公开(公告)号：US20130190837A1

公开(公告)日：2013-07-25

申请号：US13792805

申请日：2013-03-11

申请人： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

发明人： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

IPC分类号： A61N1/36

CPC分类号： A61N1/36117 ,  A61N1/08 ,  A61N1/36171

摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供了一种装置。 在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并适于接收和处理 神经交通信号从引导到指示神经交通的信号。 该装置包括连接到脉冲发生器和信号处理模块的控制器。 控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。 本文提供了其他方面。

公开(公告)号：US08483834B2

公开(公告)日：2013-07-09

申请号：US13285457

申请日：2011-10-31

申请人： Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu ,  Paul A. Haefner ,  Kristofer J. James

发明人： Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu ,  Paul A. Haefner ,  Kristofer J. James

IPC分类号： A61N1/08

CPC分类号： A61N1/36135 ,  A61B5/0215 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601

摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.

公开(公告)号：US08478397B2

公开(公告)日：2013-07-02

申请号：US12686704

申请日：2010-01-13

申请人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

发明人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/3621 ,  A61N1/3627

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面提供可植入装置。 在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。

公开(公告)号：US08460189B2

公开(公告)日：2013-06-11

申请号：US12209265

申请日：2008-09-12

申请人： Imad Libbus ,  Yatheendhar D. Manicka ,  Rich Fogoros

发明人： Imad Libbus ,  Yatheendhar D. Manicka ,  Rich Fogoros

IPC分类号： A61B5/00

CPC分类号： A61B5/0006 ,  A61B5/04028 ,  A61B5/0404 ,  A61B5/04085 ,  A61B5/0537 ,  A61B5/061 ,  A61B5/11 ,  A61B5/4869 ,  A61B5/6823 ,  A61B5/6832 ,  A61B5/6833 ,  A61B5/684 ,  A61B5/721 ,  A61B2560/0412 ,  A61B2562/0219 ,  G01C9/06

摘要： An adherent device comprises an adhesive patch with at least two electrodes and an accelerometer. The accelerometer can be used to determine an orientation of the at least two measurement electrodes on a patient. By determining the orientation of the electrodes of the patch on the patient, physiologic measurements with the at least two electrodes can be adjusted and/or corrected in response to the orientation of the patch on the patient. The adherent patch and/or electrodes can be replaced with a second adherent patch and/or electrodes, and the orientation of the second adherent patch and/or electrodes can be determined with the accelerometer or a second accelerometer. The determined orientation of the second patch and/or electrodes on the patient can be used to correct measurements made with the second adherent patch and/or electrodes.

摘要翻译： 粘附装置包括具有至少两个电极和加速度计的粘合贴片。 加速度计可以用于确定患者身上的至少两个测量电极的取向。 通过确定患者上的贴片的电极的取向，可以响应于患者上的贴片的取向来调节和/或校正至少两个电极的生理学测量。 粘附贴片和/或电极可以用第二粘附贴片和/或电极代替，并且可以用加速度计或第二加速度计确定第二粘附片和/或电极的取向。 第二贴片和/或患者上的电极的确定的取向可用于校正用第二粘附片和/或电极进行的测量。

公开(公告)号：US08457746B2

公开(公告)日：2013-06-04

申请号：US13198477

申请日：2011-08-04

申请人： Imad Libbus

发明人： Imad Libbus

IPC分类号： A61N1/18

CPC分类号： A61N1/36139 ,  A61B5/0215 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/4035 ,  A61B5/4047 ,  A61N1/3611 ,  A61N1/36117

摘要： An aspect relates to a system for providing baroreflex stimulation. An embodiment of the system comprises a cardiac activity monitor to sense cardiac activity and provide a signal indicative of the cardiac activity, and a baroreflex stimulator. The stimulator includes a pulse generator and a modulator. The pulse generator provides a baroreflex stimulation signal adapted to provide a baroreflex therapy. The modulator receives the signal indicative of the cardiac activity and modulates the baroreflex stimulation signal based on the signal indicative of the cardiac activity to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.

