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公开(公告)号：US09458220B2
公开(公告)日：2016-10-04
申请号：US14563362
申请日：2014-12-08
Inventor： Richard D. DiMarchi , Yulia Azriel , Zachary Kaur , Jonathan Meyers , Todd Parody , Yan Zhao
Abstract: Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin A and B chains, or analogs or derivatives thereof, wherein the carboxy terminus of the B25 amino acid of the B chain is linked to the amino terminus of the A1 amino acid of the A chain via the intervening linking moiety. In on embodiment the linking moiety comprises a polyethylene glycol of 6-16 monomer units and in an alternative embodiment the linking moiety comprises a non-native amino acid sequence derived form the IGF-1 C-peptide and comprising at least 8 amino acids and no more than 12 amino acid in length. Also disclosed are prodrug and conjugate derivatives of the single chain insulin analogs.
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公开(公告)号：US09454888B2
公开(公告)日：2016-09-27
申请号：US14923852
申请日：2015-10-27
Inventor： Jian Xie , Jie Chen , Lingxi Li , Yaobin Chen
CPC classification number: G08B21/185 , G01R31/3606 , G01R31/3651 , G01R31/3658 , G01R31/3675 , G08B29/181
Abstract: Systems, apparatuses and methods for detecting internal cell faults using online and real-time sensing techniques, and providing an accurate and reliable early warning for the incoming failure of battery cells hours or days prior to failure. A system is configured to perform real-time and direct measurement of battery cell parameters of temperature, voltage, and AC impedance through online sensing. These parameters may be simultaneously processed using advanced probabilistic and/or fuzzy logic-based algorithms to provide an early warning for the incoming failure of battery cells in a battery pack. This technology may safeguard the LIB battery packs while allowing them to operate at or near 100% capacity in both transportation and stationary applications.
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93.发明申请USE OF ACAMPROSATE TO MODULATE ERK1/2 ACTIVATION IN ANIMAL MODELS FOR FXS AND ASD AND INDIVIDUALS DIAGNOSED WITH FXS AND ASD 审中-公开在FXS和ASD以及用FXS和ASD诊断的个体的动物模型中使用抗坏血酸调节ERK1 / 2的活化公开(公告)号：US20160266120A1
公开(公告)日：2016-09-15
申请号：US15029596
申请日：2014-10-14
Inventor： Craig Erickson , Debomoy Lahiri
IPC: G01N33/573 , A61K31/16
CPC classification number: G01N33/573 , A61K31/16 , A61K31/185 , G01N2333/4709 , G01N2333/48 , G01N2333/91205 , G01N2500/20 , G01N2800/2814 , G01N2800/52
Abstract: Studies in mouse models of Fragile X and preliminary studies in human youth demonstrate that ERK1/2 is biomarker useful to monitoring the treatment of people diagnosed with ASD. Results reported herein demonstrate that acamprosate has the ability to reduce levels of ERK1/2 activation associated with many of the symptoms of ASD. Accordingly, in addition to its utility as a diagnostic marker for ASD ERK1/2 activation levels can be used to monitory patients treated with acamprosate.
Abstract translation: 对脆性X的小鼠模型的研究和人类青年的初步研究表明ERK1 / 2是生物标志物可用于监测诊断为ASD的人的治疗。 本文报道的结果表明，acamprosate具有降低与许多ASD症状相关的ERK1 / 2激活水平的能力。 因此，除了其作为ASD ERK1 / 2的诊断标志物的作用之外，活化水平可用于用阿坎酸治疗的临床患者。
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公开(公告)号：US09420770B2
公开(公告)日：2016-08-23
申请号：US14491183
申请日：2014-09-19
Inventor： Alfred Joseph Tector, III , Christopher Burlak
IPC: G01N33/00 , A01K67/00 , A01K67/033 , A01K67/027 , A61K35/407
CPC classification number: A01K67/0276 , A01K2227/108 , A01K2267/025 , A61K35/407
Abstract: The application provides methods of modulating platelet uptake by liver sinusoidal endothelial cells and of modulating thrombocytopenia. Transgenic pigs modified to bind fewer platelets are provided.
Abstract translation: 该应用提供了调节肝窦内皮细胞血小板摄取和调节血小板减少症的方法。 提供了修饰以结合较少血小板的转基因猪。
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公开(公告)号：US20160233790A1
公开(公告)日：2016-08-11
申请号：US15023228
申请日：2014-09-19
Inventor： Afshin IZADIAN
IPC: H02M7/797
CPC classification number: H02M7/797 , H02J3/28 , H02J7/022 , H02M2007/2195 , H02M2007/4815 , Y02B70/1408 , Y02B70/1441
Abstract: A bidirectional AC-to-DC and DC-to-AC circuit includes a first inductor-capacitor (LC) circuit connected to an AC power source, a transistor synchronized with the AC power source signal, a second LC circuit electrically connected to the synchronized transistor and the first inductor-capacitor circuit, a high-frequency switching transistor electrically connected to the second inductor-capacitor circuit and a direct current (DC) load, and a controller connected to the high-frequency switching transistor. The controller identifies an error between a measured DC output signal and a predetermined DC output signal that is applied to the DC load, and adjusts a duty cycle of a pulse width modulation (PWM) switching signal for the high-frequency transistor to reduce the identified error.
