公开(公告)号：US20240294464A1

公开(公告)日：2024-09-05

申请号：US18642526

申请日：2024-04-22

申请人： Genentech, Inc.

发明人： Nicholas WONG ,  Francis GOSSELIN

IPC分类号： C07C229/34 ,  A61K51/08 ,  A61K51/10 ,  C07C57/15 ,  C07C227/18 ,  C07C227/40 ,  C07D239/557 ,  C07D319/12 ,  C07F5/06

CPC分类号： C07C229/34 ,  A61K51/088 ,  A61K51/1096 ,  C07C57/15 ,  C07C227/18 ,  C07C227/40 ,  C07D239/557 ,  C07D319/12 ,  C07F5/069 ,  C07B2200/05

摘要： Improved methods of synthesis of a restrained complexing agent are described herein. Compounds, including salts and solvates thereof, and compositions relevant to the improved methods are also described.

公开(公告)号：US20230391715A1

公开(公告)日：2023-12-07

申请号：US18032603

申请日：2021-10-19

申请人： Procos S.P.A.

发明人： Davide Gornati ,  Fabio Morana ,  Jacopo Roletto ,  Paolo Paissoni

IPC分类号： C07C269/04 ,  C07C227/40 ,  C07C213/08 ,  C07C213/10 ,  C07C229/36 ,  C07C59/50 ,  C07C227/36

CPC分类号： C07C269/04 ,  C07C227/40 ,  C07C213/08 ,  C07C213/10 ,  C07C229/36 ,  C07C59/50 ,  C07C227/36 ,  C07B2200/07

摘要： The present invention concerns a novel process for preparing solriamfetol hydrochloride.

公开(公告)号：US11247964B2

公开(公告)日：2022-02-15

申请号：US15131133

申请日：2016-04-18

申请人： RRIP, LLC

发明人： Mohan Prasad A. Dasari ,  Abdullah A. Mahfuz ,  Shashank Ravi ,  Hugh Tallant Warren

IPC分类号： C07C227/40 ,  C07C227/28 ,  C07C213/08 ,  C07C213/10 ,  C07C29/09 ,  C07C29/76 ,  A23K20/174 ,  C11B13/02 ,  A23K10/14 ,  A23K20/158 ,  A23K20/26 ,  C11B13/00 ,  A23J7/00 ,  C12P7/64 ,  C11B11/00 ,  C07C227/38 ,  C11B1/02

摘要： The present invention provides methods of processing lipid materials such as soapstock, wet gums and dry gums. Enzymes are utilized to catalyze hydrolysis of the lipids materials to recover fatty acids. Addition of organic acids and/or polyols improved yield of fatty acids and reduced formation of emulsion. Lipid materials can be formulated with other agricultural products as new value-added animal feed products. Further, a process for concentrating nitrogenous compounds such as choline, inositol, ethanolamine and serine from phospholipid materials obtained as byproducts from vegetable oil refining is provided. The process involves performing hydrolysis of the gum based products in the presence of an alcoholic solvent and acid catalyst. Post hydrolysis, gums breakdown to oil and water phases which are further separated and concentrated. These concentrated products may be further fractionated to concentrate individual nitrogenous compounds.

公开(公告)号：US20220002226A1

公开(公告)日：2022-01-06

申请号：US17281732

申请日：2019-10-03

申请人： Hovione Scientia Limited

发明人： Susana SALDANHA ,  Antonio PARREIRA ,  Sara SEQUEIRA ,  Rafael ANTUNES

IPC分类号： C07C229/16 ,  A61K47/54 ,  A61K9/16 ,  C07C227/40

摘要： An amorphous form of a chelating agent is provided, in particular wherein the chelating agent comprises ethylenediaminetetraacetic acid/edetic acid (EDTA), diethylenetriaminepentaacetic acid/pentetic acid (DTPA), nitrilotriacetic acid (NTA), amino tris(methylenephosphonic acid) (ATMP), ethylenediamine tetramethylene phosphonic acid (EDTMP), 1-hydroxyethane 1,1-diphosphonic acid (HEDP), ethylenediaminedisuccinic acid (EDDS), iminodisuccinic acid (IDS), hydroxamic acid, oxalic acid, galactaric acid, metaphosphoric acid, or phytic acid, or a salt of any one or more of the above acids, or a mixture of two or more of any of the above acids or salts thereof.
A process for preparing an amorphous form of a chelating agent comprises the steps of: a) Dissolving the chelating agent in a suitable solvent; b) Optionally purifying the solution; c) Isolating an amorphous form of the chelating agent; d) Optionally post drying or conditioning the amorphous form of the chelating agent.

