公开(公告)号：US4109855A

公开(公告)日：1978-08-29

申请号：US844607

申请日：1977-10-25

申请人： Richard I. Brown ,  Joseph K. Duffy

发明人： Richard I. Brown ,  Joseph K. Duffy

IPC分类号： B04B5/04 ,  B04B9/08 ,  B04B5/02

CPC分类号： B04B5/0442 ,  B04B9/08

摘要： Centrifugal processing apparatus in which a processing chamber is rotatably mounted with respect to a stationary base. An umbilical cable segment is fixed at one end substantially along the axis of the processing chamber at one side thereof, with the other end of the cable segment being attached substantially on the axis in rotationally locked engagement to the processing chamber. A coaxial main drive shaft is provided and is driven at a first angular velocity. The cable segment extends from its location in rotationally locked engagement to the processing chamber, through a central bore defined by the main drive shaft and radially outwardly therefrom. Power is transmitted to the processing chamber via a transmission countershaft which is parallely located with respect to the main drive shaft and operative to turn in the direction opposite to the direction of the main drive shaft. The countershaft is coupled so that when the main drive shaft is driven at the first angular velocity, the processing chamber will effectively rotate at twice the first angular velocity. The construction of the processing system is such that the drive is substantially hidden and requires a relatively small number of seals.

摘要翻译： 处理室相对于固定基座可旋转地安装的离心处理装置。 脐带缆段在其一侧基本上沿着处理室的轴线固定在一端，电缆段的另一端基本上被附接在轴线上，以与处理室旋转锁定接合。 提供同轴主驱动轴并且以第一角速度被驱动。 电缆段通过由主驱动轴限定的中心孔并从其径向向外从旋转锁定的接合位置延伸到处理室。 动力通过传动中间轴传递到处理室，该传动中间轴相对于主驱动轴平行定位并且可在与主驱动轴的方向相反的方向上转动。 中间轴联接，使得当主驱动轴以第一角速度被驱动时，处理室将有效地以第一角速度的两倍旋转。 处理系统的结构使得驱动器基本上是隐藏的并且需要相对较少数量的密封件。

公开(公告)号：US4109854A

公开(公告)日：1978-08-29

申请号：US805950

申请日：1977-06-13

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： B04B5/04 ,  B04B9/08 ,  B04B5/02 ,  B04B9/00

CPC分类号： B04B5/0442 ,  B04B9/08 ,  B04B2005/0492

摘要： Centrifugal processing apparatus in which a processing chamber is rotatably mounted with respect to a stationary base. An umbilical cable segment is fixed at one end substantially along the axis of the processing chamber at one side thereof, with the other end of the cable segment being attached substantially on the axis in rotationally locked engagement to the processing chamber. An outer enclosure is positioned about the processing chamber, intermediate the processing chamber and the cable segment, and is symmetrically dimensioned about the axis. The outer enclosure is rotatably coupled to the processing chamber and it rotates at one-half the speed of the processing chamber.

摘要翻译： 处理室相对于固定基座可旋转地安装的离心处理装置。 脐带缆段在其一侧基本上沿着处理室的轴线固定在一端，电缆段的另一端基本上被附接在轴线上，以与处理室旋转锁定接合。 外壳围绕处理室定位，位于处理室和电缆段之间，并且围绕轴对称地定尺寸。 外壳可旋转地联接到处理室，并以处理室的一半速度旋转。

公开(公告)号：US4109852A

公开(公告)日：1978-08-29

申请号：US844225

申请日：1977-10-21

申请人： Richard I. Brown ,  Daniel R. Boggs

发明人： Richard I. Brown ,  Daniel R. Boggs

IPC分类号： B04B5/04 ,  B04B5/02

CPC分类号： B04B5/0442 ,  B04B2005/0492

摘要： Centrifugal processing apparatus in which a processing chamber is rotatably mounted with respect to a stationary base. An umbilical cable segment is fixed at one end substantially along the axis of the processing chamber at one side thereof, with the other end of the cable segment being attached substantially on the axis in rotationally locked engagement to the processing chamber. A flexible sheath member is carried by the umbilical cable segment with the flexible sheath member being connected to the axis and having a shank portion which extends from the axis and along a portion of the cable segment. The shank portion of the flexible sheath member has a thickness which decreases along the cable segment in the direction away from the axis. The flexible sheath member provides the umbilical cable segment with a localized stiffness at its anchor points sufficient to allow the umbilical cable segment to withstand high centrifugal forces without fracturing and without requiring other means of lateral support.

