公开(公告)号：US07170078B2

公开(公告)日：2007-01-30

申请号：US10141555

申请日：2002-05-09

Applicant: Hitoshi Shimizu ,  Keiko Neriishi ,  Nobuhiko Ogura

Inventor： Hitoshi Shimizu ,  Keiko Neriishi ,  Nobuhiko Ogura

IPC: G03B42/08

CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N33/54373

Abstract: A biochemical analysis data producing method includes the steps of selectively storing one of radiation energy and light energy in a plurality of stimulable phosphor layer regions two-dimensionally formed in a support of a stimulable phosphor sheet and spaced apart from each other, moving the stimulable phosphor sheet and a stimulating ray relative to each other in a main scanning direction and a sub-scanning direction, sequentially irradiating the plurality of stimulable phosphor layer regions so that energy of the stimulating ray projected onto the plurality of stimulable phosphor layer regions per unit area is higher than that projected on regions other than the plurality of stimulable phosphor layer regions, thereby exciting stimulable phosphor contained in the plurality of stimulable phosphor layer regions, and photoelectrically detecting stimulated emission released from the stimulable phosphor layer to produce biochemical analysis data. According to this method, it is possible to effectively prevent the stimulating ray from entering a neighboring stimulable phosphor layer region to be next stimulated as the stimulating ray is scanned and thus prevent stimulable phosphor contained in the neighboring stimulable phosphor layer region from being excited to release radiation energy or light energy stored therein, and, therefore, biochemical analysis data having an excellent quantitative characteristic can be produced in a desired manner.

Abstract translation: 生物化学分析数据生成方法包括以下步骤：将辐射能量和光能中的一种选择性地存储在可激发的荧光体片的支撑体中二维地形成并且彼此间隔开的多个可刺激的荧光体层区域中，将可刺激的荧光体 并且在主扫描方向和副扫描方向上相对于彼此产生刺激光线，顺序地照射多个可刺激的荧光体层区域，使得投影到每单位面积的多个可激发荧光体层区域上的刺激光线的能量为 高于在多个可刺激的荧光体层区域以外的区域上投影的激光荧光体层，从而激发包含在多个可刺激的荧光体层区域中的可激发的荧光体，以及光电检测从可刺激的荧光体层释放的受激发射以产生生化分析数据。 根据该方法，可以有效地防止刺激光线随着刺激射线被扫描而进入下一个被刺激的刺激性射线区域，从而防止相邻可刺激荧光体层区域中包含的可刺激的荧光体被激发释放 辐射能量或光能存储在其中，因此可以以期望的方式产生具有优异定量特性的生化分析数据。

公开(公告)号：USD530235S1

公开(公告)日：2006-10-17

申请号：US29237425

申请日：2005-09-01

Applicant: Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

Designer： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

公开(公告)号：USD529829S1

公开(公告)日：2006-10-10

申请号：US29237422

申请日：2005-09-01

Applicant: Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

Designer： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

公开(公告)号：US07075654B2

公开(公告)日：2006-07-11

申请号：US11256151

申请日：2005-10-24

Applicant: Takashi Kubo ,  Katsuaki Muraishi ,  Toshihito Kimura ,  Hitoshi Shimizu ,  Nobufumi Mori

Inventor： Takashi Kubo ,  Katsuaki Muraishi ,  Toshihito Kimura ,  Hitoshi Shimizu ,  Nobufumi Mori

IPC: G01N21/55 ,  G01N21/01

CPC classification number: G01N21/553

Abstract: Disclosed herein is a measuring apparatus equipped with a plurality of measuring units. Each measuring unit includes a dielectric block, a thin film layer formed on the dielectric block, and a sample holding mechanism for holding a sample on the thin film layer. The measuring apparatus is further equipped with an optical system for making a light beam enter the dielectric block at an angle of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer, and photodetectors for measuring the intensity of the light beam totally reflected at the interface. The optical system is constructed so that light beams simultaneously enter the dielectric blocks of the measuring units. The number of photodetectors corresponds to the number of the light beams.

