公开(公告)号：US11123304B2

公开(公告)日：2021-09-21

申请号：US16483170

申请日：2017-02-03

申请人： The Brigham and Women's Hospital, Inc.

发明人： Omid C. Farokhzad ,  Jun Wu ,  Xi Zhu ,  Jinjun Shi

IPC分类号： A61K9/51 ,  A61P3/10 ,  A61K31/337 ,  A61K38/28 ,  A61K39/35 ,  A61K39/00

摘要： This disclosure relates to nanoparticles comprising a core comprising a poly(ester amide) polymer comprising a repeating unit of Formula (Ia): and a repeating unit of Formula (Ib): wherein W1, W2, X1, A1, X2, A2, and X3 are as described herein, a payload molecule within the core, and a surface layer comprising a targeting ligand that binds or reacts selectively with a receptor on the outside surface of a cell. Methods of making such nanoparticles, and methods of using such nanoparticles as drug delivery vehicles, are also provided.

公开(公告)号：US20210283185A1

公开(公告)日：2021-09-16

申请号：US17257923

申请日：2019-07-03

申请人： Mayo Foundation for Medical Education and Research ,  The Brigham and Women's Hospital, Inc.

发明人： James L. Kirkland ,  Tamar Tchkonia ,  Stefan Tullius ,  Ming Xu ,  Joao Passos

IPC分类号： A61K35/28 ,  A61K31/506 ,  A61K31/353 ,  A01K67/027 ,  A61P39/00

摘要： This document provides methods and materials for treating aging and/or improving transplant outcomes. For example, methods and materials for using one or more senotherapeutic agents to reduce risk of transplant rejection are provided. Non-human animal models for transplant rejection as well as methods for using such non-human animal models to identify agents having the ability to reduce transplant rejection are provided as are non-human animal models for aging and methods for using such non-human animal models to identify agents having the ability to treat aging or the ability to slow the effects of aging.

公开(公告)号：US11096552B2

公开(公告)日：2021-08-24

申请号：US15741171

申请日：2015-06-30

申请人： CANON U.S.A., INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL INC. ,  Nobuhiko Hata ,  Takahisa Kato ,  Kiyoshi Takagi ,  Hidekazu Kose

发明人： Nobuhiko Hata ,  Takahisa Kato ,  Kiyoshi Takagi ,  Hidekazu Kose

IPC分类号： A61B1/00 ,  A61B1/005 ,  B25J9/16 ,  A61B34/30 ,  A61B1/018 ,  B25J9/10 ,  B25J13/06 ,  B25J18/06

摘要： The present invention provides a method and an apparatus for controlling a flexible manipulator including a plurality of bendable mechanisms via a control apparatus. The control apparatus includes a drive-mode selecting unit allows for the selection of a movement mode which may provide a bending movement, an angled view movement, or a remote center movement.

公开(公告)号：US11083780B2

公开(公告)日：2021-08-10

申请号：US15746307

申请日：2016-07-20

申请人： The Brigham and Women's Hospital, Inc. ,  The General Hospital Corporation

发明人： Ali Khademosseini ,  Rahmi Oklu

IPC分类号： A61K38/39 ,  A61P7/00 ,  A61K9/00 ,  A61K9/06 ,  A61K47/02

摘要： This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas.

公开(公告)号：US20210228493A1

公开(公告)日：2021-07-29

申请号：US17001237

申请日：2020-08-24

申请人： The Brigham and Women's Hospital, Inc.

发明人： Omid Farokhzad ,  Jun Wu ,  Lili Zhao

IPC分类号： A61K9/51 ,  A61K9/50 ,  A61K9/00 ,  A61K47/60 ,  A61K47/59 ,  A61K47/64 ,  A61K47/69 ,  A61K38/38 ,  A61K38/28 ,  C08G81/00

摘要： Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (α-amino acid)-α,ω-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.

公开(公告)号：US11051892B2

公开(公告)日：2021-07-06

申请号：US14491796

申请日：2014-09-19

申请人： CANON U.S.A., INC. ,  The Brigham and Women's Hospital, Inc

发明人： Nobuhiko Hata ,  Takahisa Kato ,  Ichiro Okumura ,  Kiyoshi Takagi ,  Hidekazu Kose

IPC分类号： A61B1/00 ,  A61B1/005 ,  A61B34/30 ,  A61B34/00 ,  A61B17/00

摘要： An apparatus including a tendon-driven device such as an endoscope comprising a bendable body, a tendon attached to and extending a length of said body, and an actuator that will actuate said tendon based on a control signal from a controller. The controller is configured to send said control signal to said actuator and comprises a forward-kinematic-mapping unit that estimates an angular displacement, wherein the kinematic-mapping unit is configured for: providing a tension value of the tendon to obtain a desired angular displacement wherein the tension has a nonlinear relationship with the desired angular displacement based on information of friction where the tension is greater that would be calculated without including the effect of friction. The friction coefficient may be determined as it changes over time.

公开(公告)号：US20210164971A1

公开(公告)日：2021-06-03

申请号：US17267827

申请日：2019-08-15

申请人： The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College

发明人： David R. Walt ,  Limor Cohen ,  David A. Weitz ,  Nai Wen Cui ,  Yamei Cai

IPC分类号： G01N33/543 ,  G01N33/58

摘要： The invention provides high-sensitivity methods for detection and quantification of target analytes in liquid samples (e.g., biological or environmental samples). The methods can be multiplexed to allow simultaneous detection and quantification of multiple target analytes that are contained in the same sample. The invention also provides related compositions and kits.

公开(公告)号：US20210163440A1

公开(公告)日：2021-06-03

申请号：US16630677

申请日：2018-07-12

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  OHIO STATE UNIVERSITY

发明人： Kevin HODGETTS ,  Chien-Liang Glenn LIN

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D241/18 ,  A61P25/28

摘要： The present application provides pyridine, pyrimidine, and pyrazine derivatives that activate excitatory amino acid transporter 2 (EAAT2), and methods of using the derivatives for treating or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.

公开(公告)号：US11021687B2

公开(公告)日：2021-06-01

申请号：US15400877

申请日：2017-01-06

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Jeffrey Michael Karp ,  Robert Samuel Langer ,  Xiaolei Yin

IPC分类号： C12N5/071 ,  G01N33/50

摘要： A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-β inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.

公开(公告)号：US11020410B2

公开(公告)日：2021-06-01

申请号：US16482664

申请日：2018-02-05

申请人： The Brigham and Women's Hospital, Inc.

发明人： Jeffrey M. Karp ,  Nitin Joshi ,  Douglas Rioux ,  Nicholas Edward Sherman ,  Andrew John Pickering ,  Connor Francis Gallin

IPC分类号： A61K31/675 ,  A61K9/00 ,  A61K9/06 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/28

摘要： Self-assembled gels and methods of making thereof are described. A selective range of ratios between an organic solvent and optionally water, or an aqueous solution, allows for combinations of gelators (such as GRAS amphiphiles or prodrug-based gelators), co-gelators (such as anti-retrovirals), and solvents to form self-supporting hydrogels or organogels. The resulting gels may be used in methods of treating HIV and/or hepatitis.