公开(公告)号：US08886313B2

公开(公告)日：2014-11-11

申请号：US12822487

申请日：2010-06-24

申请人： Krzysztof Z. Siejko ,  Shibaji Shome ,  Jiang Ding

发明人： Krzysztof Z. Siejko ,  Shibaji Shome ,  Jiang Ding

IPC分类号： A61N1/05 ,  A61N1/365 ,  A61N1/36 ,  A61N1/368 ,  A61N1/37

CPC分类号： A61N1/3704 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3686 ,  A61N1/371

摘要： Approaches to rank potential left ventricular (LV) pacing vectors are described. Early elimination tests are performed to determine the viability of LV cathode electrodes. Some LV cathodes are eliminated from further testing based on the early elimination tests. LV cathodes identified as viable cathodes are tested further. Viable LV cathode electrodes are tested for hemodynamic efficacy. Cardiac capture and phrenic nerve activation thresholds are then measured for potential LV pacing vectors comprising a viable LV cathode electrode and an anode electrode. The potential LV pacing vectors are ranked based on one or more of the hemodynamic efficacy of the LV cathodes, the cardiac capture thresholds, and the phrenic nerve activation thresholds.

摘要翻译： 描述了评估潜在的左心室（LV）起搏向量的方法。 执行早期消除测试以确定LV阴极的可行性。 基于早期消除测试，一些LV阴极被进一步测试消除。 确定为阴极的LV阴极被进一步测试。 测试可行的LV阴极电极的血液动力学效能。 然后测量包含可行的LV阴极电极和阳极电极的潜在LV起搏向量的心脏捕获和膈神经激活阈值。 潜在的LV起搏向量基于LV阴极的血液动力学功效，心脏捕获阈值和膈神经激活阈值中的一种或多种进行排名。

公开(公告)号：US08805503B2

公开(公告)日：2014-08-12

申请号：US12699457

申请日：2010-02-03

申请人： Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

发明人： Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362

CPC分类号： A61N1/36592 ,  A61B5/02405 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/368

摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.

摘要翻译： 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。

公开(公告)号：US08676314B2

公开(公告)日：2014-03-18

申请号：US12435915

申请日：2009-05-05

申请人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

发明人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

IPC分类号： A61N1/00

CPC分类号： A61N1/371 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method of operating a cardiac therapy system to deliver cardiac resynchronization therapy (CRT) pacing that includes pacing both ventricles or pacing only the left ventricle is described. Delivery of the CRT pacing to one or both ventricles is scheduled for a cardiac cycle. If an intrinsic depolarization of a ventricle is detected during a pacing delay of the ventricle, then the scheduled CRT pacing to the ventricle is inhibited for the cycle. The intrinsic interval of the ventricle, such as the intrinsic atrioventricular interval concluded by the intrinsic depolarization, is measured. During a subsequent cardiac cycle, the pacing delay of the ventricle is decreased to be less than or equal to the measured intrinsic interval. Capture of the ventricle is verified after pacing is delivered during the subsequent cardiac cycle.

摘要翻译： 描述了一种操作心脏治疗系统以递送心脏再同步治疗（CRT）起搏的方法，其包括仅对左心室起搏两个心室或起搏。 将CRT起搏送至一个或两个心室，安排进行心动周期。 如果在心室的起搏延迟期间检测到心室的内在去极化，则对该周期抑制预定的对心室的CRT起搏。 测量心室的固有间隔，例如内在去极化结束的内在房室间隔。 在随后的心动周期中，心室的起搏延迟降低到小于或等于测量的固有间期。 在随后的心动周期内进行起搏后验证心室的获取。

公开(公告)号：US08565880B2

公开(公告)日：2013-10-22

申请号：US13094416

申请日：2011-04-26

申请人： Yanting Dong ,  Allan C. Shuros ,  Jiang Ding ,  Scott A. Meyer ,  Shibaji Shome

发明人： Yanting Dong ,  Allan C. Shuros ,  Jiang Ding ,  Scott A. Meyer ,  Shibaji Shome

IPC分类号： A61N1/36

CPC分类号： A61N1/371 ,  A61B5/0031 ,  A61B5/04525 ,  A61B5/7264 ,  A61N1/3712 ,  A61N1/37247

摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.

摘要翻译： 本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征 所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

公开(公告)号：US20130190636A1

公开(公告)日：2013-07-25

申请号：US13552996

申请日：2012-07-19

申请人： Shibaji Shome ,  Pramodsingh Hirasingh Thakur ,  Yinghong Yu ,  Keith L. Herrmann ,  Aaron R. McCabe ,  Jiang Ding

发明人： Shibaji Shome ,  Pramodsingh Hirasingh Thakur ,  Yinghong Yu ,  Keith L. Herrmann ,  Aaron R. McCabe ,  Jiang Ding

IPC分类号： A61B5/0456 ,  A61B5/04

CPC分类号： A61B5/0456 ,  A61B5/04012 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3702 ,  A61N1/37247 ,  A61N1/3918

摘要： A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.