公开(公告)号：US07004589B2

公开(公告)日：2006-02-28

申请号：US10867728

申请日：2004-06-16

Applicant: Hitoshi Shimizu

Inventor： Hitoshi Shimizu

IPC: G03B21/14

CPC classification number: H04N9/3105 ,  G03B21/006 ,  G03B21/20 ,  G03B21/28 ,  H04N9/317

Abstract: A liquid crystal projector of three-color type has three liquid crystal elements for modulating three primary color light bundles into three color optical images respectively. A recombination prism combines modulated three color optical images, and a projection lens system projects the combined full-color image on a screen. The projection lens system is constituted of the front lens group and the first and second rear lens groups. The front lens group and the rear lens groups are mounted to frames that are formed integrally on a prism base plate to which the recombination prism is fixed.

Abstract translation: 三色液晶投影仪具有三个用于将三原色光束分别调制为三色光学图像的液晶元件。 复合棱镜组合调制的三色光学图像，并且投影透镜系统将组合的全色图像投影在屏幕上。 投影透镜系统由前透镜组和第一和第二后透镜组构成。 前透镜组和后透镜组安装到整体形成在复合棱镜固定到的棱镜基板上的框架上。

公开(公告)号：US06917481B2

公开(公告)日：2005-07-12

申请号：US10334779

申请日：2003-01-02

Applicant: Hitoshi Shimizu ,  Tadashi Iwasawa

Inventor： Hitoshi Shimizu ,  Tadashi Iwasawa

IPC: G02B7/00 ,  G02B7/02 ,  G02B27/00 ,  G03B21/14 ,  H04N5/74

CPC classification number: G02B7/00 ,  G02B27/0994 ,  H04N9/3141

Abstract: A rod integrator holder comprises a wall constituting at least a part of an intermediate portion interposed between a rod integrator in an illumination optical system or a holding member for the rod integrator, and an optical member disposed downstream the rod integrator or a holding member for the optical member. The intermediate portion tightly closes a space between a light entrance end of the optical member and a light exit end of the rod integrator against surroundings thereof.

Abstract translation: 杆状积分器保持器包括构成插入在照明光学系统中的杆积分器或杆积分器的保持构件之间的中间部分的至少一部分的壁，以及设置在杆积分器下游的光学构件或用于 光学构件。 中间部分紧密地关闭光学构件的光入射端和杆积分器的光出射端之间的空间，以防其周围。

公开(公告)号：US06897299B2

公开(公告)日：2005-05-24

申请号：US10363318

申请日：2001-08-31

Applicant: Hitoshi Shimizu ,  Kaname Tsuzaki ,  Mitsuhiro Kurita

Inventor： Hitoshi Shimizu ,  Kaname Tsuzaki ,  Mitsuhiro Kurita

IPC: A61P1/00 ,  C07H17/08 ,  C07H1/00

CPC classification number: A61K31/7048 ,  C07H17/08

Abstract: A method for preparing a fumarate salt of a compound represented by Formula (II): (wherein R1 represents a hydrogen atom or a lower alkyl group, and R2 represents a lower alkyl group), which comprises carbamating a compound represented by Formula (I): (wherein R1 represents a hydrogen atom or a lower alkyl group), removing all carbamate groups from this compound, alkylating the nitrogen atom at the 3′-position of the desosamine ring in the resulting compound to give the compound represented by Formula (II), and converting this compound into a fumarate salt, wherein the compound represented by Formula (I) is carbamated in the presence of a cyclic ether or a carboxylic ester. This method enables efficient preparation of high-quality erythromycin derivatives.

Abstract translation: 一种制备由式（II）表示的化合物的富马酸盐的方法：其中R 1表示氢原子或低级烷基，R 2表示 低级烷基），其包括将式（I）表示的化合物氨基甲酸酯化：（其中R 1表示氢原子或低级烷基），从该化合物中除去所有氨基甲酸酯基团，将氮烷基化 （II）表示的化合物，并将该化合物转化成富马酸盐，其中式（I）所示的化合物在氨基甲酸酯化反应的存在下进行氨基甲酸酯化反应 环醚或羧酸酯。 该方法能够高效地制备高品质的红霉素衍生物。

