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公开(公告)号:US09309392B2
公开(公告)日:2016-04-12
申请号:US14335867
申请日:2014-07-18
Applicant: QATAR UNIVERSITY , THE UNIVERSITY OF SHEFFIELD , Azza Mohamed Ahmed Helal
Inventor: Mariam Alali Almaadeed , Nabil Madi , Alma Hodzic , Saravanan Rajendran
CPC classification number: C08L23/06 , C08K3/34 , C08K7/02 , C08L23/10 , C08L2205/025 , C08L2205/03 , C08L2207/062 , C08L2207/066 , C08L2207/20
Abstract: The reinforced polymer composites from recycled plastic are polymer blends made from recycled polymers that are reinforced with glass fibers and mica. In particular, the reinforced polymer composites are blends of recycled low-density polyethylene (LDPE), high-density polyethylene (HDPE), and polypropylene (PP) with a mica filler that are reinforced with glass fibers, where the low-density polyethylene forms between 30 wt % and 35 wt % of the composite, the high-density polyethylene forms between 15 wt % and 17.5 wt % of the composite, the polypropylene forms between 15 wt % and 17.5 wt % of the composite, the glass fibers form between 15 wt % and 40 wt % of the composite, and the mica forms up to 15 wt % of the structural element. The resultant reinforced polymer composite has a relatively high heat deflection temperature, good mechanical properties (such as increased stiffness and strength), improved thermal stability, and is cost effective to manufacture.
Abstract translation: 来自再生塑料的增强聚合物复合材料是由玻璃纤维和云母增强的再循环聚合物制成的聚合物共混物。 特别地,增强聚合物复合材料是再生低密度聚乙烯(LDPE),高密度聚乙烯(HDPE)和聚丙烯(PP)与玻璃纤维增强的云母填料的混合物,其中低密度聚乙烯形成 在复合材料的30重量%至35重量%之间,高密度聚乙烯形成复合材料的15重量%至17.5重量%之间,聚丙烯形成复合材料的15重量%至17.5重量%之间,玻璃纤维之间形成 15重量%和40重量%的复合材料,并且云母形成至多15重量%的结构元件。 所得的增强聚合物复合材料具有相对较高的热变形温度,良好的机械性能(例如增加的刚度和强度),改善的热稳定性,并且制造成本有效。
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公开(公告)号:US20160039852A1
公开(公告)日:2016-02-11
申请号:US14781661
申请日:2014-04-01
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Robert Graham-Goodwin Russell , Ilaria Bellantuono
IPC: C07F9/6506 , A61Q17/04 , A61K8/55 , A61K45/06 , C07F9/6561 , A61K31/675
CPC classification number: C07F9/6506 , A61K8/55 , A61K31/663 , A61K31/675 , A61K45/06 , A61Q17/04 , C07F9/3873 , C07F9/5765 , C07F9/58 , C07F9/6561 , A61K2300/00
Abstract: The invention relates to a bisphosphonate (BP) compound, or a pharmaceutically acceptable salt or solvate or prodrug thereof, for use as a cytoprotectant for protecting non-cancerous cells of a subject against radiation-induced damage and/or damage induced by a chemical agent.
Abstract translation: 本发明涉及双膦酸盐(BP)化合物或其药学上可接受的盐或溶剂合物或前药,用作保护受试者的非癌细胞免受由化学试剂引起的辐射诱发的损伤和/或损伤的细胞保护剂 。
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公开(公告)号:US20150367023A1
公开(公告)日:2015-12-24
申请号:US14758602
申请日:2013-12-20
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Cheryl MILLER , Paul V. HATTON , Felora MIRVAKILY
IPC: A61L24/12
CPC classification number: A61L24/12 , A61K6/0835 , Y10T428/2982 , C08L33/02
Abstract: A novel, glass-ionomer cement (GIC), which is preferably bioactive, and which is both trivalent metal cation-free and magnesium-free, comprising: (i) a glass composition which is both trivalent metal cation-free and magnesium-free (and is preferably bioactive), and (ii) a polyacid.