摘要翻译： 一种系统包括心脏信号感测和处理电路。 心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。 处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。 处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。

公开(公告)号：US08483825B2

公开(公告)日：2013-07-09

申请号：US12336064

申请日：2008-12-16

申请人： Yinghong Yu ,  Jiang Ding

发明人： Yinghong Yu ,  Jiang Ding

IPC分类号： A61N1/00

CPC分类号： A61N1/368 ,  A61B5/0452 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： At least one of a left intraventricular conduction defect, a right intraventricular conduction defect, or no intraventricular conduction defect can be detected using received intrinsic cardiac information from a subject, and a first atrioventricular (AV) delay can be calculated using a first relationship if the left intraventricular conduction defect or no intraventricular conduction defect is detected, or a second AV delay can be calculated using a second relationship if the right intraventricular conduction defect is detected.

摘要翻译： 可以使用来自受试者的接收的固有心脏信息来检测左室内传导缺陷，右心室内传导缺陷或无心室内传导缺陷中的至少一个，并且可以使用第一关系来计算第一房室（AV）延迟，如果 如果检测到右心室传导缺陷，则检测到左心室内传导缺陷或无心室传导缺陷，或者可以使用第二关系计算第二AV延迟。

公开(公告)号：US20130145876A1

公开(公告)日：2013-06-13

申请号：US13575624

申请日：2010-11-01

申请人： Yangzhi Chen ,  Zhen Chen ,  Jiang Ding

发明人： Yangzhi Chen ,  Zhen Chen ,  Jiang Ding

IPC分类号： F16H1/12

CPC分类号： F16H1/12 ,  B81B5/00 ,  B81B2201/037 ,  F16H1/24 ,  F16H37/065 ,  F16H55/0853 ,  Y10T74/1966 ,  Y10T74/19972

摘要： A space curve mesh driving pair and a polyhedral space curve mesh transmission are disclosed. Said space curve mesh driving pair consists of a driving wheel and a driven wheel. Axes of the driving wheel and the driven wheel are intersected at an angle of 0°˜180°, and power transmission is realized by continuous mesh between the driving tines and the driven tines; a number of driving tines are provided on said driving wheel, and a number of driven tines are provided on the driven wheel; the driving tines are uniformly arranged on an end face of a cylinder of the driving wheel, and the driven tines are uniformly arranged on the circumference of a cylindrical surface of the driven wheel. Said polyhedral space curve mesh transmission consists of an above-mentioned space curve mesh driving pair. Motion is input from an input end, and is passed through a number of pace curve mesh driving pairs to realize the speed change, then is output from one or more output ends. Wherein, the space curve mesh driving pair is the core of the transmission. The invention has the advantages of compact structure, small size, light weight, stable transmission and flexible operation, and can be widely used in micro-mechanism field.

摘要翻译： 公开了空间曲线网格驱动对和多面体空间曲线网格传输。 所述空间曲线网格驱动对由驱动轮和从动轮组成。 驱动轮和从动轮的轴线以0°〜180°的角度相交，通过驱动齿和从动齿之间的连续啮合实现动力传递; 在所述驱动轮上设置有多个行进齿，并且在所述从动轮上设置有多个从动齿; 驱动齿均匀地布置在驱动轮的气缸的端面上，并且从动齿均匀地布置在从动轮的圆柱形表面的圆周上。 所述多面体空间曲线网格传输由上述空间曲线网格驱动对组成。 运动是从输入端输入的，并通过多个速度曲线网格驱动对来实现速度变化，然后从一个或多个输出端输出。 其中，空间曲线网格驱动对是传输的核心。 本发明结构紧凑，体积小，重量轻，传动稳定，操作灵活，可广泛应用于微机械领域。

公开(公告)号：US08175703B2

公开(公告)日：2012-05-08

申请号：US11338935

申请日：2006-01-25

申请人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

发明人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/3684

摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

摘要翻译： 系统和方法涉及使用多个CRT优化过程来确定CRT参数。 每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。 可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。 可以基于返回的推荐参数的组合来确定CRT参数。 可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

公开(公告)号：US08121685B2

公开(公告)日：2012-02-21

申请号：US12622602

申请日：2009-11-20

申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

IPC分类号： A61N1/00

CPC分类号： A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

摘要翻译： 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

公开(公告)号：US08103345B2

公开(公告)日：2012-01-24

申请号：US12955218

申请日：2010-11-29

申请人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC分类号： A61N1/365

CPC分类号： E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。