公开(公告)号：US20050046854A1

公开(公告)日：2005-03-03

申请号：US10932071

申请日：2004-09-02

Applicant: Yoshiyuki Kunuki ,  Hitoshi Shimizu ,  Toshihito Kimura

Inventor： Yoshiyuki Kunuki ,  Hitoshi Shimizu ,  Toshihito Kimura

IPC: G01N21/55

CPC classification number: G01N21/553

Abstract: A sensor unit includes a dielectric block, a thin film layer and a reference surface. The thin film layer is formed on the upper surface of the dielectric block and the reference surface is coplanar with the upper surface of the dielectric block. The sensor unit is held in a predetermined position. A light beam is caused to enter the dielectric block to impinge upon the interface between the upper surface of the dielectric block and the thin film layer so that total internal reflection conditions are satisfied at the interface. Information on an analyte on the thin film layer is obtained on the basis of the light beam reflected at the interface. Displacement of the interface is measured by measuring displacement of the reference surface and the position of the sensor unit is adjusted according to the displacement of the reference surface.

Abstract translation: 传感器单元包括介质块，薄膜层和参考表面。 在介质块的上表面上形成薄膜层，并且参考表面与介质块的上表面共面。 传感器单元保持在预定位置。 导致光束进入介电块以撞击在介质块的上表面和薄膜层之间的界面上，使得在界面处满足全内反射条件。 基于在界面处反射的光束获得关于薄膜层上的分析物的信息。 通过测量参考表面的位移来测量界面的位移，并且根据参考表面的位移调节传感器单元的位置。

公开(公告)号：US06858863B2

公开(公告)日：2005-02-22

申请号：US10094733

申请日：2002-03-08

Applicant: Hitoshi Shimizu ,  Kouji Kumada ,  Norihiro Iwai

Inventor： Hitoshi Shimizu ,  Kouji Kumada ,  Norihiro Iwai

IPC: H01S5/343 ,  H01S5/183 ,  H01S5/20 ,  H01S5/32 ,  H01S5/323 ,  H01S5/34 ,  H01L29/06

CPC classification number: B82Y20/00 ,  H01S5/18311 ,  H01S5/2068 ,  H01S5/3209 ,  H01S5/32366 ,  H01S5/32375 ,  H01S5/3403 ,  H01S5/34306 ,  H01S5/34353

Abstract: A semiconductor laser device includes a resonant cavity formed on a GaAs substrate, the resonant cavity including a quantum well (QW) active layer structure having a GaInNAs(Sb) well layer and a pair of barrier layers. The QW structure has a conduction band offset energy (ΔEc) equal to or higher than 350 milli-electron-volts (meV) between the well layer and the barrier layers, and each of the barrier layers a tensile strain equal to or lower than 2.5%.

Abstract translation: 半导体激光器件包括形成在GaAs衬底上的谐振腔，所述谐振腔包括具有GaInNA（Sb）阱层和一对阻挡层的量子阱（QW）有源层结构。 QW结构具有等于或高于阱层与阻挡层之间的350毫伏电压（meV）的导带偏移能量（DeltaEc），并且每个阻挡层的拉伸应变等于或小于2.5 ％。

公开(公告)号：US06693269B2

公开(公告)日：2004-02-17

申请号：US09922929

申请日：2001-08-07

Applicant: Hitoshi Shimizu ,  Shu Sato ,  Taizo Akimoto

Inventor： Hitoshi Shimizu ,  Shu Sato ,  Taizo Akimoto

IPC: H01L2700

CPC classification number: G01T1/208

Abstract: A photomultiplier which detects feeble light emitted by the irradiation of excitation light on an image carrier carrying an image related to a living organism has an integration circuit is DC-coupled with a photomultiplier to convert a current signal output from the photomultiplier, to a voltage signal. The voltage signal converted by the integration circuit is logarithmically compressed with a logarithmic conversion circuit. An offset compensation circuit is provided for reducing an offset voltage that could occur because of charge injection in the integral action of the integration circuit.

Abstract translation: 检测由携带有机体的图像的图像载体上的激发光照射发出的微弱光的光电倍增管与光电倍增管DC耦合，将从光电倍增管输出的电流信号转换为电压信号 。 由积分电路转换的电压信号用对数转换电路进行对数压缩。 提供了一种偏移补偿电路，用于减少由于集成电路的积分作用中的电荷注入而可能发生的偏移电压。