公开(公告)号：US11684682B2

公开(公告)日：2023-06-27

申请号：US17292479

申请日：2019-11-12

申请人： BRACCO IMAGING S.P.A.

发明人： Zsolt Baranyai ,  Simona Ghiani ,  Alessandro Maiocchi ,  Ivan Hawala

IPC分类号： A61K51/08 ,  A61P35/00 ,  C07K7/64

CPC分类号： A61K51/08 ,  A61P35/00 ,  C07K7/64

摘要： A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.

公开(公告)号：US20220370646A1

公开(公告)日：2022-11-24

申请号：US17771168

申请日：2020-10-20

申请人： BRACCO IMAGING S.P.A.

发明人： Zsolt BARANYAI ,  Mariangela BOCCALON ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Alessandro MAIOCCHI ,  Roberta MAZZON ,  Fabio TEDOLDI ,  Fulvio UGGERI

IPC分类号： A61K49/10

摘要： The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.

公开(公告)号：US11274308B2

公开(公告)日：2022-03-15

申请号：US17262835

申请日：2019-07-24

申请人： BRACCO IMAGING S.P.A.

发明人： Vittorio De Franciscis ,  Silvia Catuogno ,  Carla Lucia Esposito ,  Alessandro Maiocchi ,  Margherita Iaboni ,  Luisa Poggi ,  Erika Reitano

IPC分类号： C12N15/115 ,  C12Q1/68

摘要： The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.

公开(公告)号：US20220016275A1

公开(公告)日：2022-01-20

申请号：US17292479

申请日：2019-11-12

申请人： BRACCO IMAGING S.P.A.

发明人： Zsolt BARANYAI ,  Simona GHIANI ,  Alessandro MAIOCCHI ,  Ivan HAWALA

IPC分类号： A61K51/08 ,  C07K7/64 ,  A61P35/00

摘要： A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.

公开(公告)号：US20210395832A1

公开(公告)日：2021-12-23

申请号：US17292748

申请日：2019-11-08

申请人： BRACCO IMAGING S.P.A.

发明人： Andrea FERRARIS ,  Erika REITANO ,  Alessandro MAIOCCHI

IPC分类号： C12Q1/6886

摘要： Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.

公开(公告)号：US20210263122A1

公开(公告)日：2021-08-26

申请号：US17246135

申请日：2021-04-30

申请人： BRACCO IMAGING S.P.A.

发明人： Silvio AIME ,  Dario Livio LONGO ,  Sonia COLOMBO SERRA ,  Lorena CONSOLINO ,  Francesca ARENA

IPC分类号： G01R33/56 ,  A61B5/055 ,  A61K49/10 ,  G01R33/465 ,  G01R33/48

摘要： The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.

公开(公告)号：US11014942B2

公开(公告)日：2021-05-25

申请号：US16678082

申请日：2019-11-08

申请人： BRACCO IMAGING S.P.A.

发明人： Roberta Mazzon ,  Roberta Fretta ,  Pier Lucio Anelli

IPC分类号： C07F5/00 ,  A61K9/14 ,  A61K9/00 ,  C07C227/40 ,  A61K49/10 ,  A61K49/18

摘要： The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

公开(公告)号：US20210024500A1

公开(公告)日：2021-01-28

申请号：US17060396

申请日：2020-10-01

申请人： BRACCO IMAGING S.P.A.

发明人： Valeria BOI ,  Roberta NAPOLITANO ,  Luciano LATTUADA

IPC分类号： C07D403/12 ,  C07D257/02 ,  A61K49/12

摘要： The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20200325108A1

公开(公告)日：2020-10-15

申请号：US16916817

申请日：2020-06-30

申请人： BRACCO IMAGING S.P.A.

发明人： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC分类号： C07D257/02 ,  A61K49/10 ,  C07D401/06

摘要： The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US10793533B2

公开(公告)日：2020-10-06

申请号：US16468035

申请日：2017-12-11

申请人： BRACCO IMAGING S.P.A.

发明人： Valeria Boi ,  Roberta Napolitano ,  Luciano Lattuada ,  Giovanni Battista Giovenzana

IPC分类号： C07D257/02 ,  A61K49/10 ,  C07D403/12 ,  A61K49/12

摘要： The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.