Abstract translation: 一种新颖的玻璃离子交联胶(GIC),其优选是生物活性的,并且是三价金属阳离子和无镁的,其包含:(i)玻璃组合物,其是三价金属阳离子和无镁的 (优选为生物活性),和(ii)多酸。
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公开(公告)号:US20030195366A1
公开(公告)日:2003-10-16
申请号:US10395409
申请日:2003-03-24
Applicant: The University of Sheffield
Inventor: Mauro Francesco Alessio Adamo , Varinder Kumar Aggarwal
IPC: C07D301/03
CPC classification number: C07D301/14 , C07B2200/07 , C07D301/02 , C07D303/04
Abstract: A process for the epoxidation of an alkene, which process comprises reaction of an alkene with an oxidising agent in the presence of a catalyst, characterised in that the catalyst is an amine of formula (I), wherein T represents hydrogen or a moiety of formula (a); R1, R2, R3, R4, R5 and R6 each independently represents hydrogen, optionally substituted alkyl, an optionally substituted aryl group, heterocyclyl or an optionally substituted aralkyl group wherein substituents for the above mentioned groups are selected from up to three of alkyl, aryl, heterocycyl, hydroxy, alkoxy or a group NRsRt wherein R5 and Rt each independently represents hydrogen, alkyl or alkylcarbonyl and R7 represents hydrogen, alkyl, aryl or aralkyl; or T represents a moiety (a) wherein R1 together with R2 represents an optionally substituted alkylene chain comprising 2 to 6 carbon atoms the alkylene chain being optionally interrupted with an oxygen atom or a group NRp wherein Rp is hydrogen or alkyl, and wherein optional substituents for any carbon atom of the alkylene chain are selected from hydroxy, alkoxy, oxo or a group NRsRt wherein Rs and Rt each independently represents hydrogen, alkyl or alkylcarbonyl or substituents on any two adjacent carbon atoms of the chain together with the carbon atoms to which they are attached form an alicyclic, aryl or heterocyclic ring; and R3, R4, R5, R6 and R7 are as defined above. 1
Abstract translation: 一种烯烃的环氧化方法,该方法包括在催化剂存在下烯烃与氧化剂的反应,其特征在于催化剂是式(I)的胺,其中T表示氢或式 (一个); R
1>,R 2>,R 3>,R 4>,R 5>和R 6各自独立代表氢,任选取代的烷基, 任选取代的芳基,杂环基或任选取代的芳烷基,其中上述基团的取代基选自至多三个烷基,芳基,杂环基,羟基,烷氧基或基团NR <上标> R t 其中R 5>和R t各自独立地代表氢,烷基或烷基羰基,R'上标7表示氢,烷基,芳基或芳烷基; 或T表示部分(a),其中R <上标1>与R 2>代表任选取代的包含2至6个碳原子的亚烷基链,所述亚烷基链任选地被氧原子或基团NR 上标> p>其中R p>是氢或烷基,并且其中亚烷基链的任何碳原子的任选取代基选自羟基,烷氧基,氧代或基团NR <上标> R t 其中R s>和R t各自独立地代表氢,烷基或烷基羰基或链的任何两个相邻碳原子上的取代基与它们所连接的碳原子一起形成脂环族,芳基或 杂环 R&lt;上标3&gt;,R&lt;上标4&gt;,R&lt;上标5&gt;,R&lt;上标6&gt;和R&lt;上标7&gt;如上所述。 -
公开(公告)号:US20250099486A1
公开(公告)日:2025-03-27
申请号:US18976791
申请日:2024-12-11
Inventor: Muhammad Yar , Sheila MacNeil
IPC: A61K31/565 , A61K9/70 , A61K31/7004 , A61K33/244 , A61K45/06 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L26/00 , A61P17/02
Abstract: The invention provides a D-deoxyribose sugar for use in promoting wound healing wherein the sugar is provided in a carrier and wherein the carrier is a biocompatible matrix material or a hydrogel.
