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公开(公告)号:US20210295958A1
公开(公告)日:2021-09-23
申请号:US17201393
申请日:2021-03-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Stephen Martin , Alexandra Paun , Jakub Winiarz
IPC: G16H10/40 , G16H10/20 , G06F16/2457 , G06F16/28
Abstract: A method for operating a data processing agent for processing data from an automated medical sample analyzer is presented. The method comprises receiving at least one automated analyzer status datum transmitted from at least one automated analyzers in a medical sample analysis system to the data processing agent, wherein the automated analyzer status data is generated by the at least one automated analyzer in response to an automated analyzer condition detected by an automated analyzer, receiving at least one annotation datum at the data processing agent, associating at least one automated analyzer status datum with at least one annotation datum using the processing agent to generate an automated analyzer system data record, and outputting the automated analyzer system data record from the data processing agent, wherein the automated analyzer system data record comprises at least one automated analyzer device status datum associated with at least one annotation datum.
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公开(公告)号:US11125695B2
公开(公告)日:2021-09-21
申请号:US16111646
申请日:2018-08-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Hans-Peter Josel , Herbert Andres , Michaela Windfuhr , Oliver Larbolette , Stefan Quint
IPC: G01N21/76 , G01N21/66 , G01N33/543 , C07F15/00 , G01N27/30
Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
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公开(公告)号:US11125601B2
公开(公告)日:2021-09-21
申请号:US16226889
申请日:2018-12-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Guenter Ziegler , Oliver Larbolette , Rolf Herb
IPC: G01F23/292 , G01F23/14 , G01F23/24 , G01F23/26 , G01N35/10
Abstract: An apparatus for processing a laboratory sample contained in a laboratory sample container is presented. The apparatus comprises an optical sensing unit for sensing a transmittance at different vertical positions through the laboratory sample container and a tip sensing unit having a tip. The tip sensing unit is adapted to provide a tip sensing signal (tLDS) depending on a position of the tip relative to the sample. The apparatus also comprises a process control unit adapted to control the secure and reliable pipetting of the laboratory sample in response to both the transmittance and the tip sensing signal (tLDS) provided by the tip sensing unit.
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公开(公告)号:US20210287370A1
公开(公告)日:2021-09-16
申请号:US17197655
申请日:2021-03-10
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Emad Sarofim
Abstract: A method for determining sample container characteristics is presented. The method comprises providing first image data representing a first image of a sample container in a first scenario, wherein in the first scenario, a first illumination condition comprising a sample container background illumination is applied to the sample container; providing second image data representing a second image of the sample container in a second scenario, wherein in the second scenario, a second illumination condition different from the first is applied to the sample container; determining a mask from the first image that indicates a sub-image section of the first image comprising a sample container representation in the first image; determining sub-image data from the second image containing a sample container representation in the second image by applying the mask to the second image; and determining the sample container characteristics from an image data analysis comprising image sub-image data data analysis.
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公开(公告)号:US11099154B2
公开(公告)日:2021-08-24
申请号:US15366695
申请日:2016-12-01
Inventor: Uwe Kobold , Roland Thiele , Noah Weiss , Lauren Brown
IPC: G01N27/624 , G01N33/82 , G01N33/487 , H01J49/00
Abstract: A method of quantifying the amount of at least two analytes A1 and A2 involving (a) adding at least one salt (S) to at least a portion (P1) of the sample comprising the at least two analytes A1 and A2, (b) ionizing at least a portion of the sample according to (a) thereby forming an analyte flow comprising the analytes A1 and A2 in ionized form, (c) separating the ionized analytes A1 and A2 from each other by using at least one ion mobility separator (124), wherein the analyte flow according to (b) at least partially passes through the ion mobility separator (124), and (d) quantifying the amount of the separated ionized analytes obtained according to (c), wherein A1 is a pharmaceutically active compound C or derivative thereof and A2 is a metabolite or stereoisomer of C.
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公开(公告)号:US20210231641A1
公开(公告)日:2021-07-29
申请号:US17231065
申请日:2021-04-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Michael Rein
Abstract: A method for determining properties of a laboratory sample contained in a laboratory sample container is presented. The method comprises measuring projections of the laboratory sample container comprising the laboratory sample by irradiating light to the laboratory sample container at different projection angle and determining the properties by tomographic reconstruction based on the projections.
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公开(公告)号:US20210215716A1
公开(公告)日:2021-07-15
申请号:US17181386
申请日:2021-02-22
Applicant: Roche Diagnostics Operations, Inc. , Universiteit Maastricht , Academisch Ziekenhuis Maastricht
Inventor: Peter Kastner , Manuel Dietrich , André Ziegler , Ursula-Henrike Wienhues-Thelen , Vinzent Rolny , Ulrich Schotten
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of SPON-1 in a sample from the subject, and comparing the amount of SPON-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of SPON-1.
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98.
公开(公告)号:US20210206793A1
公开(公告)日:2021-07-08
申请号:US17055101
申请日:2019-05-17
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor: Urs SPITZ , Günter SCHABERT , Aysel SOYDEMIR , Lukas WICK
IPC: C07H1/06 , C07H19/048
Abstract: The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.
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公开(公告)号:US11047866B2
公开(公告)日:2021-06-29
申请号:US16420385
申请日:2019-05-23
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Johann Karl , Ursula-Henrike Wienhues-Thelen , Dirk Block , Christian Zaugg , Hans-Peter Brunner , James Januzzi , Andre Ziegler , Julian Braz , Thomas Dieterle , Edelgard Kaiser
Abstract: Presented is a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method involves measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Further envisaged is a method of monitoring diastolic function in a patient suffering from heart failure. Also described are kits and devices adapted to carry out the method.
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100.
公开(公告)号:US20210190801A1
公开(公告)日:2021-06-24
申请号:US17177673
申请日:2021-02-17
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC. , UNIVERSITEIT MAASTRICHT , ACADEMISCH ZIEKENHUIS MAASTRICT
Inventor: Johann Karl , Peter Kastner , Ursula-Henrike Wienhues-Thelen , Manuel Dietrich , Andre Ziegler , Ulrich Schotten
IPC: G01N33/68 , G01N33/577
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of BMP 10 in a sample from the subject, and comparing the amount of BMP 10 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure based on the determination of BMP 10 in a sample from a subject. Further, the present invention relates to a method for predicting the risk of a subject of hospitalization due to heart failure based on the determination of a BMP 10-type peptide in a sample from a subject.
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