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公开(公告)号：US11311027B2
公开(公告)日：2022-04-26
申请号：US16176389
申请日：2018-10-31
IPC分类号： A23K10/12 , A23K20/10 , A23K50/80 , C12N1/20 , A23K50/10 , A23K20/105 , C12N9/10 , C12N9/04 , A23K20/147 , C12N15/10
摘要： Nutritive compositions containing an organism having attenuated or no poly(3-hydroxybutyrate) production are provided. These nutritive compositions are useful as feed, such as animal feed and feed additives for ruminants, non-ruminants and aquaculture, etc. Materials and methods for production of these organisms are provided.
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公开(公告)号：US11939611B2
公开(公告)日：2024-03-26
申请号：US15436315
申请日：2017-02-17
IPC分类号： C12P13/00 , C12M1/00 , C12M1/34 , C12N1/20 , C12P5/00 , C12P5/02 , C12P7/06 , C12P7/24 , C12P7/625 , C25B1/04 , F01D15/10 , F01K7/16 , F01K11/02
CPC分类号： C12P13/001 , C12M29/00 , C12M41/00 , C12N1/20 , C12P5/00 , C12P5/007 , C12P5/02 , C12P7/065 , C12P7/24 , C12P7/625 , C12P13/00 , C25B1/04 , F01D15/10 , F01K7/16 , F01K11/02 , F05D2220/31 , Y02E50/10 , Y02E50/30 , Y02E60/36
摘要： The present disclosure describes biocatalytic processes for producing a product, comprising providing an aqueous stream (AS) comprising at least one fermentable substrate and a gaseous stream (GS) comprising at least one of CO2/H2, H2, methane, and/or CO to a fermentation zone, wherein the GS and AS stream are optionally contacted and/or mixed; the fermentation zone comprising at least one organism capable of metabolizing an AS substrate and a GS substrate, wherein the fermentation operates at conditions to mixotrophically metabolize at least one gaseous substrate in the GS and at least one substrate in the AS, producing the product. The present disclosure also describes compositions comprising an AS, a GS, and an organism, wherein the organism or an equivalent or engineered equivalent thereof is a methanotroph or a hydrogen-metabolizing or CO-metabolizing chemolithotrophic organism, and wherein the organism is capable of mixotrophic metabolism of at least one gaseous substrate in the GS and at least one substrate in the AS. The present disclosure also describes a process wherein said fermentation operates at conditions to mixotrophically metabolize at least H2 in the gaseous stream and glycerol and lactic acid in the aqueous stream. The present disclosure also describes a system for producing a fermentation or bio-derived product.
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公开(公告)号：US10975363B2
公开(公告)日：2021-04-13
申请号：US16372072
申请日：2019-04-01
摘要： Provided herein are novel, synthetic polypeptides having, for example, acyl-acyl carrier protein (ACP) thioesterase (TE) activity, including polypeptides that convert pimeloyl-ACP to pimelic acid. In some aspects, the synthetic polypeptides have advantageous enzymatic activity and/or improved substrate specificity relative to a wild type acyl-ACP TE.
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公开(公告)号：US12090420B2
公开(公告)日：2024-09-17
申请号：US16572899
申请日：2019-09-17
发明人： Gary J. Smith , Paul S. Pearlman , Gregory S. Kirby , Richard R. Rosin , Taylor Craig Schulz , Michael James Sargent
IPC分类号： B01D11/02 , B01D11/04 , B01D15/38 , B01J39/05 , C02F1/66 , C07C209/84 , C07C209/86 , C02F103/36
CPC分类号： B01D11/0488 , B01D15/3857 , B01J39/05 , C02F1/66 , C07C209/84 , C07C209/86 , C02F2103/36 , C02F2305/14
摘要： The present disclosure generally relates to methods for the recovery of amines from aqueous mixtures. In particular, the disclosure relates to methods for separating amines from amine-containing aqueous mixtures by adjusting the pH of the aqueous mixture relative to the highest pKa value for the amines.
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公开(公告)号：US12065636B2
公开(公告)日：2024-08-20
申请号：US16372106
申请日：2019-04-01
摘要： Provided herein are systems and methods for recycling and supplementing off-gas from a gas fed reaction process. The systems and methods are particularly useful for bioprocesses that convert hydrogen gas into one or more biosynthetic products. By maintaining separate hydrogen and oxygen feed gas streams, and forming a recycle gas that introduces a target component of the supply gas to the bioreactor within a target concentration range, the yields, productivities, and safety profiles of the bioprocess can be enhanced.
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公开(公告)号：US11512276B2
公开(公告)日：2022-11-29
申请号：US16372099
申请日：2019-04-01
摘要： The present disclosure provides methods for controlling oxygen concentration during aerobic biosynthesis, e.g., fermentation. The method may comprise feeding an oxygen-containing gas into a vessel including a fermentation feedstock and reacting the fermentation feedstock with the oxygen-containing gas to form a broth including a gaseous phase dispersed within the broth. The gaseous phase may comprise any unreacted oxygen from the oxygen-containing gas. The method further includes reducing the concentration of the unreacted oxygen in the dispersed gaseous phase to less than the limiting oxygen concentration (“LOC”) for flammability before separating the gaseous phase from the fermentation broth. The concentration of the unreacted oxygen in the gaseous phase is reduced by employing oxygen removal schemes or oxygen dilution schemes.
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公开(公告)号：US11203771B2
公开(公告)日：2021-12-21
申请号：US16372083
申请日：2019-04-01
摘要： This disclosure relates to strategies for in vivo production of certain carbon-based products, for example, aminated aliphatic compounds having a carbon chain length of C5-C19.
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公开(公告)号：US11674160B2
公开(公告)日：2023-06-13
申请号：US16441511
申请日：2019-06-14
发明人： Gary Smith , Paul S. Pearlman , Gregory S. Kirby
摘要： Methods, systems and compositions for producing at least one light-boiling, volatile, organic product using at least a portion of one or more carbon containing substances from a non-biosynthetic process in a biosynthetic process are provided. These methods, systems and compositions are useful in reducing waste treatment load of carbon containing chemical process waste streams.
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公开(公告)号：US10974168B2
公开(公告)日：2021-04-13
申请号：US15491018
申请日：2017-04-19
IPC分类号： C07C51/47 , B01D15/36 , C07C227/40 , C07C67/58 , B01D15/20 , B01D15/18 , C07C53/126 , C07C229/06
摘要： This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.
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