公开(公告)号：US10975031B2

公开(公告)日：2021-04-13

申请号：US15109286

申请日：2014-01-07

申请人： NOVASEP PROCESS

发明人： Damien Brichant ,  Frédéric Schab ,  Stanislas Baudouin ,  Vincent Oriez

IPC分类号： C07D209/20 ,  C07D233/64 ,  C07C227/40 ,  C07C229/34 ,  B01J39/04 ,  B01J39/20 ,  B01J39/05

摘要： A method for purifying an amino acid from an initial mixture is disclosed, in which the amino acid includes an aromatic ring and has an acidity constant Ka, the method including: a first step of putting the initial mixture into contact with a strong cation resin, at a pH greater than or equal to pKa; and a second elution step with an aqueous solution of eluent having a pH greater than the pH of the first step, giving the possibility of collecting a flow enriched in the amino acid.

公开(公告)号：US10974168B2

公开(公告)日：2021-04-13

申请号：US15491018

申请日：2017-04-19

申请人： INV NYLON CHEMICALS AMERICAS, LLC

发明人： Alex Conradie ,  Gary J. Smith ,  Paul S. Pearlman ,  Gregory S. Kirby ,  Mariusz Kamionka

IPC分类号： C07C51/47 ,  B01D15/36 ,  C07C227/40 ,  C07C67/58 ,  B01D15/20 ,  B01D15/18 ,  C07C53/126 ,  C07C229/06

摘要： This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.

公开(公告)号：US10968466B2

公开(公告)日：2021-04-06

申请号：US16469746

申请日：2017-12-18

申请人： COVESTRO DEUTSCHLAND AG

发明人： Gernot Jäger ,  Ivonne Görtz ,  Giulio Lolli ,  Amgad Salah Moussa ,  Thomas Hamedinger

IPC分类号： C12P13/00 ,  C07C209/78 ,  C07C227/40 ,  C07C231/02 ,  C07C245/02 ,  C08G12/08 ,  C08G73/02

摘要： The present invention relates to a process for preparing aminobenzoic acid or an aminobenzoic acid conversion product, comprising the steps of: (I) providing an aqueous solution of aminobenzoic acid using a fermentation process; (II) adsorbing aminobenzoic acid; (III) desorbing aminobenzoic acid at a pH in the range from −0.8 to 3.0, preferably −0.5 to 3.0, more preferably 0.1 to 3.0, very preferably 0.5 to 2.5, very exceptionally preferably 1.0 to 2.0; (IV) obtaining the aminobenzoic acid from the desorbate obtained in step (III); (V) optionally further converting the aminobenzoic acid obtained in step (IV) to an aminobenzoic acid conversion product.

公开(公告)号：US20210040030A1

公开(公告)日：2021-02-11

申请号：US16979745

申请日：2019-03-12

申请人： Taminco BVBA

发明人： Kim Dumoleijn ,  Kristof Moonen ,  Daan Ruben Scheldeman ,  Angelo Lauwaerts ,  Dieter Ulrichts ,  Luc Joseph Jan Pinoy

IPC分类号： C07C227/40 ,  C07C229/12 ,  C02F1/469

摘要： Method of purifying an alkali metal salt of a compound of the general Formula (I) or Formula (II) wherein R1, R2 and R3 are independently H, an alkyl, an alkenyl, or a hydroxyalkyl radical containing from 1 to 18 carbon atoms, or from 1 to 6 carbon atoms; or wherein R1 and R2 form jointly together with the N atom a heterocyclic 5- or 6-membered ring; said method comprising providing a mixture comprising said, an alkali metal hydroxide and water, and subjecting the mixture to a step (X): (X) reducing the quantity of removing said alkali metal hydroxide from the mixture; wherein (A) said alkali metal hydroxide is reduced by subjecting said mixture to electrodialysis; and/or (B) said alkali metal hydroxide is reduced by adding an acid to said mixture.

公开(公告)号：US10858308B2

公开(公告)日：2020-12-08

申请号：US16476977

申请日：2018-01-10

申请人： Alectrona PTE. LTD.

发明人： Gaik Babikyan ,  Benjamin Jiaravanon

IPC分类号： C07C227/08 ,  C07C227/40 ,  A61P31/10 ,  A61P31/20 ,  A61P31/22 ,  A61P31/04 ,  C07C229/16

摘要： Disclosed are compounds having the following formula: (I) wherein R is an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −2; or R is a quaternary amine having the following formula: (Ia) wherein Ra and Rb are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −3.

公开(公告)号：US10343978B2

公开(公告)日：2019-07-09

申请号：US15880293

申请日：2018-01-25

申请人： Vitaworks IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C227/00 ,  C07C227/08 ,  C07C229/08 ,  C07C51/47 ,  C07C227/40 ,  C07C209/62 ,  C07C227/20

摘要： There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yield an oxime fatty acid; (2) reacting the oxime fatty acid with an alcohol or a primary amine or a secondary amine to prepare an ester or amide; (3) subjecting the oxime fatty acid ester or amide to the Beckmann rearrangement to yield a mixture of two amide fatty acids; (4) hydrolyzing the mixed amide fatty acids to produce long chain amino acid, long chain dibasic acid, short chain alkylamine, and alkanoic acid.