公开(公告)号：US20070270444A1

公开(公告)日：2007-11-22

申请号：US11369220

申请日：2006-03-06

Applicant: David Bebbington ,  Hayley Binch ,  Ronald Knegtel ,  Julian Golec ,  Sanjay Patel ,  Jean-Damien Charrier ,  David Kay ,  Robert Davies ,  Pan Li ,  Marion Wannamaker ,  Cornelia Forster ,  Albert Pierce

Inventor： David Bebbington ,  Hayley Binch ,  Ronald Knegtel ,  Julian Golec ,  Sanjay Patel ,  Jean-Damien Charrier ,  David Kay ,  Robert Davies ,  Pan Li ,  Marion Wannamaker ,  Cornelia Forster ,  Albert Pierce

IPC: A61K31/519 ,  A61K31/505 ,  A61P35/00 ,  A61P7/12 ,  A61P9/00 ,  C07D401/00 ,  C07D471/00

CPC classification number: C07D401/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D487/04 ,  C07D491/04 ,  C07D491/10 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

Abstract translation: 本发明描述了式IV的新型吡唑化合物：其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R“X”和“R”独立地选自TR 3，或者与它们的插入原子一起形成稠合的，不饱和的或部分不饱和的， 具有1-3个选自氧，硫或氮的环杂原子的5-8元环; 和R 2，R 2，R 3和R 3如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。

公开(公告)号：US20070250469A1

公开(公告)日：2007-10-25

申请号：US11379354

申请日：2006-04-19

Applicant: Erland Unruh ,  David Kay

Inventor： Erland Unruh ,  David Kay

IPC: G06F17/30

CPC classification number: G06F17/30631 ,  Y10S707/99933 ,  Y10S707/99936 ,  Y10S707/99942

Abstract: A computer readable storage medium tangibly embodying machine-readable digital data arranged to facilitate expedited searching. The data includes a plurality of words residing in a table having rows and columns, each word residing in a different row and each letter of the word occupying a different column in that row. Each continuous run of same letters in a column forms an interval. The words are positioned relative to each other to maximize lengths of the intervals, and/or optimize efficiency of compression of the columns by run length encoding.

Abstract translation: 一种计算机可读存储介质，其有形地体现为便于快速搜索的机读数字数据。 数据包括位于具有行和列的表中的多个单词，每个单词驻留在不同行中，并且该单词的每个字母占据该行中的不同列。 列中相同字母的每个连续运行形成一个间隔。 这些单词相对于彼此定位以最大化间隔的长度，和/或通过行程长度编码来优化列的压缩效率。

公开(公告)号：US20070179133A1

公开(公告)日：2007-08-02

申请号：US11504528

申请日：2006-08-15

Applicant: David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard

Inventor： David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/53 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC classification number: C07D403/12

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

公开(公告)号：US20060173461A1

公开(公告)日：2006-08-03

申请号：US11340026

申请日：2006-01-26

Applicant: David Kay ,  Lee Strnad ,  Dustin Ducharrme

Inventor： David Kay ,  Lee Strnad ,  Dustin Ducharrme

IPC: A61B17/58

CPC classification number: A61B17/8625 ,  A61B17/861 ,  A61B17/8635

Abstract: The present invention relates to a cannulated orthopedic screw having a torque driving head with a spherical wall for multiaxial use, a rounded fluted insertion tip and a threaded portion including a cancellous thread contiguous with a non-threaded portion. The threaded portion has a major diameter defined by a spiraling cancellous type thread and a minor diameter. The screw includes a multilobe torque driving recess.