摘要翻译： 一个方面涉及一种用于提供压力反射刺激的系统。 系统的一个实施例包括用于感测心脏活动并提供指示心脏活动的信号的心脏活动监测器和压力反射刺激器。 刺激器包括脉冲发生器和调制器。 脉冲发生器提供适于提供压力反射疗法的压力反射刺激信号。 调制器接收指示心脏活动的信号，并且基于指示心脏活动的信号调节压力反射刺激信号，以将压力反射治疗从第一压力反射治疗改变为第二压力反射治疗。

公开(公告)号：US08452398B2

公开(公告)日：2013-05-28

申请号：US12469012

申请日：2009-05-20

申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

IPC分类号： A61N1/365

CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

公开(公告)号：US20130123873A1

公开(公告)日：2013-05-16

申请号：US13731691

申请日：2012-12-31

申请人： Imad Libbus ,  Krzysztof Z. Siejko ,  Marina V. Brockway ,  Robert J. Sweeney

发明人： Imad Libbus ,  Krzysztof Z. Siejko ,  Marina V. Brockway ,  Robert J. Sweeney

IPC分类号： A61N1/365

CPC分类号： A61B5/0205 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/0402 ,  A61B5/0488 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/36139 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/36592 ,  A61N1/372 ,  A61N1/37288

摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

公开(公告)号：US20130053924A1

公开(公告)日：2013-02-28

申请号：US13660193

申请日：2012-10-25

申请人： Imad Libbus ,  Stefan Nikles

发明人： Imad Libbus ,  Stefan Nikles

IPC分类号： A61N1/37

CPC分类号： A61N1/0519 ,  A61B5/4035 ,  A61N1/0517 ,  A61N1/36007 ,  A61N1/3601 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/36185

摘要： Various system embodiments comprise a medical device, comprising a flexible tether, a neural stimulation circuit, and a controller. The flexible tether is adapted to be fed into a patient's throat. The flexible tether includes a plurality of electrodes. The neural stimulation circuit is adapted to deliver neural stimulation. The controller is adapted to control the neural stimulation circuit to provide a neural stimulation therapy using at least one electrode from the plurality of electrodes, and to implement a neural stimulation test routine. The neural stimulation test routine is adapted to assess neural stimulation efficacy for electrode subsets of the plurality of electrodes to identify a desired electrode subset for use in delivering the neural stimulation therapy to elicit a desired response.

摘要翻译： 各种系统实施例包括医疗装置，包括柔性系绳，神经刺激电路和控制器。 灵活的系绳适于喂入患者的喉咙。 柔性系链包括多个电极。 神经刺激电路适用于输送神经刺激。 控制器适于控制神经刺激电路，以使用来自多个电极的至少一个电极提供神经刺激治疗，并实施神经刺激测试程序。 神经刺激测试程序适于评估多个电极的电极子集的神经刺激功效，以识别用于递送神经刺激疗法以引出期望的反应的期望的电极子集。

公开(公告)号：US08301239B2

公开(公告)日：2012-10-30

申请号：US11624300

申请日：2007-01-18

申请人： Imad Libbus ,  Stefan Nikles

发明人： Imad Libbus ,  Stefan Nikles

IPC分类号： A61N1/36

CPC分类号： A61N1/0519 ,  A61B5/4035 ,  A61N1/0517 ,  A61N1/36007 ,  A61N1/3601 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/36185

摘要： Various system embodiments comprise a medical device, comprising a flexible tether, a neural stimulation circuit, and a controller. The flexible tether is adapted to be fed into a patient's throat. The flexible tether includes a plurality of electrodes. The neural stimulation circuit is adapted to deliver neural stimulation. The controller is adapted to control the neural stimulation circuit to provide a neural stimulation therapy using at least one electrode from the plurality of electrodes, and to implement a neural stimulation test routine. The neural stimulation test routine is adapted to assess neural stimulation efficacy for electrode subsets of the plurality of electrodes to identify a desired electrode subset for use in delivering the neural stimulation therapy to elicit a desired response.

摘要翻译： 各种系统实施例包括医疗装置，包括柔性系绳，神经刺激电路和控制器。 灵活的系绳适于喂入患者的喉咙。 柔性系链包括多个电极。 神经刺激电路适用于输送神经刺激。 控制器适于控制神经刺激电路，以使用来自多个电极的至少一个电极提供神经刺激治疗，并实施神经刺激测试程序。 神经刺激测试程序适于评估多个电极的电极子集的神经刺激功效，以识别用于递送神经刺激疗法以引出期望的响应的期望的电极子集。

公开(公告)号：US20120265273A1

公开(公告)日：2012-10-18

申请号：US13532469

申请日：2012-06-25

申请人： Imad Libbus ,  Avram Scheiner

发明人： Imad Libbus ,  Avram Scheiner

IPC分类号： A61N1/36

CPC分类号： A61N1/36057 ,  A61B5/021 ,  A61B5/024 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/37217 ,  A61N1/37282 ,  A61N1/37288

摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.

摘要翻译： 一个实施方案涉及用于递送单向传入神经刺激治疗的方法。 传递测试神经刺激，并监测对测试神经刺激的生理反应。 如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。 如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。 使用至少一个治疗参数递送单向传入神经刺激。