公开(公告)号：US10047068B2

公开(公告)日：2018-08-14

申请号：US15312788

申请日：2015-05-21

Applicant: Shiseido Company, Ltd

Inventor： Yosuke Tojo ,  Masashi Mita ,  Wolfgang Lindner

IPC: C07D401/04

Abstract: The problem addressed by the present invention is to provide a novel method for separating and purifying pure enantiomer of lenalidomide. Pure enantiomer of lenalidomide can be separated and purified by using, as the mobile phase, an organic solvent selected from the group consisting of aprotic solvents, secondary alcohols, and mixtures thereof.

公开(公告)号：US09968542B2

公开(公告)日：2018-05-15

申请号：US14434249

申请日：2013-10-11

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Takahiro Kishina ,  Katsuyuki Kaneko ,  Amane Tatsuta ,  Yukiko Sato ,  Minako Shudo ,  Masahiko Yamaguchi ,  Hiroyo Usuki ,  Mikino Nosaka ,  Nozomi Takeshita

IPC: A61K8/81 ,  A61K8/60 ,  A61K8/86 ,  A61K8/34 ,  A61Q1/02 ,  A61Q1/14 ,  A61K8/06

CPC classification number: A61K8/8135 ,  A61K8/062 ,  A61K8/345 ,  A61K8/60 ,  A61K8/86 ,  A61K2800/59 ,  A61Q1/02 ,  A61Q1/14

Abstract: A makeup base for skin that is applied to the skin before applying a makeup cosmetic is provided. The makeup base is not smeared or removed by sweat or cold water, but, when rubbed with warm water, is easily removed from the skin together with the makeup cosmetic and without using a cosmetic cleanser. The makeup base includes a water-containing aqueous phase as a continuous phase, which includes (a) a vinyl acetate polymer, (b) polyhydric alcohol, and (c) a hydrophilic nonionic surfactant. The (a) the vinyl acetate polymer is 0.5 to 7 mass % in the makeup base and is dispersed as particles in the aqueous phase, (b) the polyhydric alcohol is 0.5 to 5.5 parts by mass relative to 1 part by mass of (a) the vinyl acetate polymer, and (c) the hydrophilic nonionic surfactant is 1 to 5 mass % in the makeup base.

公开(公告)号：US20170239165A1

公开(公告)日：2017-08-24

申请号：US15501989

申请日：2015-06-30

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yuki SUGIYAMA ,  Hirohito SHIRAKAMI ,  Kazuyuki MIYAZAWA

IPC: A61K8/81 ,  A61K8/31 ,  A61K8/36 ,  A61K8/34 ,  A61Q1/00 ,  A61Q19/02 ,  A61Q19/00 ,  A61Q19/10 ,  A61Q17/04 ,  A61Q5/06 ,  A61K8/06 ,  A61K8/58

CPC classification number: A61K8/8152 ,  A61K8/042 ,  A61K8/062 ,  A61K8/31 ,  A61K8/342 ,  A61K8/345 ,  A61K8/361 ,  A61K8/585 ,  A61K8/86 ,  A61K2800/30 ,  A61K2800/412 ,  A61K2800/54 ,  A61Q1/00 ,  A61Q5/06 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/10

Abstract: A starting (raw) material, for cosmetics, comprising a core corona type microgel dispersion obtained by radical polymerization of a specific polyethylene oxide macromonomer, a specific hydrophobic monomer, and a specific cross-linking monomer under specific conditions. The purpose of the present invention is to provide the raw material for cosmetics, with which the cosmetic having a high stability provides a good feeling in use and does not cause skin irritation, can be easily produced.

公开(公告)号：US20170192024A1

公开(公告)日：2017-07-06

申请号：US15312777

申请日：2015-05-21

Applicant: Shiseido Company, Ltd

Inventor： Yosuke TOJO ,  Masashi MITA ,  Wolfgang Lindner

IPC: G01N33/94 ,  B01D15/12 ,  B01D15/26 ,  B01D15/16

Abstract: The present invention addresses the problem of providing a novel method for the pretreatment of a biological sample containing lenalidomide enantiomer and thereby establishing a simple and accurate method for the quantitative analysis of lenalidomide enantiomer. In the present invention, the racemization and decomposition of lenalidomide enantiomer in a biological sample can be prevented by the deproteinization under acidic conditions of the biological sample containing lenalidomide enantiomer, and the lenalidomide enantiomer can be simply and accurately quantitatively analyzed by subjecting to HPLC the biological sample that has been pretreated in such a way.

