公开(公告)号：US08895782B2

公开(公告)日：2014-11-25

申请号：US14162672

申请日：2014-01-23

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Jennifer Gage ,  Feng Hong

IPC: C07D213/00 ,  C07C235/34 ,  C07C215/42 ,  C07D335/02 ,  C07C217/48 ,  C07C211/27 ,  C07C215/30 ,  C07D309/12 ,  C07C217/64 ,  C07D213/38

CPC classification number: C07C215/68 ,  C07C211/27 ,  C07C211/30 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/14 ,  C07C217/48 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C235/34 ,  C07C237/20 ,  C07C251/40 ,  C07C255/58 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C323/36 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/32 ,  C07D213/14 ,  C07D213/38 ,  C07D309/06 ,  C07D309/10 ,  C07D309/12 ,  C07D333/06 ,  C07D333/16 ,  C07D335/02

Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

公开(公告)号：US12226647B2

公开(公告)日：2025-02-18

申请号：US17052906

申请日：2019-05-03

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Amitava Gupta

IPC: A61N5/06 ,  A61N5/067 ,  G02C7/04

Abstract: A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.

公开(公告)号：US12147092B2

公开(公告)日：2024-11-19

申请号：US18051804

申请日：2022-11-01

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Gordon Frederick Maccabee ,  Ferry Widjaja ,  Amitava Gupta

IPC: G02C11/00 ,  G02C7/04 ,  A61N5/06

Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

公开(公告)号：US12105362B2

公开(公告)日：2024-10-01

申请号：US18330010

申请日：2023-06-06

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Amitava Gupta ,  Stefan Bauer ,  Benjamin Crook ,  Julien Sauvet

IPC: G02C7/08 ,  G02C7/02 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14

CPC classification number: G02C7/08 ,  G02C7/022 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14 ,  G02C2202/24

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US12037334B2

公开(公告)日：2024-07-16

申请号：US17279422

申请日：2019-09-27

Applicant: ACUCELA INC.

Inventor： Mark W. Orme ,  Edison S. Zuniga ,  Vladimir A. Kuksa ,  Russell Stuart Craft ,  Eduardo Moreno Saveedra ,  Johannes Wilhelm Georg Meissner ,  Jacobus Antonius Joseph den Hartog ,  Albert Cornelis Dros

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

公开(公告)号：US11986669B2

公开(公告)日：2024-05-21

申请号：US18153000

申请日：2023-01-11

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Karim Haroud ,  Beat Wyss ,  Hans Bernhard ,  Jean-Noel Fehr ,  Patrizia Weber ,  Moritz Haeberli ,  Amitava Gupta

IPC: A61N5/06 ,  G02B27/01 ,  G02B27/30

CPC classification number: A61N5/0622 ,  G02B27/0172 ,  G02B27/30 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US11911105B2

公开(公告)日：2024-02-27

申请号：US18005888

申请日：2021-09-30

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi

IPC: A61B3/103 ,  A61B3/00 ,  A61B3/10 ,  A61B3/135 ,  A61B3/14

CPC classification number: A61B3/103 ,  A61B3/0025 ,  A61B3/1015 ,  A61B3/135 ,  A61B3/14 ,  A61B3/102

Abstract: Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.

公开(公告)号：US20240023805A1

公开(公告)日：2024-01-25

申请号：US18475666

申请日：2023-09-27

Applicant: ACUCELA INC.

Inventor： Christian OGGENFUSS ,  Karim HAROUD ,  Lukas SCHEIBLER ,  Matthias PFISTER ,  Urban SCHNELL ,  Stefan TROLLER ,  Ryo KUBOTA ,  Philip M. BUSCEMI

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/1005 ,  A61B3/132 ,  A61B2560/0431 ,  A61B2562/0214 ,  A61B2562/0257 ,  A61B2562/223

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20230414097A1

公开(公告)日：2023-12-28

申请号：US18452350

申请日：2023-08-18

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Stephan WYDER ,  Amitava GUPTA

IPC: A61B3/10 ,  G01B9/02091

CPC classification number: A61B3/102 ,  G01B9/02091 ,  G01B2290/45

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).

公开(公告)号：US20230363638A1

公开(公告)日：2023-11-16

申请号：US18040186

申请日：2021-08-10

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Stephan WYDER ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Cyril STOLLER

IPC: A61B3/10

CPC classification number: A61B3/102 ,  G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.