Protein and monoclonal antibody specific thereto
    92.
    发明授权
    Protein and monoclonal antibody specific thereto 失效
    与其特异的蛋白质和单克隆抗体

    公开(公告)号:US06191255B1

    公开(公告)日:2001-02-20

    申请号:US09000041

    申请日:1998-02-20

    IPC分类号: A61K3843

    摘要: A novel protein which is useful as a diagnostic means for studies relating to the diagnosis and treatment of cancer (detection of cancer cells, estimation of the malignity, etc.) and for other medicinal and physiological purposes; a gene encoding the same; and an antibody, in particular, a monoclonal antibody specific to the protein. MT-MMP-3, which is a pro MMP-2 activator having the ability to activate pro MMP-2 which is under expression specifically on the surface layer of a human cancer cell and falling within the category of MMP but being different from MT-MMP-1; a DNA containing the base sequence encoding the same; host cells transformed by the DNA; a process for producing a matrix metalloproteinase protein by using the host cells; a monoclonal antibody binding specifically to the matrix metalloproteinase protein; and use of the protein and antibody.

    摘要翻译: 一种新的蛋白质,其可用于诊断和治疗癌症的诊断手段(癌细胞的检测,恶性的估计等)和其他药物和生理目的; 编码该基因的基因; 和抗体,特别是针对蛋白质的单克隆抗体。 MT-MMP-3,其是具有活化pro MMP-2的能力的促MMP-2激活剂,其特异性在人癌细胞的表面上表达并且属于MMP类别,但不同于MT- MMP-1; 含有编码其的碱基序列的DNA; 由DNA转化的宿主细胞; 通过使用宿主细胞产生基质金属蛋白酶蛋白质的方法; 与基质金属蛋白酶蛋白特异性结合的单克隆抗体; 并使用蛋白质和抗体。

    Metalloproteinase and encoding DNA therefor
    93.
    发明授权
    Metalloproteinase and encoding DNA therefor 失效
    金属蛋白酶和编码DNA

    公开(公告)号:US06184022B2

    公开(公告)日:2001-02-06

    申请号:US08448489

    申请日:1995-06-07

    IPC分类号: C12N964

    CPC分类号: C12N9/6491

    摘要: A novel metalloproteinase, DNA encoding therefor, a plasmid carrying said DNA sequence and a host cell harbouring said plasmid, and monoclonal antibodies peculiarly recognizing said protein. Useful in applications pertaining to diagnosis of the presence of tumour cells, the degree of cancer malignancy, and other medical and physiological fields.

    摘要翻译: 一种新型金属蛋白酶,其编码的DNA,携带所述DNA序列的质粒和携带所述质粒的宿主细胞,以及特异性识别所述蛋白质的单克隆抗体。在诊断肿瘤细胞存在的程度,癌症恶性程度和 其他医疗和生理领域。

    Semiconductor integrated circuit with multiple write operation modes
    99.
    发明授权
    Semiconductor integrated circuit with multiple write operation modes 失效
    具有多种写操作模式的半导体集成电路

    公开(公告)号:US6091640A

    公开(公告)日:2000-07-18

    申请号:US941676

    申请日:1997-09-30

    摘要: A control of a flash memory includes control for supplying a pulse-shaped voltage to each of non-volatile memory cells until a threshold voltage of the non-volatile memory cell having a first threshold voltage is changed to a second threshold voltage. The control involves a first write mode (coarse write) in which the amount of change in threshold voltage of each non-volatile memory cell, which is varied each time the pulse-shaped voltage is applied, is relatively rendered high, and a second write mode (high-accuracy write) in which the amount of change in threshold voltage thereof is relatively rendered low. As compared with the high-accuracy mode, the number of pulses required to change the threshold voltage of each memory cell is smaller than that in the coarse write mode. Therefore, the number of verify operations at the time that the coarse write mode is used, is small and hence the entire write operation can be speeded up.

    摘要翻译: 闪速存储器的控制包括用于向每个非易失性存储单元提供脉冲状电压的控制,直到具有第一阈值电压的非易失性存储单元的阈值电压变为第二阈值电压为止。 控制涉及第一写入模式(粗写),其中每当施加脉冲形状电压时变化的每个非易失性存储单元的阈值电压的变化量相对变高,并且第二写入 模式(高精度写入),其中阈值电压的变化量相对低。 与高精度模式相比,改变每个存储单元的阈值电压所需的脉冲数小于粗写模式时的脉冲数。 因此,使用粗写入模式时的验证操作数量很少,因此可以加快整个写入操作。