公开(公告)号：US20060253043A1

公开(公告)日：2006-11-09

申请号：US11124950

申请日：2005-05-09

申请人： Yi Zhang ,  Robert Sweeney

发明人： Yi Zhang ,  Robert Sweeney

IPC分类号： A61B5/04

CPC分类号： A61B5/0472 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7203 ,  A61B2560/0219 ,  A61B2560/0468 ,  A61B2562/046 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3712

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend a patient's posture using cardiac activation sequence information. Devices and methods in accordance with the present invention involve sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the composite cardiac signals, which produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A change in a patient's posture is detected using the cardiac signal vectors. Further embodiments involve sensing the plurality of composite cardiac signals during the patient's predominant cardiac rhythm before detecting the change in the patient's posture. Other embodiments involve discriminating between one of a postural related change and a cardiac rhythm related change using the cardiac signal vectors.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋向于患者的姿势。 根据本发明的装置和方法涉及使用多个可植入电极感测多个复合心脏信号。 使用复合心脏信号进行源分离，其产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用心脏信号矢量检测患者姿势的变化。 另外的实施例涉及在检测患者姿势的变化之前在患者的主要心律期间感测多个复合心脏信号。 其他实施例涉及使用心脏信号矢量区分姿势相关变化和心律相关变化中的一个。

公开(公告)号：US20050288600A1

公开(公告)日：2005-12-29

申请号：US10876008

申请日：2004-06-24

申请人： Yi Zhang ,  Marina Brockway ,  Carlos Ricci ,  Ron Heil ,  Douglas Daum ,  Robert Sweeney ,  Aaron McCabe

发明人： Yi Zhang ,  Marina Brockway ,  Carlos Ricci ,  Ron Heil ,  Douglas Daum ,  Robert Sweeney ,  Aaron McCabe

IPC分类号： A61B5/00 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/042 ,  A61N1/365 ,  A61N1/375 ,  G06K9/62

CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/7207 ,  A61B5/7217 ,  A61N1/3756 ,  G06K9/624

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。 信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。 信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。 如果需要或必要，可以更新所选择的向量。 信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。 分离可以包括主成分分析和/或独立成分分析。 可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

公开(公告)号：US20070043395A1

公开(公告)日：2007-02-22

申请号：US11208923

申请日：2005-08-22

申请人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

发明人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

IPC分类号： A61N1/39

CPC分类号： A61N1/3943

摘要： A nondefibrillating and nonfibrillation-inducing energy is delivered at a first internal thoracic location. A first resulting electrical signal is detected at a second internal thoracic location in or near a target region of a heart. A first defibrillation threshold is estimated using the nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength. The defibrillation threshold represents an energy that when delivered at the first internal thoracic location creates an electric field strength in the target region of the heart that meets or exceeds the target electric field strength.

摘要翻译： 在第一内部胸部位置输送非去纤颤和非诱导性能量。 在心脏的目标区域中或附近的第二内部胸部位置检测到第一个产生的电信号。 使用非去纤颤和非原纤维诱发能量，首先得到的电信号和目标电场强度来估计第一除颤阈值。 除颤阈值表示当在第一内部胸部位置递送时在心脏的目标区域中产生满足或超过目标电场强度的电场强度的能量。

公开(公告)号：US20050053682A1

公开(公告)日：2005-03-10

申请号：US10658194

申请日：2003-09-10

申请人： Yi Zhang ,  Yi Zhang ,  Qingjiang Wu

发明人： Yi Zhang ,  Yi Zhang ,  Qingjiang Wu

IPC分类号： A61K31/365 ,  A61K31/366 ,  A61K31/37 ,  A61K31/4741 ,  A61K36/75 ,  A61K35/78

CPC分类号： A61K36/75

摘要： Methods and uses pertaining to the oral treatment of anorectal conditions in a man or woman in need of such treatment are described, which comprises treatment with an orally effective amount of an extract of Cortex Dictamni in unit dosage form in association with one or more carriers or excipients.