Abstract translation: 本发明涉及一种具有扭矩驱动头的插管式矫形螺钉，该扭矩驱动头具有用于多轴使用的球形壁，圆形槽纹插入尖端和包括与无螺纹部分相邻的松质线的螺纹部分。 螺纹部分具有由螺旋形松质线型和小直径限定的大直径。 螺杆包括多叶扭矩驱动凹部。

公开(公告)号：US20060051517A1

公开(公告)日：2006-03-09

申请号：US10849302

申请日：2004-09-03

Applicant: Daniel Haas ,  David Kay ,  Ravi Sharma

Inventor： Daniel Haas ,  David Kay ,  Ravi Sharma

IPC: B01J19/08

CPC classification number: H01L23/345 ,  H01L24/95 ,  H01L25/50 ,  H01L2224/83234 ,  H01L2224/95085 ,  H01L2224/95136 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/0101 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01019 ,  H01L2924/01021 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01049 ,  H01L2924/01052 ,  H01L2924/01057 ,  H01L2924/0106 ,  H01L2924/01074 ,  H01L2924/01082 ,  H01L2924/10329 ,  H01L2924/12041 ,  H01L2924/12044 ,  H01L2924/14 ,  H01L2924/15155 ,  H01L2924/15165 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/3025 ,  H01L2924/15153

Abstract: A support and a method for fluidic assembly are provided. The support has a surface having binding sites adapted to receive micro-components of a type that are applied to the surface using a fluid; and energy absorbing heat producers at selected binding site. Each energy absorbing heat producer is adapted to receive energy and to transduce a portion of the received energy to heat the fluid proximate to the selected binding sites; so that when the micro-components are applied using a fluid that increases viscosity when heated, the heat generated by the energy absorbing heat producers increases the viscosity of the fluid proximate to the selected binding sites to prevent the micro-components from attaching to the selected binding sites.

Abstract translation: 提供了一种用于流体组装的支撑件和方法。 支撑体具有表面，其具有适于接收使用流体施加到表面的类型的微组件的结合位点; 和能量吸收热选择结合位点的热生产者。 每个能量吸收制热器适于接收能量并转换一部分接收的能量以加热接近所选择的结合位点的流体; 使得当使用在加热时增加粘度的流体施加微组件时，由能量吸收热生产者产生的热增加了靠近所选结合位点的流体的粘度，以防止微组件附着到所选择的结合位点 结合位点。

公开(公告)号：US20050266172A1

公开(公告)日：2005-12-01

申请号：US10855719

申请日：2004-05-27

Applicant: David Kay ,  Mitchell Burberry ,  Andrea Rivers ,  Michael Boroson ,  Lee Tutt ,  Giana Phelan ,  Daniel Haas ,  Kelvin Nguyen ,  Bradley Phillips

Inventor： David Kay ,  Mitchell Burberry ,  Andrea Rivers ,  Michael Boroson ,  Lee Tutt ,  Giana Phelan ,  Daniel Haas ,  Kelvin Nguyen ,  Bradley Phillips

IPC: H01L51/00 ,  H01L51/30 ,  H01L51/56 ,  H05B6/00

CPC classification number: H01L51/0013 ,  C23C14/048 ,  H01L51/0052 ,  H01L51/0059 ,  H01L51/0062 ,  H01L51/0081 ,  H01L51/0084 ,  H01L51/0085 ,  H01L51/0089 ,  H01L51/56

Abstract: A method of transferring organic material from a donor element to a substrate includes providing a radiation source; and selecting the power of the radiation applied to the donor element by the radiation source to cause the transfer of organic material to the substrate wherein the time that one or more positions of the donor element receives radiation is greater than 1 millisecond.

Abstract translation: 将有机材料从供体元件转移到衬底的方法包括提供辐射源; 以及通过辐射源选择施加到施主元件的辐射的功率，以使有机材料转移到衬底，其中施主元件的一个或多个位置接收辐射的时间大于1毫秒。

公开(公告)号：US20050209255A1

公开(公告)日：2005-09-22

申请号：US11046664

申请日：2005-01-26

Applicant: Juan-Miguel Jimenez ,  Sanjay Patel ,  David Kay ,  Ronald Knegtel ,  Oliver Philps

Inventor： Juan-Miguel Jimenez ,  Sanjay Patel ,  David Kay ,  Ronald Knegtel ,  Oliver Philps

IPC: A61K31/519 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/12 ,  C07D487/14

CPC classification number: C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/12

