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    BIOMARKER PROXY TESTS AND METHODS FOR STANDARD BLOOD CHEMISTRY TESTS
    2.
    发明申请
    BIOMARKER PROXY TESTS AND METHODS FOR STANDARD BLOOD CHEMISTRY TESTS 有权

    公开(公告)号：US20240417789A1

    公开(公告)日：2024-12-19

    申请号：US18799929

    申请日：2024-08-09

    Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE

    Inventor： Matthew Huentelman ,  Timothy McDaniel ,  Marcus Naymik

    IPC: C12Q1/6869 ,  C12Q1/6881

    Abstract: The present disclosure relates to alternative methods of conducting standard blood chemistry tests, the methods typically comprising: extracting an RNA from a blood sample, determining a mRNA level of a predictive gene in the blood sample, and converting the mRNA level of the predictive gene into the blood test result of the target blood component. The present disclosure also relates to blood test for performing the proxy methods. The blood test includes a plasmid with at least an exon of a predictive gene, a reagent for detecting a mRNA level of the predictive gene, and a reagent for detecting a mRNA level of a housekeeping gene.

    HLA GENE AMPLIFICATION PRIMER, KIT, SEQUENCING LIBRARY ESTABLISHMENT METHOD, AND SEQUENCING METHOD
    3.
    发明申请
    HLA GENE AMPLIFICATION PRIMER, KIT, SEQUENCING LIBRARY ESTABLISHMENT METHOD, AND SEQUENCING METHOD 有权

    公开(公告)号：US20240410000A1

    公开(公告)日：2024-12-12

    申请号：US18701537

    申请日：2022-04-25

    Applicant: XI'AN HAORUI GENE TECHNOLOGIES LTD

    Inventor： Bo WANG ,  Runjun HE ,  Chaoqiong CHEN ,  Long YANG ,  Yue ZHANG

    IPC: C12Q1/6881 ,  C12N15/10

    Abstract: Provided is an HLA gene amplification primer, comprising primers of any one or more groups of the following nine primer groups: a first primer group: SEQ ID NO: 1 and SEQ ID NO: 2; a second primer group: SEQ ID NO: 3 and SEQ ID NO: 4; a third primer group: SEQ ID NO: 5 and SEQ ID NO: 6; a fourth primer group: SEQ ID NO: 7 and SEQ ID NO: 8; a fifth primer group: SEQ ID NO: 9 and SEQ ID NO: 10; a sixth primer group: SEQ ID NO: 11 and SEQ ID NO: 12; a seventh primer group: SEQ ID NO: 12 and SEQ ID NO: 13; an eighth primer group: SEQ ID NO: 14 and SEQ ID NO: 15; and a ninth primer group: SEQ ID NO: 16, SEQ ID NO: 17, and SEQ ID NO: 18. Also provided is a kit for HLA gene sequencing, which comprises the described HLA gene amplification primer; provided is a gene sequencing library construction method based on the described HLA gene amplification primer and an HLA gene sequencing method based on the HLA gene sequencing library construction method.

    DEVICES, METHODS AND KITS FOR BIOLOGICAL SAMPLE CAPTURE AND PROCESSING
    7.
    发明公开
    DEVICES, METHODS AND KITS FOR BIOLOGICAL SAMPLE CAPTURE AND PROCESSING 审中-公开

    公开(公告)号：US20240301491A1

    公开(公告)日：2024-09-12

    申请号：US18180400

    申请日：2023-03-08

    Applicant: VosBio, Inc.

    Inventor： Douglas T. GJERDE ,  Daniel Robert BOLLINGER

    IPC: C12Q1/6881 ,  A61B5/097 ,  C12Q1/6844

    CPC classification number: C12Q1/6881 ,  A61B5/097 ,  C12Q1/6844

    Abstract: Breath liquid particles and vapor are captured in a device presenting a surface and chamber space that condenses or freezes the vapor and aerosol particulates. One or more breaths are exhaled through the device. Capture can be performed on the freezing surface immobilizing water upon contact. The chamber space within the device may freeze or condense liquid breath particles and vapor to collect them. After collection, the liquid is gathered and collected either by draining, scraping, pushing, or centrifugal force. The liquid may be collected and combined with a sample preparation reagent such as a virus lysing reagent, an internal standard, etc. After collection, the sample is separated into a plurality of independently analyzable units for detection and quantification of a target. Analysis may be performed by PCR, qPCR RT-PCR, RT-qPCR, LAMP, RPA or any nucleic acid detection method, lateral antigen mass spectrometry, spectrophotometry or any analytical tool or method. Nucleic acid amplification reagents may contain a lysing reagent such as acetonitrile.

    USE OF GENETIC AND EPIGENETIC MARKERS TO DETECT CELL DEATH
    10.
    发明公开
    USE OF GENETIC AND EPIGENETIC MARKERS TO DETECT CELL DEATH 审中-公开

    公开(公告)号：US20240279720A1

    公开(公告)日：2024-08-22

    申请号：US18291091

    申请日：2022-07-25

    Applicant: Georgetown University

    Inventor： Anton Wellstein ,  Megan E. McNamara ,  Alexander H.K. Kroemer

    IPC: C12Q1/6827 ,  A61K45/06 ,  C12Q1/6881

    CPC classification number: C12Q1/6827 ,  A61K45/06 ,  C12Q1/6881 ,  C12Q2600/154 ,  C12Q2600/156

    Abstract: A method of detecting donor cell death in a subject receiving foreign biological material from a donor. The method comprises sequencing cfDNA in a biospecimen from the subject; determining cellular origin of the cfDNA by identifying methylation patterns in the sequence of the cfDNA and comparing the methylation patterns in the sequence of the cfDNA to known methylation patterns associated with different cell types; and determining source origin of the cfDNA by genotyping the cfDNA and identifying whether the cfDNA originates from the foreign biological material or from the subject. Cell death is detected when the cfDNA has both a cellular origin of the type of foreign biological material that was received from the donor, and a source origin of the donor.

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