公开(公告)号：US20230406930A1

公开(公告)日：2023-12-21

申请号：US18300169

申请日：2023-04-13

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Junyan JI ,  Ellen Dorothee MEUX ,  Satya Krishna Kishore RAVURI ,  Karin SCHOENHAMMER ,  Jacqueline Yvonne TYLER ,  Ilona Elisabeth VOLLRATH ,  Adithi Chandrasekhara BHARGAVA ,  Jeremy Jean-Pierre DUBOEUF

IPC: C07K16/28 ,  C07K16/32 ,  A61K47/26 ,  A61K47/20 ,  A61K47/22 ,  A61K9/08

CPC classification number: C07K16/2809 ,  C07K16/283 ,  C07K16/32 ,  C07K16/2887 ,  A61K39/00 ,  A61K47/20 ,  A61K47/22 ,  A61K9/08 ,  C07K2317/31 ,  A61K47/26

Abstract: The disclosure provides pharmaceutical compositions of therapeutic proteins and methods of using the same.

公开(公告)号：US20230385475A1

公开(公告)日：2023-11-30

申请号：US18447986

申请日：2023-08-10

Applicant: GENENTECH, INC.

Inventor： Jessica Yang LYALL ,  Connor James THOMPSON ,  Sean Mackenzie BURGESS

IPC: G06F30/17 ,  G06F30/20

CPC classification number: G06F30/17 ,  G06F30/20

Abstract: A method, system, and non-transitory computer readable medium for estimating mechanistic chromatography model uncertainty. A mechanistic model of chromatography that comprises a plurality of parameters is received. For each of the plurality of parameters, a corresponding region of values is identified based on a relationship between values for the plurality of parameters. Each parameter of the plurality of parameters is sampled within the corresponding region of values for each parameter to form a plurality of simulation sets. An uncertainty for the mechanistic model is quantified using the plurality of simulation sets.

公开(公告)号：US20230383008A1

公开(公告)日：2023-11-30

申请号：US18048763

申请日：2022-10-21

Applicant: Genentech, Inc.

Inventor： Robert F. KELLEY ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: C07K16/40 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/3955 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2039/507

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US20230381156A1

公开(公告)日：2023-11-30

申请号：US18449807

申请日：2023-08-15

Applicant: Genentech, Inc.

Inventor： Ciara METCALFE ,  Kui LIN ,  Marc Antoine HAFNER

IPC: A61K31/437 ,  A61K31/517

CPC classification number: A61K31/437 ,  A61K31/517

Abstract: Provided herein are combination therapies comprising GDC-9545 and ipatasertib for treating locally advanced breast cancer or metastatic breast cancer.

公开(公告)号：US11827639B2

公开(公告)日：2023-11-28

申请号：US16626191

申请日：2018-06-28

Applicant: Genentech, Inc. ,  NewLink Genetics Corporation

Inventor： Zhonghua Pei ,  Brendan Parr ,  Wendy Liu ,  Richard Pastor ,  Lewis Gazzard ,  Firoz Jaipuri ,  Sanjeev Kumar ,  Hima Potturi ,  Guoshen Wu ,  Xingyu Lin ,  Yanyan Chu ,  Powai Yuen

IPC: C07D487/04 ,  A61K31/4188 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/437 ,  A61K31/4725 ,  A61K31/5377 ,  A61K45/06

CPC classification number: C07D487/04

Abstract: Presently provided are inhibitors of TD02 and IDO1 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

公开(公告)号：US20230368863A1

公开(公告)日：2023-11-16

申请号：US18338772

申请日：2023-06-21

Applicant: Genentech, Inc.

Inventor： Man-Ling Lee ,  Alberto Emilio Gobbi ,  Christian Nathaniel Cunningham

IPC: G16B15/30 ,  G16B15/20 ,  G16B40/00

CPC classification number: G16B15/30 ,  G16B15/20 ,  G16B40/00

Abstract: Methods, systems, and computer program products are provided for clustering of similar peptides to detect candidates for target binding. In some embodiments, a method provided herein includes receiving sequencing information and quantification information of a plurality of peptides after target-binding selection in a library. The sequencing information includes amino acid sequences of the plurality of peptides, and the quantification information includes a count of copies of each amino acid sequence in the plurality of peptides. The method further includes computing similarity scores for pairs of the plurality of peptides using the sequencing information. The method further includes grouping the plurality of peptides into clusters based on the similarity scores. The method further includes screening the clusters based on quantification information of peptides in each cluster to obtain candidates for target binding over a pre-set threshold.

公开(公告)号：US20230365704A1

公开(公告)日：2023-11-16

申请号：US18310448

申请日：2023-05-01

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang KAO ,  Michael W. LAIRD ,  Melody Trexler SCHMIDT ,  Rita L. WONG ,  Daniel P. HEWITT

IPC: C07K16/28 ,  C07K1/14 ,  A61K39/395

CPC classification number: C07K16/2887 ,  C07K1/14 ,  A61K39/39591 ,  C07K2317/24

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US20230357418A1

公开(公告)日：2023-11-09

申请号：US18245372

申请日：2021-03-19

Applicant: Genentech, Inc.

Inventor： Shalini V. MOHAN ,  William George REISS ,  Hoi Ying Linda YAU ,  Benjamin Howard KRAMER ,  Jian HAN

IPC: C07K16/28 ,  A61K31/706 ,  A61K31/573 ,  A61P11/00

CPC classification number: C07K16/2866 ,  A61K31/706 ,  A61K31/573 ,  A61P11/00 ,  A61K2039/545

Abstract: The application disclosed concerns a method of treating pneumonia in a patient who is not mechanically ventilated comprising administering an IL-6 antagonist (e.g. tocilizumab) to the patient in an amount effective to prevent the patient from dying or receiving mechanical ventilation. The disclosure is based on the results of the EM PACTA clinical trial.

公开(公告)号：US20230348953A1

公开(公告)日：2023-11-02

申请号：US18043568

申请日：2021-08-31

Applicant: GENENTECH, INC.

Inventor： Li YI ,  Adithi Chandrasekhara BHARGAVA ,  Inn Huam YUK

IPC: C12Q1/44

CPC classification number: C12Q1/44 ,  G01N2333/918

Abstract: The present disclosure provides compositions, methods, and kits for detecting lipolytic activity. In some embodiments, the composition comprises an aqueous assay sample and an organic solvent, wherein the organic solvent comprises 4-methylumbellif-erryl caprylate (MU-C8). Also provided herein are methods for determining the stability of a protein preparation.

公开(公告)号：US20230339957A1

公开(公告)日：2023-10-26

申请号：US18334515

申请日：2023-06-14

Applicant: Genentech, Inc.

Inventor： Chen MAO ,  Dawen KOU ,  Po-Chang CHIANG

IPC: A61K9/14 ,  C07C309/04 ,  A61K31/4985 ,  C07D487/04 ,  A61K9/20 ,  A61K9/10

CPC classification number: C07D487/04 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2013 ,  A61K31/4985 ,  C07C309/04 ,  C07B2200/13

Abstract: The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound (S)-2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro- [3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton’s tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.