公开(公告)号：US09572763B2

公开(公告)日：2017-02-21

申请号：US14438793

申请日：2013-10-28

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Tomoko Ikeda

IPC: A61K8/64 ,  A61K8/891 ,  A61K8/31 ,  A61Q1/02 ,  A61Q1/10 ,  A61K8/37 ,  A61K8/58 ,  A61K8/06 ,  A61Q5/06 ,  A61K8/894 ,  A61Q1/04

CPC classification number: A61K8/891 ,  A61K8/06 ,  A61K8/064 ,  A61K8/31 ,  A61K8/37 ,  A61K8/375 ,  A61K8/585 ,  A61K8/894 ,  A61K2800/52 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q5/06 ,  A61Q5/065

Abstract: To provide a water-in-oil emulsion composition having a high stability and which provides fresh feeling in use and glossy finish. The water-in-oil emulsion composition of the present invention is characterized by comprising: (a) 1 to 20 mass % of a polyhydric alcohol fatty acid ester and/or a hydrocarbon; (b) 3 to 20 mass % of a transparent non-volatile silicone oil that separates when mixed with component (a) at 25° C.; (c) 0.1 to 5 mass % of zinc decyl trisiloxanecarboxylate; and (d) water.

Abstract translation: 提供具有高稳定性的油包水乳液组合物，其提供使用中的清新感和光泽。 本发明的油包水乳液组合物的特征在于：（a）1〜20质量％的多元醇脂肪酸酯和/或烃; （b）3〜20质量％在25℃下与（a）成分混合时分离的透明非挥发性硅油。 （c）0.1〜5质量％的癸基三硅氧烷羧酸锌; 和（d）水。

公开(公告)号：US20170014444A1

公开(公告)日：2017-01-19

申请号：US15124767

申请日：2014-03-12

Applicant: Shiseido Company, Ltd

Inventor： Junichi HOSOI ,  Kaori INOUE ,  Shoko YAMADA ,  Minako SATO

IPC: A61K31/716 ,  A61K36/738 ,  A61K31/77

CPC classification number: A61K31/716 ,  A61K31/77 ,  A61K36/738 ,  A61K2300/00

Abstract: An object of the present invention is to provide an agent for sedating the response of skin to external stimulation. The aforementioned object was achieved by finding a component that promotes CD39 gene expression in Langerhans cells. More specifically, the present invention is based on the finding that the combination of carboxymethyl-beta glucan or a salt thereof polyoxyethylene (POE)/polyoxypropylene (POP) random copolymer dimethyl ether and rosewater promotes CD39 gene expression.

Abstract translation: 本发明的目的是提供一种用于镇静皮肤对外部刺激的反应的药剂。 上述目的是通过在朗格汉斯细胞中发现促进CD39基因表达的成分来实现的。 更具体地，本发明是基于以下发现：羧甲基β葡聚糖或其盐的聚氧乙烯（POE）/聚氧丙烯（POP）无规共聚物二甲醚和rosewater的组合促进CD39基因表达。

公开(公告)号：US09532981B2

公开(公告)日：2017-01-03

申请号：US14496534

申请日：2014-09-25

Applicant: Shiseido Company, Ltd.

Inventor： Shunsuke Iriyama ,  Kenichi Umishio ,  Makoto Tsunenaga ,  Shinji Inomata ,  Eijiro Adachi

IPC: A61F2/10 ,  C12N5/071 ,  A61L27/60 ,  A61K31/4406 ,  A61L27/38 ,  A61K31/4184 ,  A61L27/36

Abstract: The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.

公开(公告)号：US20160250131A1

公开(公告)日：2016-09-01

申请号：US15028134

申请日：2013-10-09

Applicant: SHISEIDO COMPANY, LTD.

Inventor： ATSUSHI SOGABE ,  Ayano MATSUO ,  Shin-Ichi YUSA

IPC: A61K8/81 ,  C08F8/44 ,  C08F120/58 ,  A61Q19/00

CPC classification number: A61K8/8147 ,  A61K8/8152 ,  A61K8/8158 ,  A61K2800/10 ,  A61K2800/48 ,  A61Q19/00 ,  C08F8/44 ,  C08F120/06 ,  C08F120/58

Abstract: The present invention was aimed to provide a low-stringiness thickener consisting of a compound in high demand as a thickener for cosmetics, i.e., polyacrylic acid or a salt thereof, or PAMPS or a salt thereof, where a stringiness property of the compound was reduced.A low-stringiness thickener consisting of a compound selected from polyacrylic acid. a salt of polyacrylic acid, PAMPS, and a salt of PAMPS, wherein the weight-average molecular weight of the compound is 500 thousand to 8 million, and wherein the content of the compound having the molecular weight of 10 million or higher is 10 mass % or less.

