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公开(公告)号：US10463742B2
公开(公告)日：2019-11-05
申请号：US16387407
申请日：2019-04-17
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K47/44 , A61K8/31 , A61Q17/04 , A61K9/12 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K47/12 , A61K31/137 , A61K31/192 , A61K47/02 , A61K9/00 , A61Q19/00 , A61Q19/10 , A61K8/34 , A61K8/36 , A61K47/10 , A61K45/06 , A61K47/24 , A61K47/06
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity or the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
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公开(公告)号：US20190307685A1
公开(公告)日：2019-10-10
申请号：US16216575
申请日：2018-12-11
发明人： Dov Tamarkin , Meir Eini , Doron Friedman
摘要： A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a nonsteroidal immunomodulating agent as a foam. The pressurized product includes a foamable composition including: a) a container accommodating a pressurized product; and b) an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a nonsteroidal immunomodulating agent; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.1% to about 5% by weight of a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof; v. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; vi. water; and vii. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
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公开(公告)号：US20190240239A1
公开(公告)日：2019-08-08
申请号：US16384589
申请日：2019-04-15
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz
IPC分类号： A61K31/65 , A61Q19/00 , A61K9/12 , A61K8/34 , A61K47/44 , A61K47/12 , A61K47/10 , A61K47/06 , A61K8/31 , A61K9/06 , A61K9/00 , A61K8/92 , A61K8/42 , A61K8/36
CPC分类号： A61K31/65 , A61K8/31 , A61K8/342 , A61K8/361 , A61K8/42 , A61K8/922 , A61K9/0014 , A61K9/06 , A61K9/122 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/44 , A61K2800/10 , A61K2800/48 , A61Q19/00
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
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公开(公告)号：US10369102B2
公开(公告)日：2019-08-06
申请号：US15493807
申请日：2017-04-21
发明人： Dov Tamarkin , Rita Keynan , David Schuz , Tal Berman
IPC分类号： A61K9/12 , A61K8/04 , A61Q19/00 , A61Q7/00 , A61Q5/00 , A61K47/44 , A61K47/38 , A61K47/36 , A61K47/32 , A61K47/34 , A61K47/26 , A61K47/14 , A61K47/10 , A61Q19/02 , A61K8/34 , A61K8/36 , A61K8/49 , A61Q19/08 , A61K8/31 , A61K8/86 , A61K9/00 , A61K9/107
摘要： Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
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公开(公告)号：US20190076356A1
公开(公告)日：2019-03-14
申请号：US16189767
申请日：2018-11-13
发明人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号： A61K9/12 , A61K8/362 , A61K8/37 , A61K8/49 , A61K8/86 , A61K8/04 , A61Q19/00 , A01N25/16 , A61K9/00
摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
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公开(公告)号：US20190060333A1
公开(公告)日：2019-02-28
申请号：US15999434
申请日：2018-08-20
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K31/70 , A61Q19/00 , A01N25/04 , A61Q7/00 , A01N25/16 , A61K8/04 , A61K8/06 , A61K8/34 , A61K31/4412 , A61K31/4164 , A61K31/20 , A61K31/155 , A61K9/12 , A61K9/00 , A61K8/362 , A61K8/36 , A61K9/107 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26
摘要： The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
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公开(公告)号：US20190022000A1
公开(公告)日：2019-01-24
申请号：US15919684
申请日：2018-03-13
发明人： Dov TAMARKIN , Doron FRIEDMAN , Meir EINI
IPC分类号： A61K9/12 , A01N25/16 , A61K31/505 , A61K31/015 , A61K36/00 , A61K31/70 , A61K31/551 , A61K31/522 , A61K31/52 , A61K31/497 , A61K31/44 , A61K31/433 , A61K31/425 , A61K31/4164 , A61K31/415
摘要： Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti-infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.
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98.发明授权公开(公告)号：US10137200B2
公开(公告)日：2018-11-27
申请号：US15915386
申请日：2018-03-08
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K8/31 , A61K47/06 , A61K9/12 , A61K47/02 , A61K45/06 , A61K47/24 , A61K31/192 , A61K31/137 , A61K8/34 , A61K47/10 , A61K8/36 , A61K9/00 , A61K31/65 , A61K31/4164 , A61K47/12 , A61K31/573 , A61K31/593 , A61K31/57 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent free composition.
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公开(公告)号：US20180064638A1
公开(公告)日：2018-03-08
申请号：US15699692
申请日：2017-09-08
发明人： Dov Tamarkin , Meir Eini , Yohan Hazot , Mitchell Shirvan , Tal Hetzroni Kedem , Rita Keynan
IPC分类号： A61K9/00 , A61K47/46 , A61K47/06 , A61K47/24 , A61K47/10 , A61K47/12 , A61K47/44 , A61K31/65 , A61K9/12
CPC分类号： A61K9/0014 , A61K9/122 , A61K31/65 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/44 , A61K47/46
摘要： Provided are compositions and methods for treating rosacea and acne. Specifically, a gel or foam composition having a tetracycline antibiotic and uses thereof for treating rosacea and acne are provided.
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100.发明授权公开(公告)号：US09884017B2
公开(公告)日：2018-02-06
申请号：US15639114
申请日：2017-06-30
发明人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号： A61K9/12 , A61K47/20 , A61Q19/00 , A61K47/26 , A61K47/38 , A61K9/00 , A61K47/14 , A61K8/04 , A61K8/46
CPC分类号： A61K9/122 , A61K8/046 , A61K8/46 , A61K9/0014 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/38 , A61K2800/31 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
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