Stem cell growth factor-like polypeptides
    3.
    发明授权
    Stem cell growth factor-like polypeptides 失效
    干细胞生长因子样多肽

    公开(公告)号:US06673904B2

    公开(公告)日:2004-01-06

    申请号:US09912935

    申请日:2001-07-24

    IPC分类号: A61K3800

    摘要: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

    摘要翻译: 本发明提供由对应于新型人和小鼠分泌的干细胞生长因子样多肽的这种多核苷酸和突变体或其变体编码的新型多核苷酸和多肽。 这些多核苷酸包括从小鼠骨髓和人胎肝脾,卵巢,成人脑,肺肿瘤,脊髓,子宫颈,卵巢,内皮细胞,脐带,胎盘,淋巴细胞,肺成纤维细胞,胎儿中制备的cDNA文库中分离的核酸序列 大脑和睾丸。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

    Stem cell growth factor-like polypeptides
    5.
    发明授权
    Stem cell growth factor-like polypeptides 失效
    干细胞生长因子样多肽

    公开(公告)号:US07319141B2

    公开(公告)日:2008-01-15

    申请号:US10968674

    申请日:2004-10-19

    IPC分类号: C07K14/475 C07H21/04

    摘要: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

    摘要翻译: 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿皮肤(Hyseq克隆鉴定号15375176),成年脾(Hyseq克隆鉴定号14856094)和人内皮细胞的人睾丸细胞(Hyseq克隆鉴定号2880984和2881695)的cDNA文库中分离的核酸序列 (Hyseq克隆鉴定号13804756,13687487,13804756)。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

    Stem cell growth factor-like polypeptide
    6.
    发明授权
    Stem cell growth factor-like polypeptide 失效
    干细胞生长因子样多肽

    公开(公告)号:US06667391B1

    公开(公告)日:2003-12-23

    申请号:US09764325

    申请日:2001-01-16

    IPC分类号: C07K200

    摘要: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human fetal liver spleen (Hyseq clone identification number 6118092), ovary (Hyseq clone identification number 8375786), adult brain (Hyseq clone identification numbers 701734, 15327638, 15741682, 15954941, 15955015), lung tumor (Hyseq clone identification number 11047146 and 10280328), spinal cord (Hyseq clone identification number 10102150), cervix (Hyseq clone identification numbers 10022437 and 14029194), ovary (Hyseq clone identification number 8319153), endothelial cells (Hyseq clone identification number 13815744), umbilical cord (Hyseq clone identification number 18568149), lymphocyte (Hyseq clone identification number 10257378), lung fibroblast (Hyseq clone identification number 17116257), fetal brain (Hyseq clone identification number 15266959), and testis. Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

    摘要翻译: 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿肝脏脾脏(Hyseq克隆鉴定号6118092),卵巢(Hyseq克隆鉴定号8375786),成年脑(Hyseq克隆鉴定号701734,15327638,15741682,15954941,15955015)分离的核酸序列, 肺癌(Hyseq克隆鉴定号11047146和10280328),脊髓(Hyseq克隆鉴定号10102150),宫颈(Hyseq克隆鉴定号10022437和14029194),卵巢(Hyseq克隆鉴定号8319153),内皮细胞(Hyseq克隆鉴定号13815744 ),脐带(Hyseq克隆鉴定号18568149),淋巴细胞(Hyseq克隆鉴定号10257378),肺成纤维细胞(Hyseq克隆鉴定号17116257),胎儿脑(Hyseq克隆鉴定号码15266959)和睾丸。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。