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    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS
    93.
    发明申请
    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS 有权
    微生物可植入式无线压力传感器，用于生物医学应用和压力测量和传感器植入方法

    公开(公告)号：US20100294041A1

    公开(公告)日：2010-11-25

    申请号：US12848837

    申请日：2010-08-02

    申请人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    发明人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    IPC分类号： G01L9/12

    CPC分类号： A61B3/16 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  G01L9/0072

    摘要： A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure.

    摘要翻译： 可变电容器，包括可变电容器和电感器的微加工可植入压力传感器，以及相关的压力测量和植入方法。 电感器可以具有固定或可变电感。 可变电容器和压力传感器包括设置在基板上并限定腔室的柔性构件。 电容元件从柔性元件间接延伸。 施加到柔性构件的外表面上的足够的流体压力导致柔性构件移动或变形，从而导致电容和/或电感改变。 可以检测谐振频率或阻抗的所得变化以确定压力，例如眼内压。

    Method of manufacturing a micromachined polymer beam structure
    94.
    发明授权
    Method of manufacturing a micromachined polymer beam structure 有权
    微加工聚合物梁结构的制造方法

    公开(公告)号：US07774930B2

    公开(公告)日：2010-08-17

    申请号：US11492836

    申请日：2006-07-26

    申请人： Yu-Chong Tai ,  Yuji Suzuki

    发明人： Yu-Chong Tai ,  Yuji Suzuki

    IPC分类号： B44C1/22 ,  H05K3/28

    CPC分类号： B81B3/0078 ,  B81B2201/0235 ,  B81B2203/033 ,  B81C1/0015 ,  B81C1/0019 ,  B81C1/00484 ,  Y10T29/49126 ,  Y10T29/49165

    摘要： An integrated composite beam structure. The structure has a substrate, which includes a surface and a thickness defined underlying the surface. The substrate is composed of a first material. A thickness of polymer based material includes a first portion, a length, and a second portion. The second is coupled to a portion of the substrate. The length is defined between the first portion and the second portion. The structure also has a spring constant (K) of less than a predetermined amount (e.g., 10 N/m, 1 N/m) characterizing the length of the polymer based beam structure. The first portion is capable of moving in a first direction characterized by the spring constant upon application of an externally applied force and is substantially fixed in a second direction, which is normal to the first direction. The second end is capable of returning to a predetermined state when the externally applied force has been removed. The second portion includes a selected geometric configuration to secure the second portion to the portion of the substrate.

    摘要翻译： 一体化复合梁结构。 该结构具有基底，其包括表面和在该表面下方限定的厚度。 基板由第一材料构成。 聚合物基材料的厚度包括第一部分，长度和第二部分。 第二个耦合到衬底的一部分。 长度限定在第一部分和第二部分之间。 该结构还具有小于基于聚合物的梁结构的长度的小于预定量（例如，10N / m，1N / m）的弹簧常数（K）。 第一部分能够在施加外部施加的力的情况下沿着特征为弹簧常数的第一方向移动，并且基本上固定在与第一方向垂直的第二方向上。 当外部施加的力被去除时，第二端能够返回到预定状态。 第二部分包括选定的几何构型，以将第二部分固定到基底的该部分。

    DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE
    95.
    发明申请
    DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE 有权
    药物输送泵和制造方法

    公开(公告)号：US20100004639A1

    公开(公告)日：2010-01-07

    申请号：US12463254

    申请日：2009-05-08

    申请人： Changlin Pang ,  Fukang Jiang ,  Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Yu-Chong Tai

    发明人： Changlin Pang ,  Fukang Jiang ,  Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Yu-Chong Tai

    IPC分类号： A61K9/22

    CPC分类号： A61F9/00781 ,  A61F9/0017 ,  A61M5/1408 ,  A61M5/142 ,  A61M5/14276 ,  A61M5/14593 ,  A61M5/16886 ,  A61M39/24 ,  A61M2005/14204 ,  A61M2005/14264 ,  A61M2205/0244 ,  A61M2210/0612 ,  B44C1/227 ,  Y10T156/1092 ,  Y10T156/1093 ,  Y10T307/625

    摘要： Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon.

    摘要翻译： 可植入电解泵的实施例包括电解室，药物室和渗透室，渗透室具有与药物室接触的第一部分和暴露于便于与周围流体接触的第二部分。 泵还包括用于从药物腔室导出液体的插管和电解室内的电解电极，用于在其中产生气体，电解和药物室接触，使得电解室内的气体电解迫使来自药物室的流体进入 插管，药物室和渗透室之间的接触，允许从周围流体进入渗透室的流体以抵消药物室的体积损失并防止其上的真空压力的累积。

    On-chip temperature controlled liquid chromatography methods and devices
    97.
    发明授权
    On-chip temperature controlled liquid chromatography methods and devices 失效
    片上温度控制液相色谱方法和装置