Abstract translation: 本发明的目的在于提供一种低密度增稠剂，其由化合物的增稠剂，即聚丙烯酸或其盐或PAMPS或其盐的高需求化合物组成，其中化合物的丝状性降低 。 由选自聚丙烯酸的化合物组成的低强度增稠剂。 聚丙烯酸盐，PAMPS和PAMPS的盐，其中化合物的重均分子量为50万至800万，其中分子量为1000万或更高的化合物的含量为10质量％ ％ 或更少。

公开(公告)号：US20160220457A1

公开(公告)日：2016-08-04

申请号：US15021729

申请日：2014-12-02

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Kazuhiro YAMAGUCHI ,  Mayuri TASHIRO ,  Kazutaka SASAKI

IPC: A61K8/19 ,  A61K8/06 ,  A61K8/34 ,  A61K8/02 ,  A61K8/29 ,  A61K8/27 ,  A61K8/89 ,  A61Q17/04 ,  A61Q1/02

CPC classification number: A61K8/19 ,  A61K8/0241 ,  A61K8/025 ,  A61K8/064 ,  A61K8/27 ,  A61K8/29 ,  A61K8/345 ,  A61K8/89 ,  A61K2800/21 ,  A61K2800/30 ,  A61K2800/413 ,  A61Q1/02 ,  A61Q17/04

Abstract: The present invention provides a water-in-oil emulsified sunscreen cosmetic comprising the following ingredients (a), (b), (c), and (d) in the outer phase and not comprising octylmethoxy cinnamate, octocrylene, or avobenzone.(a) 5-15 wt % of hydrophobized rutile type crystallized titanium dioxide having an average particle size of 30-80 nm, (b) 0.1-10 wt % of iron oxide, (c) 5-15 wt % of hydrophobized zinc oxide having an average particle size of 20-80 nm, (d) 0-1.0 wt % of titanium dioxide for white pigment having an average particle size of 180 nm or more. The object of the present invention is to provide a water-in-oil emulsified sunscreen cosmetic that is applied on the face including the areas surrounding the eyes, wherein irritation to the eyes is minor, the UVB and UVA protection effect is high, and a superior makeup effect is also manifested.

Abstract translation: 本发明提供一种油包水乳化防晒化妆品，其包含在外相中的以下成分（a），（b），（c）和（d），不包括辛基甲氧基肉桂酸酯，辛烯腈或阿伏苯宗。 （a）5-15重量％的平均粒度为30-80nm的疏水化金红石型结晶二氧化钛，（b）0.1-10重量％的氧化铁，（c）5-15重量％的疏水化氧化锌 平均粒径为20-80nm，（d）0-1.0重量％的平均粒径为180nm以上的白色颜料的二氧化钛。 本发明的目的是提供一种油包水型乳化防晒化妆品，其涂布在包括眼睛周围区域的面部上，对眼睛的刺激较小，UVB和UVA保护效果高， 优秀的化妆效果也体现出来。

公开(公告)号：US20160069867A1

公开(公告)日：2016-03-10

申请号：US14477213

申请日：2014-09-04

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yosuke Tojo ,  Masato lino ,  Chieko Mizumoto ,  Yuzo Yoshida ,  Hisashi Mori

IPC: G01N33/50 ,  A61K36/28 ,  A61K36/9068 ,  C12Q1/68 ,  A61K38/01

CPC classification number: C12Q1/6876 ,  A61K8/645 ,  A61K8/97 ,  A61K36/28 ,  A61K36/899 ,  A61K36/9068 ,  A61K38/011 ,  A61K2800/782 ,  A61Q19/00 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N33/6812 ,  G01N2333/968 ,  G01N2333/99 ,  G01N2800/20 ,  A61K2300/00

Abstract: The object of the invention is to develop a screening method for drugs having effects of increasing skin barrier function in in vitro experimentation, and to evaluate skin barrier function for skin. Serine racemase activity and/or expression level are used as an indicator to allow screening of candidate drugs.

Abstract translation: 本发明的目的是开发一种在体外实验中具有增加皮肤屏障功能作用的药物的筛选方法，并评估皮肤的皮肤屏障功能。 使用丝氨酸消旋酶活性和/或表达水平作为候选药物筛选的指标。