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：US20050198023A1

公开(公告)日：2005-09-08

申请号：US11056733

申请日：2005-02-11

Applicant: Christina James ,  Mark Brighton ,  Lisa Nathan ,  Ethan Bradford ,  David Kay

Inventor： Christina James ,  Mark Brighton ,  Lisa Nathan ,  Ethan Bradford ,  David Kay

IPC: G06F17/22 ,  G06F17/27 ,  G06F7/00

CPC classification number: G06F3/0236 ,  G06F17/276 ,  Y10S707/99931 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935 ,  Y10S707/99936

Abstract: The invention provides a process for selecting and ordering one or more sets of linguistic objects. The invention orders a current list of items for selection that comprises a first list of one or more items of a first language and a second list of one or more items of a second language, the current list of items being displayed in an order based on the first language having a priority over the second language. In response to a user selection of one item from the second list, the invention changes a priority for ordering a subsequent list of items to order the subsequent list of items based on the second language having a priority over the first language.

Abstract translation: 本发明提供了一种用于选择和排序一组或多组语言对象的过程。 本发明命令包括第一语言的一个或多个项目的第一列表和第二语言的一个或多个项目的第二列表的当前列表，该当前项目列表以基于 第一语言优先于第二语言。 响应于用户从第二列表中选择一个项目，本发明改变了排序随后的项目列表的优先级，以便基于具有优先于第一语言的优先级的第二语言来订购随后的项目列表。

公开(公告)号：US20050017954A1

公开(公告)日：2005-01-27

申请号：US10866634

申请日：2004-06-10

Applicant: David Kay ,  Ethan Bradford ,  Pim van Meurs ,  Peter Peddie

Inventor： David Kay ,  Ethan Bradford ,  Pim van Meurs ,  Peter Peddie

IPC: G06F3/023 ,  G06F17/27 ,  G09G5/00

CPC classification number: G06F3/0233 ,  G06F3/0235 ,  G06F3/0237 ,  G06F17/276

Abstract: The invention concerns user entry of information into a system with an input device. A scheme is provided in which an entire word that a user wants to enter is predicted after the user enters a specific symbol, such as a space character. If the user presses an ambiguous key thereafter, rather than accept the prediction, the selection list is reordered. For example, a user enters the phrase “Lets run to school. Better yet, lets drive to “.””” After the user presses the space, after first entering the second occurrence of the word “to,” the system predicts that the user is going to enter the word “school” based on the context in which the user has entered that word in the past. Should the user enter an ambiguous key after the space, then a word list which contains the word “school” is reordered and other options are made available to the user. The invention can also make predictions on context, such as the person to whom the message is sent, the person writing the message, the day of the week, the time of the week, etc. Other embodiments of the invention contemplate anticipation of user actions, as well as words, such as a user action in connection with menu items, or a user action in connection with form filling.

Abstract translation: 本发明涉及用户通过输入设备将信息输入系统。 提供一种方案，其中在用户输入诸如空格字符的特定符号之后预测用户想要输入的整个单词。 如果用户之后按下模糊键，而不是接受预测，则选择列表被重新排序。 例如，用户输入短语“让我们跑到学校，更好，让我们开车去”。“”“用户按住空格后，首先进入第二次出现的单词”to“后，系统预测 用户将根据用户在过去输入该单词的上下文输入单词“school”，如果用户在空格之后输入模糊键，则重新排序包含单词“school”的单词列表 本发明还可以对上下文进行预测，诸如发送消息的人，撰写消息的人，星期几，星期几等。 本发明的其他实施例考虑了对用户动作的预期，以及诸如与菜单项相关的用户动作或与表单填充有关的用户动作的单词。

公开(公告)号：US06846928B2

公开(公告)日：2005-01-25

申请号：US10389707

申请日：2003-03-14

Applicant: David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian M. C. Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard ,  Albert C. Pierce

Inventor： David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian M. C. Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard ,  Albert C. Pierce

IPC: A61P35/00 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D239/28

CPC classification number: C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。