文公开的系统和方法提供用于治疗患者例如人的治疗剂的持续递送以获得期望的局部或全身生理或药理作用。 方法包括将持续释放的药物递送系统定位在需要药剂释放并允许药剂通过该装置至所需治疗区域的区域。 在一些实施方案中，该方法用于治疗或降低逆转录病毒或慢病毒感染的风险。 在某些实施方案中，该方法用于预防或降低HIV母婴传播的风险，其中治疗剂是抗病毒剂。

公开(公告)号：US11026885B2

公开(公告)日：2021-06-08

申请号：US15147203

申请日：2016-05-05

申请人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

发明人： Paul Ashton ,  Leigh T. Canham ,  Christian Barnett

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K38/17 ,  A61K38/28 ,  A61K38/47 ,  A61L27/02 ,  A61L27/54 ,  A61L27/56 ,  C07K16/22 ,  A61K39/395

摘要： This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.

公开(公告)号：US20130101656A1

公开(公告)日：2013-04-25

申请号：US13612076

申请日：2012-09-12

申请人： Dongling Su ,  Paul Ashton ,  Jianbing Chen

发明人： Dongling Su ,  Paul Ashton ,  Jianbing Chen

IPC分类号： A61K47/48

CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/06 ,  A61K31/196 ,  A61K31/382 ,  A61K31/485 ,  A61K31/542 ,  A61K47/55 ,  A61K47/60 ,  A61K47/6903

摘要： The invention provides liquid controlled-release drug delivery compositions which gel upon injection into the body to form, in situ, controlled-release drug implants. The compositions of the invention feature a gel-forming polymer that is insoluble in water, a polyethylene glycol solvent in which the polymer is dissolved, and the drug substance to be delivered.

摘要翻译： 本发明提供了液体控释药物递送组合物，其在注射入体内时凝胶形成原位控制释放的药物植入物。 本发明的组合物的特征在于不溶于水的凝胶形成聚合物，其中溶解聚合物的聚乙二醇溶剂和待递送的药物。

公开(公告)号：US20100119580A1

公开(公告)日：2010-05-13

申请号：US12689956

申请日：2010-01-19

申请人： Hong Guo ,  Paul Ashton

发明人： Hong Guo ,  Paul Ashton

IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K38/02 ,  A61K38/22 ,  A61K31/58 ,  A61K31/7064 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7072

CPC分类号： A61K9/20 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/5089 ,  A61K31/58 ,  Y10T29/49888

摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

摘要翻译： 提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。 该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。 该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。