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Patent Agency Ranking
公开(公告)号：US20160222388A1
公开(公告)日：2016-08-04
申请号：US15009339
申请日：2016-01-28
Inventor： Timothy Corson , Halesha Basavarajappa
IPC: C12N15/113 , A61K31/353 , A61K39/395 , C07K16/22 , A61K31/343 , A61K9/00
CPC classification number: C12N15/1137 , A61K9/0019 , A61K31/343 , A61K31/409 , A61K31/713 , A61K45/06 , C12N2310/14 , C12Y499/01001
Abstract: Methods for treating angiogenesis-mediated diseases are disclosed. More particularly, the present disclosure relates to methods of inhibiting ferrochelatase as an antiangiogenic therapy.
Abstract translation: 公开了治疗血管生成介导的疾病的方法。 更具体地，本公开涉及抑制铁螯合酶作为抗血管生成疗法的方法。
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公开(公告)号：US20160216236A1
公开(公告)日：2016-07-28
申请号：US15087255
申请日：2016-03-31
Inventor： David Edward Clemmer , Michael A. Ewing , Steven M. Zucker , Christopher R. P. Conant
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: In a linear drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a system and method of separating ions includes repeatedly establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube in one direction, and when the ions reach the end of the drift tube the electric drift fields are reversed and the process is repeated to transmit the ions to the opposite end of the drift tube. Ions may be made to pass back and forth through the drift tube any number of times before being drawn out of the drift tube to an ion detector or into another drift tube.
Abstract translation: 在分离成多个级联的漂移管段的线性漂移管中，每个随后都有离子消除区，分离离子的系统和方法包括在建立漂移管段和一些离子消除区域中重复建立电漂移场 离子消除区域的其他电斥斥场，使得具有预定迁移率或迁移率范围的离子在一个方向上透过漂移管，当离子到达漂移管的末端时，电漂移场相反，并且 重复处理以将离子传输到漂移管的相对端。 任何次数的离子可以在漂移管被抽出离子检测器或另一个漂移管之前来回穿过漂移管。
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公开(公告)号：US20160209363A1
公开(公告)日：2016-07-21
申请号：US15023575
申请日：2014-09-23
Inventor： David E. CLEMMER , Michael A. Ewing
IPC: G01N27/62
CPC classification number: G01N27/622
Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet at one end and an ion outlet at an opposite end, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and a set of ion gates each controllable between an open position to pass ions therethrough and a closed position to block ions from passing therethrough. The set of ion gates may be controlled to pass at least some ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to pass at least some ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube.
Abstract translation: 混合离子迁移谱仪包括一端具有离子入口和相对端的离子出口的单通漂移管，具有离子入口和离子出口的多通漂移管，每个离子入口和离子出口各自耦合到单程漂移管 在离子入口和离子出口之间，以及一组离子门，每个离子门都可以在通过离子的打开位置和闭合位置之间控制，以阻止离子通过。 可以控制该组离子浇口使至少一些通过单通漂移管传播的离子通过多通漂移管的离子入口传递到多通漂移管中，并使至少一些离子通过 多通漂移管通过多通漂移管的离子出口进入单程漂移管。
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公开(公告)号：US09376385B2
公开(公告)日：2016-06-28
申请号：US14630183
申请日：2015-02-24
Inventor： Erin C. Carlson , Darci Trader , Ashley Sidebottom
IPC: C07F7/04 , C07D207/36 , C07D273/00 , C07D273/01 , C08F8/30 , C08F8/42
CPC classification number: C07D207/36 , C07D273/00 , C07D273/01 , C08F8/30 , C08F8/42 , C08F112/08
Abstract: The present disclosure relates to solid-phase azide supports, methods for making solid-state azide supports, and methods for capturing alkynes using the same. The present disclosure also relates to kits for solid-phase azide supports.
Abstract translation: 本公开内容涉及固相叠氮化物载体，制备固态叠氮化物载体的方法，以及使用其的炔烃捕获方法。 本公开还涉及用于固相叠氮化物载体的试剂盒。
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公开(公告)号：US20160181798A1
公开(公告)日：2016-06-23
申请号：US14906879
申请日：2014-07-22
Inventor： Afshin IZADIAN
Abstract: A bidirectional AC-to-DC and DC-to-AC circuit includes a first inductor-capacitor (LC) circuit connected to an AC power source, a transistor synchronized with the AC power source signal, a second LC circuit electrically connected to the synchronized transistor and the first inductor-capacitor circuit, a high-frequency switching transistor electrically connected to the second inductor-capacitor circuit and a direct current (DC) load, and a controller connected to the high-frequency switching transistor. The controller identifies an error between a measured DC output signal and a predetermined DC output signal that is applied to the DC load, and adjusts a duty cycle of a pulse width modulation (PWM) switching signal for the high-frequency transistor to reduce the identified error.
Abstract translation: 双向AC-DC和DC-AC电路包括连接到AC电源的第一电感器 - 电容器（LC）电路，与AC电源信号同步的晶体管，电连接到同步的第二LC电路 晶体管和第一电感器 - 电容器电路，与第二电感器 - 电容器电路和直流（DC）负载电连接的高频开关晶体管，以及连接到高频开关晶体管的控制器。 控制器识别测量的直流输出信号和施加到直流负载的预定直流输出信号之间的误差，并调整用于高频晶体管的脉宽调制（PWM）切换信号的占空比，以减少所识别的 错误。
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