公开(公告)号：US20210228647A1

公开(公告)日：2021-07-29

申请号：US17227700

申请日：2021-04-12

申请人： EXOSTEM BIOTEC LTD.

发明人： Chaya BRODIE ,  Shlomit BRODIE

IPC分类号： A61K35/51 ,  A61K35/34 ,  A61K35/28 ,  C12N5/0775 ,  A61P21/00 ,  A61P29/00 ,  C12N15/113

摘要： Isolated cells of a mixed character, possessing a mesenchymal stem cell phenotype and a muscle cell phenotype, as well as extracellular vesicles secreted from same, pharmaceutical compositions comprising same, and methods of treatment comprising administering same, are provided. Further, methods of increasing engraftment of foreign cells by co-administering same are provided.

公开(公告)号：US20240173354A1

公开(公告)日：2024-05-30

申请号：US18442617

申请日：2024-02-15

申请人： EXOSTEM BIOTEC LTD.

发明人： Chaya BRODIE ,  Aharon BRODIE

IPC分类号： A61K35/28 ,  A61K35/50 ,  A61P21/00 ,  A61P43/00

CPC分类号： A61K35/28 ,  A61K35/50 ,  A61P21/00 ,  A61P43/00

摘要： Methods of treating an aging-associated disease, as well as inhibiting aging in a subject, by administering pharmaceutical compositions comprising unmodified and modified MSCs and their exosomes are provided.

公开(公告)号：US10421961B2

公开(公告)日：2019-09-24

申请号：US13377558

申请日：2010-06-10

申请人： Chaya Brodie ,  Shimon Slavin

发明人： Chaya Brodie ,  Shimon Slavin

IPC分类号： C12N15/113 ,  C12N5/0793 ,  A61K31/7105

摘要： Some embodiments of the invention comprise methods, systems, and compositions to selectively induce, whether in vitro or in vivo, the neuronal differentiation of multipotent stromal cells through the application of microRNAs, including but not limited to miRNA-124, miRNA-137 and/or miRNA-9* expression products of those miRNAs, and molecules and compositions containing functional elements of those miRNAs. Some embodiments of the invention also comprise the therapeutic administration and use of such induced cells to treat mammalian injuries and diseases, including but not limited to, nervous system injuries or diseases that may otherwise result in decreased cell or system function.

公开(公告)号：US20220106562A1

公开(公告)日：2022-04-07

申请号：US17503443

申请日：2021-10-18

申请人： EXOSTEM BIOTEC LTD.

发明人： Chaya BRODIE ,  Aharon BRODIE

IPC分类号： C12N5/079 ,  A61K35/30 ,  A61P25/00 ,  A61P25/16

摘要： Cells with a mixed mesenchymal stem cell (MSC) and astrocyte phenotype are provided. Pharmaceutical compositions comprising these cells, extracellular vesicles from these cells as well as methods of production and methods of use are also provided.

公开(公告)号：US09783781B2

公开(公告)日：2017-10-10

申请号：US13817535

申请日：2011-08-14

申请人： Shimon Slavin ,  Chaya Brodie

发明人： Shimon Slavin ,  Chaya Brodie

IPC分类号： C12N15/113 ,  A61K35/12 ,  C12N5/079

CPC分类号： C12N5/0622 ,  A61K35/12 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2330/10 ,  C12N2500/25 ,  C12N2501/39 ,  C12N2501/65 ,  C12N2506/025 ,  C12N2506/1353 ,  C12N2506/1384 ,  C12N2506/1392

摘要： A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.

公开(公告)号：US20210260141A1

公开(公告)日：2021-08-26

申请号：US17261078

申请日：2019-07-18

申请人： EXOSTEM BIOTEC LTD.

发明人： Aharon BRODIE ,  Chaya BRODIE

IPC分类号： A61K35/768 ,  A61K35/28 ,  A61K35/50 ,  A61K31/7105 ,  A61K45/06 ,  A61K38/17

摘要： Compositions comprising at least one of miR that down regulates PD-L1/PD-1, MSCs expressing same, or exosomes from those MSCs are provided. Methods of decreasing PD-L1 expression, PD-1 expression or both and treating PD-L1 positive cancers using same are also provided.

公开(公告)号：US11053476B2

公开(公告)日：2021-07-06

申请号：US16079279

申请日：2017-02-23

申请人： EXOSTEM BIOTEC LTD.

发明人： Chaya Brodie ,  Shlomit Brodie

IPC分类号： C12N5/095 ,  C12N15/113 ,  G01N33/50

摘要： Methods, kits and compositions for generating cancer stem cells are provided.

公开(公告)号：US09803175B2

公开(公告)日：2017-10-31

申请号：US14380165

申请日：2013-02-21

申请人： BrainStem Biotec Ltd. ,  Henry Ford Health System

发明人： Chaya Brodie ,  Shimon Slavin

IPC分类号： C12N15/113 ,  A61K35/12 ,  C12N5/0797 ,  C12N5/0793 ,  A61K35/28 ,  C12Q1/68

CPC分类号： C12N5/0623 ,  A61K35/28 ,  C12N5/0619 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/65 ,  C12N2501/91 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/025 ,  C12N2506/08 ,  C12N2506/1353 ,  C12N2506/1369 ,  C12N2506/1384 ,  C12N2506/1392 ,  C12N2510/00 ,  C12Q1/6876 ,  C12Q2600/158 ,  C12Q2600/178

摘要： A method of generating neural stem cells or motor neurons is disclosed, the method comprising up-regulating a level of at least one exogenous miRNA and/or down-regulating at least one miRNA using an agent which hybridizes to the miRNA in mesenchymal stem cells (MSCs) or down-regulating Related to testis-specific, vespid and pathogenesis protein 1 (RTVP-1).

公开(公告)号：US12053493B2

公开(公告)日：2024-08-06

申请号：US16347016

申请日：2017-11-02

申请人： EXOSTEM BIOTEC LTD.

发明人： Chaya Brodie ,  Shlomit Brodie

IPC分类号： A61K35/50 ,  A61K35/28 ,  A61P3/10 ,  A61P21/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C12N5/00 ,  C12N5/0775

CPC分类号： A61K35/50 ,  A61K35/28 ,  A61P3/10 ,  A61P21/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C12N5/0018 ,  C12N5/0668

摘要： The present invention provides pharmaceutical compositions comprising a mesenchymal stromal cell (MSC) population, extracellular vesicles secreted from said MSC population, and a combination thereof, and methods of use thereof in treatment of a disease or disorder.

公开(公告)号：US20230183809A1

公开(公告)日：2023-06-15

申请号：US17920858

申请日：2021-04-22

申请人： EXOSTEM BIOTEC LTD.

发明人： Aharon BRODIE

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention provides methods of detecting a cellular state in a subject, comprising providing a sample from the subject comprising extracellular vesicles (EVs), isolating a population of EVs originating from a tissue or cell type from the sample, and determining in the population of EVs the presence of at least one factor indicative of the cellular state, wherein the presence of the at least one factor indicates the cellular state is present in the tissue or cell type, thereby detecting a cellular state in a subject.