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    BIOCIDAL COMPOUNDS AND METHODS FOR USING SAME
    1.
    发明申请
    BIOCIDAL COMPOUNDS AND METHODS FOR USING SAME 审中-公开
    生物化合物及其使用方法

    公开(公告)号：US20150118179A1

    公开(公告)日：2015-04-30

    申请号：US14398926

    申请日：2013-05-16

    Applicant: UNIVERSITY OF MANITOBA

    Inventor： Song Liu

    IPC: A01N43/50 ,  A01N43/647 ,  C07F9/6506 ,  C07D233/72 ,  C07D401/12

    CPC classification number: C07D403/12 ,  A01N33/12 ,  A01N35/02 ,  A01N43/50 ,  A01N43/647 ,  C07D233/72 ,  C07D233/82 ,  C07D401/12 ,  C07D403/14 ,  C07F9/6506 ,  Y10T442/30 ,  Y10T442/40 ,  Y10T442/60 ,  A01N59/00

    Abstract: Biocidally active cationic analogs of N-halamine having two biocidally active groups covalently bonded together in a single molecule and having general Formula (I). Compounds of Formula (I), and precursors thereof, can be in solution form immobilized onto a substrate via physical coating or covalent chemical bonding to functionalize surfaces or added into materials as additives so as to render them biocidal. The biocidal solutions and substrates comprising the compounds or precursors of the present invention can then be used to inactivate pathogenic microorganisms. N-halamine-L-QUAT (I) wherein: the N-halamine may be a cyclic or acyclic N-halamine; L is C1-C6 alkyl, cyclic aromatic or non-aromatic ring, ether, ketone or any other organic linking structures, and QUAT has general formula (II):

    Abstract translation: 具有两个生物活性基团的N-卤代胺的生物活性阳离子类似物在单个分子中共价键合在一起并具有通式（I）。 式（I）化合物及其前体可以是通过物理涂层或共价化学键固定在基底上的溶液形式，以将表面官能化或添加到材料中作为添加剂，以使其具有杀生物活性。 包含本发明化合物或前体的杀生物溶液和底物可用于灭活病原微生物。 N-卤胺-L-QUAT（I）其中：N-卤胺可以是环状或非环状N-卤胺; L是C1-C6烷基，环状芳族或非芳族环，醚，酮或任何其他有机连接结构，QUAT具有通式（II）：

    Development of Lipid Matrix Granules with Incorporation of Polysaccharides for Effective Delivery of an Antimicrobial Essential Oil
    3.
    发明申请
    Development of Lipid Matrix Granules with Incorporation of Polysaccharides for Effective Delivery of an Antimicrobial Essential Oil 有权

    公开(公告)号：US20210236427A1

    公开(公告)日：2021-08-05

    申请号：US17052022

    申请日：2019-05-06

    Applicant: University of Manitoba

    Inventor： Chengbo Yang ,  Song Liu ,  Martin Nyachoti

    IPC: A61K9/16 ,  A61K31/05 ,  A23K20/163 ,  A23K20/158

    Abstract: Antibiotics have long been used at sub-therapeutic levels to control incidences of post-weaning diarrhea and to improve growth performance in pigs. However, the current trend world-wide is to eliminate the use of in-feed antibiotics due to increased public concerns over the spread of antibiotic resistance in bacterial pathogens, which poses a threat to public health. Alternatives to in-feed antibiotics are needed. Thymol essential oil exhibits strong in vitro antibacterial activity; however; direct inclusion of essential oils to pig feeds has limited efficacy due to their high volatility, low stability during feed processing, interactions with other feed components and poor availability in lower gut. To solve these problems, we developed lipid matrix beads using thymol and a fatty acid with incorporation of 2% polysaccharides via a melt-granulation technique. Laurie acid was identified as a suitable carrier for thymol. In vitro release of thymol from lipid matrix granules was determined using simulated salivary fluid (SSF), simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively. The lipid matrix granules with 2% polysaccharides exhibited a slow release rate (%) of essential oil and fatty acid in SSF (21.2±2.3; 36±1.1), SGF (73.7±6.9; 54.8±1.7) and SIF (99.1±1.2; 99.1±0.6), respectively. However, the lipid matrix granules without polysaccharides had quick release (%) of essential oil and fatty acid from the SSF (79.9±11.8; 84.9±9.4), SGF (92.5±3.5; 75.8±5.9) and SIF (93.3±9.4; 93.3±4.6), respectively.

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