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公开(公告)号:US20250025474A1
公开(公告)日:2025-01-23
申请号:US18585838
申请日:2024-02-23
Inventor: Muhammad Yar , Sheila MacNeil
IPC: A61K31/565 , A61K9/70 , A61K31/7004 , A61K33/244 , A61K45/06 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L26/00 , A61P17/02
Abstract: The invention provides a D-deoxyribose sugar for use in promoting wound healing wherein the sugar is provided in a carrier and wherein the carrier is a biocompatible matrix material or a hydrogel.
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公开(公告)号:US20240335510A1
公开(公告)日:2024-10-10
申请号:US18746819
申请日:2024-06-18
Applicant: CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES , HUMANITAS MIRASOLE SPA , The University of Sussex , King's College London , Queen Mary University of London , Sorbonne Universite , Assistance Publique-Hopitaux De Paris , The University of Sheffield
Inventor: Gilbert Bensimon , Peter Nigel Leigh , Timothy Tree , Cecilia Garlanda , Massimo Locati , Janine Kirby , Pamela Shaw , Andrea Malaspina
IPC: A61K38/20 , A61K31/428 , A61P25/28
CPC classification number: A61K38/2013 , A61K31/428 , A61P25/28
Abstract: The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1×106 to 3×106 international units (IU). Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1×106 to 3×106 IU human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject. The treatment permits to decrease plasma CCL2 concentration and to change the polarization of blood macrophages from an M1 inflammatory phenotype to an anti-inflammatory M2 phenotype involved in tissue repair.
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公开(公告)号:US12097301B2
公开(公告)日:2024-09-24
申请号:US16619256
申请日:2018-06-07
Applicant: The University of Sheffield
Inventor: Sheila Macneil , Christopher Reginald Chapple , Sabiniano Roman Regueros , Christopher James Hillary , Anthony James Bullock
CPC classification number: A61L27/18 , A61F2/0036 , A61L27/3604 , A61L27/3834 , A61L27/56 , A61F2240/001 , A61L2430/22 , D01D5/003 , D10B2331/10 , D10B2509/00
Abstract: The present invention relates to a scaffold for the treatment of stress urinary incontinence, wherein the scaffold comprises three layers of polyurethane: a first layer and a third layer in which the polyurethane fibres are randomly orientated and a second layer between said first and third layers in which the fibres are aligned longitudinally; methods of making such scaffolds and uses thereof.
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公开(公告)号:US20240208048A1
公开(公告)日:2024-06-27
申请号:US18391235
申请日:2023-12-20
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Chris SCRAGGS , Adrian HIRST
CPC classification number: B25J9/162 , B25J5/007 , B25J15/0019
Abstract: A mobile robot for interacting with a workpiece is disclosed as the mobile robot transports across the ground relative to the workpiece. The mobile robot includes a tracker for tracking the workpiece; an end effector for interacting with the workpiece based on feedback from the tracker; and a control system. The control system is configured such that when the mobile robot is transporting in a transporting direction across the ground relative to the workpiece such that the tracker is tracking a first region of the workpiece, the control system causes the mobile robot to adjust according to the feedback from the tracker and effect a position of the end effector when interacting the end effector with the second region of the workpiece.
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公开(公告)号:US20230313134A1
公开(公告)日:2023-10-05
申请号:US18182829
申请日:2023-03-13
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Carlos Marcelo Nicolas Rivolta , Sarah Louise Boddy
IPC: C12N5/0797 , C07K16/28 , C07K16/30 , C07K16/18 , G01N33/569 , G01N33/48 , G01N33/53
CPC classification number: C12N5/0623 , C07K16/2896 , C07K16/3084 , C07K16/18 , G01N33/56966 , G01N33/48 , G01N33/53 , C07K16/28 , G01N2333/70596 , G01N2333/7452 , G01N2333/71 , G01N2333/916 , G01N2333/705
Abstract: The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.
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