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公开(公告)号：US20240054761A1
公开(公告)日：2024-02-15
申请号：US17766439
申请日：2020-10-02
IPC分类号： G06V10/764 , G06V10/20 , G06T7/11 , G06T11/60 , G06V10/82
CPC分类号： G06V10/764 , G06V10/255 , G06T7/11 , G06T11/60 , G06V10/82 , G06T2207/10016 , G06T2210/22 , G06T2207/20084 , G06T2207/10056 , G06T2207/30072 , G06V2201/03
摘要： The present disclosure provides a system and method for image analysis which utilize trained neural networks. The system and method are useful for generation and/or analysis of a variety of objects, such as biological cells to determine clonality.
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公开(公告)号：US20210290824A1
公开(公告)日：2021-09-23
申请号：US16324459
申请日：2017-08-10
摘要： The present invention provides a method for functionalizing a medical implant surface to promote osseointegration upon implantation in bone tissue.
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公开(公告)号：US10513709B2
公开(公告)日：2019-12-24
申请号：US15895976
申请日：2018-02-13
发明人： Dietrich M. Egli
IPC分类号： C12N15/00 , C12N15/877 , C12N5/0735 , C12N5/075
摘要： The present invention provides methods for making reconstructed diploid human oocytes comprising the diploid genome of a human somatic cell, and also methods for making human nuclear transfer embryos, human embryonic stem cells, and human differentiated cells therefrom. The present invention also provides reconstructed human oocytes, human nuclear transfer embryos, human embryonic stem cells, and differentiated cells made using such methods, as well as compositions and kits useful in performing such methods.
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公开(公告)号：US10301592B2
公开(公告)日：2019-05-28
申请号：US15313079
申请日：2015-05-22
摘要： Described is the efficient and robust generation of oligodendrocyte progenitor cells (OPCs) and oligodendrocytes from pluripotent stem cells (PSCs). The protocols provided recapitulate the major steps of oligodendrocyte differentiation, from neural stem cells to OLIG2+progenitors, and then to 04+ OPCs, in a significantly shorter time than the 120-150 days required by previous protocols. Furthermore, 04+ OPCs are able to differentiate into MBP+mature oligodendrocytes in vitro, and to myelinate axons in vivo when injected into immuno-compromised Shiverer mice, providing proof of concept that transplantation of PSC-derived cells for remyelination is technically feasible.
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公开(公告)号：US09434960B2
公开(公告)日：2016-09-06
申请号：US14098424
申请日：2013-12-05
发明人： Dietrich M. Egli
IPC分类号： A01K67/027 , C12N15/00 , C12N15/873 , C12N5/075 , C12N5/16 , C12N15/877
CPC分类号： C12N15/873 , A61K35/54 , C12N5/0609 , C12N5/16 , C12N7/00 , C12N15/8775 , C12N15/8776 , C12N2517/04 , C12N2517/10 , C12N2760/18832
摘要： The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.
摘要翻译： 本发明提供了具有衍生自来自不同受试者的第二卵母细胞的第一卵母细胞和细胞质的核基因组的修饰的卵母细胞，以及用于制备和使用这些修饰的卵母细胞的方法。 本发明的方法和组合物可用于多种设置，包括但不限于体外受精（“IVF”）程序。
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公开(公告)号：US20240191203A1
公开(公告)日：2024-06-13
申请号：US18344024
申请日：2023-06-29
发明人： Scott Noggle , Kevin C. Eggan , Stephen Chang , Susan L. Solomon
CPC分类号： C12N5/0696 , C12M23/04 , C12M35/02 , C12M35/08 , C12M47/04
摘要： The invention provides an automated system for producing induced pluripotent stem cells (iPSCs) from adult somatic cells. Further, the system is used for producing differentiated adult cells from stem cells.
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公开(公告)号：US20230419480A1
公开(公告)日：2023-12-28
申请号：US17998724
申请日：2021-05-14
CPC分类号： G06T7/0012 , G16H50/20 , G16H50/70 , G16H10/40 , G06T2207/10056 , G06T2207/20081 , G06T2207/30024
摘要： The present disclosure provides automated methods and systems for implementing an aging analysis pipeline involving the training and deployment of a predictive model for predicting cellular ages of cells. Such a predictive model distinguishes between morphological cellular phenotypes e.g., morphological cellular phenotypes elucidated using Cell Paint, exhibited by cells of different ages. The predictive model is further useful for developing new cellular aging assays that include biomarkers that heavily contribute towards predictions of the predictive model. Furthermore, the predictive model is useful for screening drug candidates for their ability to alter or suppress age related phenotypes.
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公开(公告)号：US20230144965A1
公开(公告)日：2023-05-11
申请号：US17987073
申请日：2022-11-15
发明人： Scott Noggle , Stephen Chang
CPC分类号： C12M47/04 , B01L3/5027 , F16K99/0003 , G01N15/02 , F16K2099/0086 , G01N2015/0065
摘要： This invention concerns an integrated microfluidic system that utilizes microfluidic chip technology to receive a patient sample including cells, expand the cells, reprogram the expanded cells and then store the reprogrammed cells in a microfluidic chip. These microfluidic chips with stored reprogrammed cells may then be used in scenarios of genetic differentiation into specific cell types. Overall this system and workflow is suitable as a hospital based device that will allow the generation of iPSCs from every patient for downstream diagnostic or therapeutic use.
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9.发明申请公开(公告)号：US20220251504A1
公开(公告)日：2022-08-11
申请号：US17614916
申请日：2020-05-29
发明人： Valentina Fossati , Matthew Zimmer , Lilianne Barbar , Tanya Jain
摘要： Described is the efficient and robust generation and isolation of functional astrocytes from pluripotent stem cells (PSCs). The methodology provided recapitulate the major steps of oligodendrocyte differentiation into mixed cell populations and subsequent isolation of astrocytes from the mixed cell populations.
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