    公开(公告)号：US07530259B2

    公开(公告)日：2009-05-12

    申请号：US11059625

    申请日：2005-02-17

    申请人： Yu-Chong Tai ,  Jun Xie ,  Chi-yuan Shih ,  Qing He

    发明人： Yu-Chong Tai ,  Jun Xie ,  Chi-yuan Shih ,  Qing He

    IPC分类号： G01N1/00 ,  G01N30/00

    CPC分类号： G01N30/54 ,  G01N30/30 ,  G01N30/6095 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053 ,  G01N2035/00108

    摘要： An apparatus for liquid chromatography comprises a liquid chromatography separation column on a substrate, wherein the separation column is coupled to a heater on the substrate. A chip-based temperature controlled liquid chromatography device comprises a substrate, a thermal isolation zone, and a separation column thermally isolated from the substrate by the thermal isolation zone. An apparatus for chip-based liquid chromatography comprising a cooling device is provided. A temperature gradient liquid chromatography system comprises a chip-based temperature controlled liquid chromatography device, a fluidic coupling, and an electrical interface. Methods of making and methods of using of chip-based temperature gradient liquid chromatography devices are also provided.

    摘要翻译： 用于液相色谱的装置包括在基底上的液相色谱分离柱，其中分离柱与基底上的加热器相连。 基于芯片的温度控制液相色谱装置包括基底，热隔离区和通过热隔离区与基底热隔离的分离柱。 提供了一种包括冷却装置的基于芯片的液相色谱仪。 温度梯度液相色谱系统包括基于芯片的温度控制液相色谱装置，流体耦合和电接口。 还提供了制备方法和使用基于芯片的温度梯度液相色谱装置的方法。

    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS
    98.
    发明申请
    MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS 有权
    微生物可植入式无线压力传感器，用于生物医学应用和压力测量和传感器植入方法

    公开(公告)号：US20080058632A1

    公开(公告)日：2008-03-06

    申请号：US11847262

    申请日：2007-08-29

    申请人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    发明人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    IPC分类号： A61B3/00 ,  G01L9/12 ,  G01R27/26

    CPC分类号： A61B3/16 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  G01L9/0072

    摘要： A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure.

    摘要翻译： 可变电容器，包括可变电容器和电感器的微加工可植入压力传感器，以及相关的压力测量和植入方法。 电感器可以具有固定或可变电感。 可变电容器和压力传感器包括设置在基板上并限定腔室的柔性构件。 电容元件从柔性元件间接延伸。 施加到柔性构件的外表面上的足够的流体压力导致柔性构件移动或变形，从而导致电容和/或电感改变。 可以检测谐振频率或阻抗的所得变化以确定压力，例如眼内压。

    Integrated capacitive microfluidic sensors method and apparatus
    99.
    发明授权
    Integrated capacitive microfluidic sensors method and apparatus 有权
    集成电容微流体传感器的方法和装置

    公开(公告)号：US07254008B2

    公开(公告)日：2007-08-07

    申请号：US11089338

    申请日：2005-03-25

    申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    IPC分类号： H01G7/00

    CPC分类号： G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

    摘要： A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

    摘要翻译： 用于电容感测的微流体装置和方法。 该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。 另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和 所述第二电容器电极至少在所述腔区域内引起电场。 基于聚合物的膜包括聚合物。

    Implantable mechanical pressure sensor and method of manufacturing the same
    100.
    发明授权
    Implantable mechanical pressure sensor and method of manufacturing the same 有权
    可植入式机械压力传感器及其制造方法

    公开(公告)号：US07252006B2

    公开(公告)日：2007-08-07

    申请号：US11148124

    申请日：2005-06-07

    申请人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark Humayun

    发明人： Yu-Chong Tai ,  Ellis Meng ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark Humayun

    IPC分类号： G01L9/00

    CPC分类号： A61B3/16 ,  A61B2562/02 ,  A61B2562/028 ,  G01L7/045

    摘要： A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention includes a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the current invention requires zero power consumption and indicates the pressure variation by changes of the in situ in-plane motion of the sensor, which can be gauged externally by a direct and convenient optical observation. In one embodiment, the pressure sensor of the current invention has been shown to work as an IOP sensor for eye implantation where the intraocular in-plane motion of the sensor can be recorded from outside of the eye, such that the intraocular pressure in glaucoma patients can be constantly monitored.

    摘要翻译： 提供生物相容的，机械的，微加工的压力传感器以及制造这种压力传感器的方法。 本发明的压力传感器包括通过一层聚对二甲苯工艺制造的高纵横比弯曲管结构。 本发明的压力传感器需要零功率消耗，并且通过传感器的原位面内运动的变化来指示压力变化，其可以通过直接和方便的光学观察在外部测量。 在一个实施例中，本发明的压力传感器已经被证明可用作眼睛植入的IOP传感器，其中可以从眼睛外部记录传感器的眼内平面内运动，使得青光眼患者的眼内压 可以不断监控。