摘要翻译： 处理室相对于固定基座可旋转地安装的离心处理装置。 脐带缆段在其一侧基本上沿着处理室的轴线固定在一端，电缆段的另一端基本上被附接在轴线上，以与处理室旋转锁定接合。 柔性护套构件由脐带缆段承载，柔性护套构件连接到轴线并且具有从轴线延伸并且沿着电缆段的一部分延伸的柄部分。 柔性护套部件的柄部分具有沿远离轴线的方向沿电缆段减小的厚度。 柔性护套构件在其锚固点处提供脐带缆段具有足够的局部刚度，以足以允许脐带缆段承受高离心力而不破裂，而不需要其他横向支撑装置。

公开(公告)号：US09603989B2

公开(公告)日：2017-03-28

申请号：US12861974

申请日：2010-08-24

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： A61M1/36 ,  A61M1/02

CPC分类号： A61M1/0272 ,  A61M1/02 ,  A61M1/3621 ,  A61M1/3672 ,  A61M2205/3334 ,  A61M2205/52 ,  H05K999/99

摘要： Methods are provided for anticoagulating blood. Whole blood is drawn from a donor into a system at a draw flow rate. Anticoagulant from an anticoagulant source is pumped into the system at an anticoagulant flow rate to mix with the blood. The anticoagulated blood may be subsequently processed in any of a number of known ways, including separating it and removing at least a portion of one of the components of the blood. Thereafter, at least a portion of the remaining blood may be returned to the donor. The anticoagulant flow rate is independent of the draw flow rate and can be based on a number of factors, including the weight of the donor and the rate at which the donor can metabolize the anticoagulant.

公开(公告)号：US20120053501A1

公开(公告)日：2012-03-01

申请号：US12861974

申请日：2010-08-24

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： A61M1/36

CPC分类号： A61M1/0272 ,  A61M1/02 ,  A61M1/3621 ,  A61M1/3672 ,  A61M2205/3334 ,  A61M2205/52 ,  H05K999/99

摘要： Methods and systems are provided for anticoagulating blood. Whole blood is drawn from a donor into a system at a draw flow rate. Anticoagulant from an anticoagulant source is pumped into the system at an anticoagulant flow rate to mix with the blood. The anticoagulated blood may be subsequently processed in any of a number of known ways, including separating it and removing at least a portion of one of the components of the blood. Thereafter, at least a portion of the remaining blood may be returned to the donor. The anticoagulant flow rate is independent of the draw flow rate and can be based on a number of factors, including the weight of the donor and the rate at which the donor can metabolize the anticoagulant.

摘要翻译： 提供用于抗凝血的方法和系统。 将全血从供体抽出到抽吸流量的系统中。 来自抗凝血剂来源的抗凝血剂以抗凝血流量泵入系统以与血液混合。 随后可以以许多已知方式中的任何一种处理抗凝血液，包括分离血浆并除去血液中一种成分的至少一部分。 此后，剩余血液的至少一部分可以返回给供体。 抗凝血剂流速与抽吸流速无关，可以基于许多因素，包括供体的重量和供体可以代谢抗凝血剂的速率。

公开(公告)号：US07918350B2

公开(公告)日：2011-04-05

申请号：US12399545

申请日：2009-03-06

申请人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

IPC分类号： B04B3/00 ,  B04B1/06 ,  B04B1/12 ,  B04B7/10 ,  B01D21/26 ,  B01D45/12

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

摘要翻译： 使用分离装置和方法来使用用于围绕轴线旋转的分离通道。 这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。 入口将流体输送到通道中。 屏障位于内外侧壁部分的通道中间。 第一流动路径在屏障的上游侧和下游侧之间连通。 收集区域可以位于屏障的下游，用于与第一流动路径通信。 通道的外侧壁部分可以位于其上游部分的径向外侧。 屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。 第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

公开(公告)号：US06849039B2

公开(公告)日：2005-02-01

申请号：US10279765

申请日：2002-10-24

申请人： Kyungyoon Min ,  Richard I. Brown ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Julie Moriarty

IPC分类号： A61M1/36 ,  A61M1/38 ,  B04B5/04 ,  B01D21/26 ,  B04B11/00

CPC分类号： A61M1/3693 ,  A61M1/3633 ,  A61M1/3696 ,  A61M1/38 ,  A61M2202/0429 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.