摘要翻译： 描述了与需要这种治疗的男性或女性口腔治疗肛门直肠病症有关的方法和用途，其包括以口服有效量的单位剂量形式的皮质硬脑膜炎提取物与一种或多种载体或 赋形剂。

公开(公告)号：US20230138190A1

公开(公告)日：2023-05-04

申请号：US18091673

申请日：2022-12-30

申请人： Yi Zhang ,  Maruti Gupta Hyde ,  Ziyi LI ,  Vaibhav Singh ,  Christian Maciocco ,  Jaemin Han

发明人： Yi Zhang ,  Maruti Gupta Hyde ,  Ziyi LI ,  Vaibhav Singh ,  Christian Maciocco ,  Jaemin Han

IPC分类号： H04W52/02 ,  H04W36/24

摘要： An apparatus and system of providing energy saving in a network are described. A target node receives, from a source node, a handover request to handover a UE due to at least one of entry of the source node into a power saving state or mobility optimization. In response, the target node transmits a relative energy efficiency value of Bits per Joule and periodic feedback related to a status of the UE for training an AI/ML energy saving model and stops the feedback in response to a stop parameter being met. The stop parameter is a first of: a predicted period of the source node to stay in the power saving state or time for a UE to connect to the target node, a percentage of UEs handed over that enter an idle or inactive state, and a percentage of UEs handed over that are further handed to another node.

公开(公告)号：US20230015807A1

公开(公告)日：2023-01-19

申请号：US17859542

申请日：2022-07-07

申请人： Yi Zhang

发明人： Yi Zhang

IPC分类号： A61N7/02

摘要： The present disclosure relates to transcranial ultrasound systems, devices, and methods which are used for treatment rather than for imaging or medical diagnosis. In accordance with one aspect, a system for applying ultrasound energy includes at least three ultrasound applicators configured to be secured against a head of a person and configured to apply ultrasound energy to the head of the person when activated, and a controller configured to control activation and deactivation of the at least three ultrasound applicators based on a predetermined treatment sequence.

公开(公告)号：USD965873S1

公开(公告)日：2022-10-04

申请号：US29732965

申请日：2020-04-29

申请人： Yi Zhang

设计人： Yi Zhang

公开(公告)号：US11124527B2

公开(公告)日：2021-09-21

申请号：US15579830

申请日：2016-06-03

申请人： Syros Pharmaceuticals, Inc. ,  Christopher Roberts ,  Yi Zhang ,  Francis Beaumier ,  Luce Lépissier

发明人： Jason J. Marineau ,  Peter B. Rahl ,  Kevin Sprott ,  Stephane Ciblat ,  Boubacar Sow ,  Robin Larouche-Gauthier ,  Lauren Berstler ,  Christopher Roberts ,  Yi Zhang ,  Francis Beaumier ,  Luce Lépissier

IPC分类号： C07D513/04 ,  A61P35/00 ,  C07D495/04

摘要： The present invention provides novel compounds of Formulas (I) and (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.

公开(公告)号：US10893824B2

公开(公告)日：2021-01-19

申请号：US13306343

申请日：2011-11-29

申请人： Qi An ,  Yi Zhang

发明人： Qi An ,  Yi Zhang

IPC分类号： A61B5/08 ,  A61B5/053 ,  G16H50/20 ,  A61B7/00 ,  A61B5/0205 ,  A61B7/04 ,  A61B5/024 ,  G06F19/00

摘要： A system and method for automatically analyzing heart failure in a patient, including collecting physiological data from a patient using at least a first sensor and a second sensor to collect two or more sensor measurements, and calculating a first composite value based on at least a first sensor measurement wherein the first composite value is an indication of a likelihood that the patient's heart failure status has changed. If the first composite value is outside of a first specified range, then a second composite value is calculated based on at least a second sensor measurement, wherein the second composite value is an indication of a likelihood that the patient's heart failure status has changed. If the second composite value is outside of a second specified range, then an alert of change in heart failure status is generated.

公开(公告)号：US10469178B2

公开(公告)日：2019-11-05

申请号：US14239834

申请日：2011-08-22

申请人： Yi Zhang ,  Benoist Pierre Sebire ,  Guillaume Decarreau

发明人： Yi Zhang ,  Benoist Pierre Sebire ,  Guillaume Decarreau

IPC分类号： H04B15/00 ,  H04W72/12 ,  H04W24/08 ,  H04W24/10 ,  H04W88/06

摘要： A method including determining if there is in device co-existence interference during operation of the device; and causing information about in device co-existence interference and information about measurements performed by the device to be transmitted to a base station.