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    EFFICIENT REDUCTION OF TARGET RNA'S BY SINGLE- AND DOUBLE-STRANDED OLIGOMERIC COMPOUNDS
    3.
    发明申请
    EFFICIENT REDUCTION OF TARGET RNA'S BY SINGLE- AND DOUBLE-STRANDED OLIGOMERIC COMPOUNDS 审中-公开
    单链和双链寡聚化合物有效减少目标RNA

    公开(公告)号：US20100041047A1

    公开(公告)日：2010-02-18

    申请号：US12511437

    申请日：2009-07-29

    申请人： Timothy Vickers ,  Seongjoon Koo ,  C. Frank Bennett ,  Stanley T. Crooke ,  Nicholas M. Dean ,  Brenda F. Baker

    发明人： Timothy Vickers ,  Seongjoon Koo ,  C. Frank Bennett ,  Stanley T. Crooke ,  Nicholas M. Dean ,  Brenda F. Baker

    IPC分类号： C12Q1/68 ,  C07H21/02

    CPC分类号： C12N15/1138 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/53 ,  C12N2310/3525

    摘要： The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds, methods for optimizing target region selection for modulation of RNA expression, methods of optimizing expression modulation of RNA, and the like. The present invention further provides oligomeric compounds, 8-80 nucleobases in length targeted to a target RNA, wherein said oligomeric compound hybridizes to said target RNA and inhibits RNA levels by at least 50% in both single-stranded and double-stranded forms, and multifunctional oligomeric compounds.

    摘要翻译： 本发明尤其提供了选择用于抑制RNA表达的单链寡聚化合物的方法，产生双链寡聚化合物的方法，鉴定优化的双链寡聚化合物的方法，选择优化的单链寡聚化合物的方法 选择优化的双链寡聚化合物的方法，鉴定多功能寡聚化合物的方法，用于优化用于调节RNA表达的靶区选择的方法，优化RNA表达调节的方法等。 本发明进一步提供低聚化合物，长度靶向靶RNA的8-80个核碱基，其中所述寡聚化合物与所述靶RNA杂交并且以单链和双链形式抑制至少50％的RNA水平，以及 多官能寡聚化合物。

    Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
    7.
    发明授权
    Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 失效
    反义寡核苷酸组合物和调节JNK蛋白的方法

    公开(公告)号：US06809193B2

    公开(公告)日：2004-10-26

    申请号：US09774809

    申请日：2001-01-31

    申请人： Robert McKay ,  Nicholas M. Dean ,  Brett P. Monia ,  Pamela Nero ,  William A. Gaarde

    发明人： Robert McKay ,  Nicholas M. Dean ,  Brett P. Monia ,  Pamela Nero ,  William A. Gaarde

    IPC分类号： C12N1585

    CPC分类号： C12N15/1137 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12N2310/3525

    摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.

    摘要翻译： 提供了通过调节编码JunN末端激酶（JNK蛋白）的基因的表达进行治疗的疾病或病症的治疗和诊断的组合物和方法。 本文提供了与编码JNK1，JNK2和JNK3的核酸以及其它JNK蛋白及其特异性同种型特异性杂交的寡核苷酸。 还提供了通过用这种寡核苷酸调节一种或多种JNK蛋白质的表达来治疗患有治疗性干预的疾病或障碍的动物的方法。 还提供了用于治疗和诊断与一种或多种JNK蛋白异常表达相关的疾病或病症的方法。 还提供了用于诱导凋亡和用于治疗与凋亡降低相关的疾病或病症的方法。

    Antisense inhibition of Fas mediated signaling
    9.
    发明授权
    Antisense inhibition of Fas mediated signaling 失效
    反义抑制Fas介导的信号传导

    公开(公告)号：US06204055B1

    公开(公告)日：2001-03-20

    申请号：US09290640

    申请日：1999-04-12

    申请人： Nicholas M. Dean ,  Eric G. Marcusson

    发明人： Nicholas M. Dean ,  Eric G. Marcusson

    IPC分类号： C07H2104

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas, FasL and Fap-1 expression and for treatment of diseases, particularly autoimmune and inflammatory diseases and cancers, associated with overexpression or constitutive activation of Fas, FasL or Fap-1 are provided.

    摘要翻译： 提供化合物，组合物和方法用于抑制Fas介导的信号传导。 组合物包含靶向编码Fas，FasL和Fap-1的核酸的反义化合物。 提供了使用这些反义化合物抑制Fas，FasL和Fap-1表达以及治疗与Fas，FasL或Fap-1的过度表达或组成型激活相关的疾病，特别是自身免疫性和炎性疾病和癌症的方法。

    Oligonucleotides for enhanced modulation of protein kinase C expression
    10.
    发明授权
    Oligonucleotides for enhanced modulation of protein kinase C expression 失效
    用于增强蛋白激酶C表达调节的寡核苷酸

    公开(公告)号：US6117847A

    公开(公告)日：2000-09-12

    申请号：US94714

    申请日：1998-06-15

    申请人： C. Frank Bennett ,  Nicholas M. Dean

    发明人： C. Frank Bennett ,  Nicholas M. Dean

    IPC分类号： A61K38/00 ,  C12N9/12 ,  C12N15/113 ,  C12Q1/68 ,  A61K31/70 ,  C07H21/00

    CPC分类号： C12N15/1137 ,  C12N9/12 ,  C12Q1/6876 ,  C12Q1/6883 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q2600/158

    摘要： Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides are from 5 to 50 nucleotides in length and in one referred embodiment are from 12 to 18 nucleotides in length. The oligonucleotides may be chimeric oligonucleotides and in a preferred embodiment comprise at least one 2'-O-methoxyethyl modification. Pharmaceutical compositions comprising the oligonucleotides of the invention are also provided. Methods of inhibiting protein kinase C expression and methods of treating conditions associated with expression of protein kinase C using oligonucleotides of the invention are disclosed.

    摘要翻译： 提供组合物和方法用于调节蛋白激酶C的表达。提供靶向编码PKC的核酸的寡核苷酸。 寡核苷酸长度为5至50个核苷酸，并且在一个所提及的实施方案中，长度为12至18个核苷酸。 寡核苷酸可以是嵌合寡核苷酸，并且在优选的实施方案中包含至少一个2'-O-甲氧基乙基修饰。 还提供了包含本发明的寡核苷酸的药物组合物。 公开了使用本发明的寡核苷酸抑制蛋白激酶C表达的方法和与蛋白激酶C的表达相关的病症的治疗方法。