摘要翻译： 血液分离系统和方法将血液引入低G壁和高G壁之间的环形分离通道，同时围绕轴线旋转分离通道，以将血液分离成血液成分。 环形分隔通道具有环形边界壁。 系统和方法将第一血液成分引导到沿着低G壁的收缩通道。 系统和方法通过与分离通道连通的第一路径去除第一血液成分，所述第一路径通过邻近靠近低G壁的收缩通道的开口。 系统和方法沿着沿着高G壁的轴向方向朝着环形边界壁延伸的表面引导第二血液成分。 所述系统和方法通过第二路径收集第二血液成分，所述第二路径通过与所述环形边界壁轴向间隔开的邻近所述高G壁的表面邻接的开口与所述分离通道连通。

公开(公告)号：US06207063B1

公开(公告)日：2001-03-27

申请号：US09527148

申请日：2000-03-16

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： B01D1712

CPC分类号： A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/385 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  A61M2202/0071 ,  A61M2202/0092

摘要： Blood processing systems and methods separate whole blood into red blood cells and a plasma constituent within a rotating centrifugal separation device. The systems and methods convey whole blood into the separation device through an inlet path including a pump operable at a prescribed rate. The systems and methods remove plasma constituent from the separation device through an outlet path including a pump operable at a prescribed rate. The systems and methods derive a value Hb representing an apparent hematocrit of whole blood entering the separation device, where: H b = H rbc ⁡ ( Q b - Q p ) Q b and where Hrbc is a value relating to hematocrit of red blood cells in the separation device. The systems and methods generate outputs and control commands based, at least in part, upon Hb.

摘要翻译： 血液处理系统和方法将全血分离成红细胞和旋转离心分离装置内的等离子体成分。 系统和方法通过包括可以规定速率操作的泵的入口路径将全血输送到分离装置中。 系统和方法通过包括以规定速率操作的泵的出口路径从分离装置中除去等离子体成分。 系统和方法导出表示进入分离装置的全血的明显血细胞比容的值Hb，其中：Hrbc是与分离装置中红细胞的血细胞比容有关的值。 系统和方法至少部分地基于Hb生成输出和控制命令。

公开(公告)号：US06197202B1

公开(公告)日：2001-03-06

申请号：US09027638

申请日：1998-02-23

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： B01D1712

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/0209 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0092

摘要： Systems and methods separate platelets from a selected donor. The systems and methods convey anticoagulated blood containing plasma and platelets from the selected donor into the separation device for separating into a plasma yield and a platelet yield. The systems and methods estimate, at least in part while separation occurs, a count of platelets (PltCirc) available for collection from the selected donor by measuring the selected donor's platelet precount (Pltpre), estimating a dilution factor caused by addition of anticoagulant (Dilution), and estimating a depletion factor (Depletion) caused by removal of available platelets during blood processing. In estimating Depletion, the systems and methods take into account a splenic mobilization function (Spleen), which is derived from a population of donors and not specific to the selected donor, where Spleen comprises a function of PltPRE.

摘要翻译： 系统和方法将血小板与选定的供体分开。 系统和方法将含有血浆和血小板的抗凝血从所选供体输送到分离装置中，以分离成血浆产量和血小板产量。 系统和方法至少部分地估计，通过测量选定的供体的血小板计数（Pltpre），估计通过加入抗凝血剂引起的稀释因子（稀释），计算可从选定供体中收集的血小板（PltCirc）数量 ），并估计在血液处理期间除去可用血小板引起的耗竭因子（耗尽）。 在估计消耗时，系统和方法考虑到脾运动功能（脾），其来源于供体群体，并且不是特定于所选择的供体，其中脾脏包含PltPRE的功能。

公开(公告)号：US5980760A

公开(公告)日：1999-11-09

申请号：US886780

申请日：1997-07-01

申请人： Kyungyoon Min ,  Richard I Brown ,  Daniel F Bischof ,  William H Cork ,  Robert J Cantu

发明人： Kyungyoon Min ,  Richard I Brown ,  Daniel F Bischof ,  William H Cork ,  Robert J Cantu

IPC分类号： A61M1/02 ,  A61M1/36 ,  B01D21/26 ,  B04B5/04 ,  B04B11/02 ,  B04B13/00

CPC分类号： B01D21/302 ,  A61M1/3696 ,  B01D21/262 ,  B04B13/00 ,  B04B5/0442 ,  B01D2221/10 ,  B04B2005/045

摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.

摘要翻译： 血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面， 和等离子体成分。 该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。 该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。 出口路径从腔室传送去除的界面。 出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。