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    High refractive index triazine monomer
    4.
    发明申请
    High refractive index triazine monomer 失效
    高折射率三嗪单体

    公开(公告)号：US20020158352A1

    公开(公告)日：2002-10-31

    申请号：US09925479

    申请日：2001-08-10

    Inventor： Eun Kyoung Kim

    IPC: C07D201/00

    CPC classification number: C07D251/10 ,  C07D251/46

    Abstract: The present invention relates to a triazine type monomer, and more particularly, to a 1,3,5-triazine type monomer characterized by having at least one amine group and at least two sulfur atoms, which can be used in manufacturing transparent optical resins having excellent refractive index, surface hardness and absorbance as well as an improved workability and the ability to control a wide range of refractive index according to the change in composition by the monomer itself at room temperature or by polymerizing the monomer with a comonomer in the presence of an organic solvent or an initiator.

    Abstract translation: 本发明涉及三嗪型单体，更具体地说，涉及一种具有至少一个胺基和至少两个硫原子的1,3,5-三嗪型单体，其可用于制造具有 优异的折射率，表面硬度和吸光度以及改进的可加工性以及根据单体本身在室温下的组成变化来控制宽范围的折射率的能力，或通过在共聚单体存在下将共聚单体聚合 有机溶剂或引发剂。

    Process for producing cyclic N-hydroxy imide compounds
    6.
    发明授权
    Process for producing cyclic N-hydroxy imide compounds 有权
    环状N-羟基酰亚胺化合物的制备方法

    公开(公告)号：US08217182B2

    公开(公告)日：2012-07-10

    申请号：US12510393

    申请日：2009-07-28

    Applicant: Yasuteru Kajikawa

    Inventor： Yasuteru Kajikawa

    IPC: A61K31/395 ,  A61K31/35 ,  C07D201/00 ,  C07D307/02 ,  C07D309/02

    CPC classification number: C07D309/32

    Abstract: A cyclic polycarboxylic acid anhydride, a polycarboxylic acid, or a mixture of them is allowed to react with hydroxylamine or a salt thereof in an organic solvent under dewatering conditions to yield a corresponding cyclic N-hydroxyimide compound. The cyclic polycarboxylic acid anhydride can be, for example, succinic anhydride or glutaric anhydride. The polycarboxylic acid can be, for example, succinic acid, glutaric acid, or adipic acid. In this process, the reaction is preferably carried out using an organic solvent capable of undergoing azeotropy with water as all or part of a reaction solvent while removing water from the reaction system by azeotropy with the organic solvent. This process produces a cyclic N-hydroxyimide compound in a good yield from any of a cyclic polycarboxylic acid anhydride and a polycarboxylic acid.

    Abstract translation: 在脱水条件下，使环状多元羧酸酐，多元羧酸或它们的混合物与羟胺或其盐在有机溶剂中反应，得到相应的环状N-羟基酰亚胺化合物。 环状多元羧酸酐可以是例如琥珀酸酐或戊二酸酐。 多元羧酸可以是例如琥珀酸，戊二酸或己二酸。 在该方法中，优选使用能够与水共沸的有机溶剂作为全部或部分反应溶剂进行反应，同时通过与有机溶剂共沸除去反应体系中的水分。 该方法以环状多元羧酸酐和多元羧酸中的任何一种产生良好的收率的环状N-羟基酰亚胺化合物。

    NOVEL ANTIMICROBIAL ACTIVITY OF GEMFIBROZIL
    9.
    发明申请
    NOVEL ANTIMICROBIAL ACTIVITY OF GEMFIBROZIL 失效
    GEMFIBROZIL的新型抗微生物活性

