公开(公告)号：US10702664B2

公开(公告)日：2020-07-07

申请号：US15676705

申请日：2017-08-14

Applicant: STC.UNM

Inventor： Nicola Jeanne Maynard ,  Hugh D. C. Smyth

IPC: A61M15/00 ,  A61M11/00 ,  A61M16/00

Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

公开(公告)号：US20200212198A1

公开(公告)日：2020-07-02

申请号：US16746853

申请日：2020-01-18

Applicant: STC.UNM

Inventor： Steven R.J. Brueck ,  Stephen D. Hersee ,  Seung-Chang Lee ,  Daniel Feezell

IPC: H01L29/66 ,  H01L29/06 ,  B82Y40/00 ,  H01L21/02 ,  H01L29/78 ,  H01L29/16 ,  H01L29/775 ,  B82Y10/00 ,  H01L29/04 ,  H01L29/778 ,  H01L29/20

Abstract: A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.

公开(公告)号：US20200161126A1

公开(公告)日：2020-05-21

申请号：US16684313

申请日：2019-11-14

Applicant: STC.UNM

Inventor： Morteza MONAVARIAN ,  Daniel FEEZELL ,  Andrew ARAGON ,  Saadat MISHKAT-UL-MASABIH ,  Andrew ALLERMAN ,  Andrew ARMSTRONG ,  Mary CRAWFORD

IPC: H01L21/02 ,  H01L21/3065 ,  H01L21/306

Abstract: A method comprises providing a substrate comprising an n-type Al/In/GaN semiconductor material. A surface of the substrate is dry-etched to form a trench therein and cause dry-etch damage to remain on the surface. The surface of the substrate is immersed in an electrolyte solution and illuminated with above bandgap light having a wavelength that generates electron-hole pairs in the n-type Al/In/GaN semiconductor material, thereby photoelectrochemically etching the surface to remove at least a portion of the dry-etch damage.

公开(公告)号：US10605705B2

公开(公告)日：2020-03-31

申请号：US15950979

申请日：2018-04-11

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Bryan J. Kaehr ,  C. Jeffrey Brinker ,  Jason L. Townson

IPC: G01N1/28 ,  C08K3/36 ,  C12N11/14

Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

公开(公告)号：US10583099B2

公开(公告)日：2020-03-10

申请号：US16412017

申请日：2019-05-14

Applicant: STC.UNM

Inventor： Graham Timmins ,  Vojo P. Deretic

IPC: A61K31/137 ,  A61P11/00 ,  A61P31/06 ,  A61K31/136 ,  A61K35/00 ,  A61K51/04 ,  C07C213/08 ,  A61K31/395 ,  A61K9/00 ,  C07C215/42 ,  C07B59/00 ,  A61P31/04 ,  C07C215/68 ,  A61K45/06 ,  A61K45/00

Abstract: The present invention is directed to 2H isotope enhanced ambroxol (“isotope enhanced ambroxol”) and its use in the treatment of autophagy infections, especially mycobacterial and other infections, disease states and/or conditions of the lung, such as tuberculosis, especially including drug resistant and multiple drug resistant tuberculosis. Pharmaceutical compositions comprising isotope enhanced ambroxol, alone or in combination with an additional bioactive agent, especially rifamycin antibiotics, including an additional autophagy modulator (an agent which is active to promote or inhibit autophagy) are also disclosed. These compositions are useful against an autophagy mediated disease state and/or condition), especially an autophagy mediated disease state and/or condition which occurs in the lungs.

公开(公告)号：US20200056232A1

公开(公告)日：2020-02-20

申请号：US16401311

申请日：2019-05-02

Applicant: STC.UNM

Inventor： Jeremy Scott Edwards

IPC: C12Q1/6874 ,  C12Q1/6841 ,  C12Q1/6825

Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

公开(公告)号：US10514215B2

公开(公告)日：2019-12-24

申请号：US15768829

申请日：2016-10-17

Applicant: STC.UNM

Inventor： Sang Eon Han ,  Sang M. Han

IPC: F28F13/18 ,  F24S70/20 ,  F25B23/00

Abstract: The present prevention provides a surface coating for cooling a surface by light scattering comprising a plurality of successive layers, each of the layers may be comprised of a plurality of spheres arranged to form a structure comprised of packed spheres. Each layer may have a different arrangement of packed spheres to create to a different light scattering property in each of the layers. The coating of the structures may also be formed by randomly packed spheres and the spheres may have a uniform diameter.

公开(公告)号：US10453996B2

公开(公告)日：2019-10-22

申请号：US15374547

申请日：2016-12-09

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Seung-Chang Lee ,  Christian Wetzel ,  Mark Durniak

IPC: H01L29/778 ,  H01L33/32 ,  H01L21/02 ,  H01L21/78 ,  H01L33/00 ,  H01L33/04 ,  H01L33/18 ,  H01L29/04

Abstract: A method of forming a semiconductor structure includes providing a substrate comprising a first material portion and a single crystal silicon layer on the first material portion. The substrate further comprises a major front surface, a major backside surface opposing the major front surface, and a plurality of grooves positioned in the major front surface. A buffer layer is deposited in one or more of the plurality of grooves. A semiconductor material is epitaxially grown over the buffer layer and in the one or more plurality of grooves, the epitaxially grown semiconductor material comprising a hexagonal crystalline phase layer and a cubic crystalline phase structure disposed over the hexagonal crystalline phase.

公开(公告)号：US20190298222A1

公开(公告)日：2019-10-03

申请号：US16467275

申请日：2017-12-07

Applicant: STC.UNM

Inventor： Sang M. HAN ,  Jarred Caldwell ,  Nicholas BRECHTEL ,  Nathan MADRID ,  Divya PRAKASH

IPC: A61B5/06 ,  A61B5/00 ,  A61J15/00

Abstract: An apparatus for determining a position of an object inside a body includes a first detector configured to receive a signal from the object inside the body. The apparatus also includes a camera configured to capture an image or video of outside of a portion of the body. The object is positioned inside the portion of the body. A connoting system is configured to receive the signal from the first detector and the image or video from the camera and to determine the position of the object inside the body. A screen is configured to display die position of the object inside the body.

公开(公告)号：US10411436B2

公开(公告)日：2019-09-10

申请号：US15571800

申请日：2016-05-06

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Sanjay Krishna ,  Daniel P. Dapkus

IPC: H01S5/00 ,  H01S5/12 ,  H01S5/042 ,  H01S5/026 ,  H01S5/02 ,  H01S5/022 ,  H01S5/04 ,  H01S5/40 ,  H01S3/13 ,  H01S5/50 ,  H01S5/343 ,  G01N21/17 ,  G01N21/39

Abstract: A tunable laser device includes a laser structure and a plurality of individually addressable, separated contact stripes disposed on the laser structure. The laser structure includes a substrate, an active portion disposed on the substrate, and a chirped distributed feedback (DFB) grating disposed on the active portion. The active portion includes at least top and bottom contact layers and a gain medium.