    公开(公告)号：US20030100042A1

    公开(公告)日：2003-05-29

    申请号：US08608712

    申请日：1996-02-29

    Inventor： CHRISTINA KABBASH ,  HOWARD A. SHUMAN ,  SAMUEL C. SILVERSTEIN ,  PHYLLIS DELLA-LATTA

    IPC: C12N009/00 ,  C12Q001/18 ,  C12Q001/02 ,  C12Q001/00 ,  C12Q001/26 ,  C07D201/00

    CPC classification number: A61K31/192 ,  Y02A50/478 ,  Y02A50/481

    Abstract: The present invention provides for a method for inhibiting growth of a bacterium which consists essentially of contacting the bacterium with a compound having the structure: 1 wherein each of R1, R2, R3, R4, R5 and R6 may be independently H, F, Cl, Br, I, nullOH, nullOR7, nullCN, nullCOR7, nullSR7, nullN(R7)2, nullNR7COR8, nullNO2, null(CH2)pOR7, null(CH2)pX(R7)2, null(CH2)pXR7COR8, a straight chain or branched, substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, or heteroaryl; wherein a linkage to the benzene ring may alternatively be nullNnull, nullSnull, nullOnull or nullCnull; wherein R7 or R8 may be independently H, F, Cl, Br, I, nullOH, nullCN, nullCOH, nullSH2, nullNH2, nullNHCOOH, null(CH2)pOH, null(CH2)pX(CH2), null(CH2)pXCOH, a straight chain or branched, substituted or unsubstituted C1-C10 alkyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, or heteroaryl; wherein A may be nullN2null, nullNHnull, nullCnullCnullCH2null, nullCnullCnullC2HOHnull, nullCnullCnullCH2null, nullCH2nullCH2nullOnull, nullCH2nullCH2nullCH2nullOnull, nullSnull, nullS(nullO)2null, nullCnullOnull, nullCnullOnullOnull, nullNHnullCnullOnull, nullCnullOnullNHnull; and wherein Q, p, N and X may independently be an integer from 1 to 10, or if Q is 1 A may be a (C1-C10)-alkyl chain, (C1-C10)-alkenyl chain or (C1-C10)-alkynyl chain which can optionally be interrupted 1 to 3 times by nullOnull or nullSnull or nullNnull; or a pharmaceutically acceptable salt or ester thereof, which compound is present in a concentration effective to inhibit growth of the bacterium. A may be an (C1-C10)-alkylene chain, (C1-C10)-alkyl chain, or (C1-C10)-alkynyl chain which is branched or unbranched, substituted or unsubstituted and can optionally be interrupted 1 to 3 times by nullOnull or nullSnull or nullNnull.

    Abstract translation: 本发明提供了一种抑制细菌生长的方法，其基本上使细菌与具有以下结构的化合物接触：其中R 1，R 2，R 3，R 4，R 5和R 6各自独立地为H，F，Cl， Br，I，-OH，-OR7，-CN，-COR7，-SR7，-N（R7）2，-NR7COR8，-NO2， - （CH2）pOR7， - （CH2）pX（R7）2， - （ CH2）pXR7COR8，直链或支链的取代或未取代的C1-C10烷基，C2-C10烯基，C2-C10炔基，C3-C10环烷基，C3-C10环烯基，硫代烷基，亚甲基硫代烷基，酰基，苯基，取代的苯基， 或杂芳基; 其中与苯环的连接可以是-N，-S-，-O-或-C-; 其中R 7或R 8可以独立地是H，F，Cl，Br，I，-OH，-CN，-COH，-SH 2，-NH 2，-NHCOOH， - （CH 2）p OH， - （CH 2）p X（CH 2） - （CH 2）pXCOH，直链或支链的取代或未取代的C 1 -C 10烷基，硫代烷基，亚甲硫基烷基，酰基，苯基，取代的苯基或杂芳基; 其中A可以是-N 2 - ， - NH - ， - C = C = CH 2 - ， - C = C-C 2 HOH - ， - C = C-CH 2 - ， - CH 2 -CH 2 -O - ， - CH 2 -CH 2 -CH -O - ， - S - ， - S（= O）2 - ， - C = O-，

    Method and composition for sterilizing surgical instruments
    10.
    发明申请
    Method and composition for sterilizing surgical instruments 审中-公开
    消毒手术器械的方法和组成

    公开(公告)号：US20020192731A1

    公开(公告)日：2002-12-19

    申请号：US10007613

    申请日：2001-10-26

    Inventor： Jason C. H. Shih

    IPC: G01N033/53 ,  G01N033/537 ,  G01N033/543 ,  C11D001/00 ,  G01N033/569 ,  C12Q001/02 ,  C12Q001/22 ,  C12Q001/18 ,  C12Q001/04 ,  C12N015/09 ,  C07F001/00 ,  C07K001/00 ,  C07H001/00 ,  C07J001/00 ,  C07C001/00 ,  C07D201/00

    CPC classification number: A61L2/0023 ,  A61L2/0082 ,  A61L2/04 ,  A61L2/16

    Abstract: A method and composition for sterilizing articles that are contaminated with infectious prion protein, such as surgical instruments, kitchen utensils, laboratory tools, etc., comprising the steps of: (a) heating the articles to be treated at a moderate temperature well below the incineration temperature of said infectious prion protein, wherein said moderate temperature is sufficient to enhance the proteolytic susceptibility of infective prion protein associated with said articles; and (b) exposing the heated articles to a proteolytic enzyme that is effective for at least partial reduction of the infective protein prion associated with said articles under said moderate temperature.

    Abstract translation: 用于对被感染性朊病毒蛋白污染的制品进行灭菌的方法和组合物，例如手术器械，厨房用具，实验室工具等，其包括以下步骤：（a）在远低于 所述感染性朊病毒蛋白的焚烧温度，其中所述中等温度足以增强与所述制品相关的感染性朊蛋白的蛋白水解易感性; 和（b）将加热的物品暴露于在所述中等温度下有效用于至少部分还原与所述制品相关的感染性蛋白质朊病毒的蛋白水解酶。

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